Protein Information

Name brain 4
Synonyms BRAIN 4; BRAIN4; BRN4; Brain specific homeobox; Brain specific homeobox/POU domain protein 4; Brn 4; DFN 3; DFN3…

Compound Information

Name 4-aminopyridine
CAS 4-pyridinamine

Reference List

PubMed Abstract RScore(About this table)
15530659 Vizi S, Bagosi A, Krisztin-Peva B, Gulya K, Mihaly A: Repeated 4-aminopyridine seizures reduce parvalbumin content in the medial mammillary nucleus of the rat brain. Brain Res Mol Brain Res. 2004 Nov 24;131(1-2):110-8.

In the present study, we examined whether repeated 4-aminopyridine (4-AP)-induced seizures modify the regional parvalbumin contents in the rat brain. 4-Aminopyridine was injected intraperitoneally in adult rats, controls received the solvent.
81(1,1,1,1) Details
12200216 Smyth MD, Barbaro NM, Baraban SC: Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia. Epilepsy Res. 2002 Aug;50(3):251-64.


Here we have used rats exposed to methylazoxymethanol acetate (MAM) in utero, an animal model featuring nodular heterotopia, to investigate the effects of AEDs in the dysplastic brain. 4-aminopyridine (100 microM), a K (+) channel blocker, was used to induce interictal epileptiform bursting in acute hippocampal slices from MAM-exposed and age-matched vehicle-injected control animals.
1(0,0,0,1) Details