| Name | beta adrenoceptors (protein family or complex) |
|---|---|
| Synonyms | Beta adrenoceptor; Beta adrenoceptor; Beta adrenergic receptor; Beta adrenergic receptors; Beta adrenoceptor; Beta adrenoceptors; Beta adrenoceptors |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11243423 | Murray F, Bell D, Kelso EJ, Millar BC, McDermott BJ: Positive and negative contractile effects of somatostatin-14 on rat ventricular cardiomyocytes. J Cardiovasc Pharmacol. 2001 Mar;37(3):324-32. Cells were stimulated at 0.5 Hz with CaCl2 (2 mM) under basal conditions and in the presence of the beta-adrenoceptor agonist, isoprenaline (1 nM), or the selective inhibitor of the transient outward current (Ito), 4-aminopyridine (500 microM). |
81(1,1,1,1) | Details |
| 17976578 | Wang SP, Zang WJ, Kong SS, Yu XJ, Sun L, Zhao XF, Wang SX, Zheng XH: Vasorelaxant effect of isopropyl 3-(3, 4-dihydroxyphenyl)- a novel metabolite from Salvia miltiorrhiza, on isolated rat mesenteric artery. Eur J Pharmacol. 2008 Jan 28;579(1-3):283-8. Epub 2007 Oct 13. Meanwhile, the vasorelaxant effect of IDHP was unaffected by pre-treatment with ATP-sensitive K (+) channel inhibitor glibenclamide, delayed rectifier K (+) channel inhibitor 4-aminopyridine, inwardly rectifying K (+) channel inhibitor barium and beta-adrenoceptor antagonist |
31(0,1,1,1) | Details |
| 19926936 | Martinez AC, Pagan RM, Prieto D, Recio P, Garcia-Sacristan A, Hernandez M, Benedito S: Modulation of noradrenergic neurotransmission in isolated rat radial artery. J Pharmacol Sci. 2009 Nov;111(3):299-311. Tetraethylammonium (TEA) or 4-aminopyridine, the Ca2+-activated (K (Ca)) or voltage-dependent K+ (K (V)) channel blockers, respectively, enhanced the neurogenic contractions observed. The beta-adrenoceptor antagonist diminished EFS-elicited contractions, while sensitivity to NA was enhanced by |
4(0,0,0,4) | Details |
| 10899051 | Mitarai S, Reed TD, Yatani A: Changes in ionic currents and beta-adrenergic receptor signaling in hypertrophied myocytes overexpressing G alpha (q). Am J Physiol Heart Circ Physiol. 2000 Jul;279(1):H139-48. Kinetics or sensitivity of I (to) to 4-aminopyridine was unchanged, but 4-aminopyridine prolonged the action potential more in G alpha (q) myocytes. |
3(0,0,0,3) | Details |
| 17435380 | Matsushita M, Tanaka Y, Koike K: Studies on the mechanisms underlying beta-adrenoceptor-mediated relaxation of rat abdominal aorta. J Smooth Muscle Res. 2006 Dec;42(6):217-25. Isoprenaline-induced relaxation in the presence of SQ 22,536 was significantly diminished by iberiotoxin (IbTx, 0.1 microM), but was not affected by 4-aminopyridine (4-AP, 3 mM). |
2(0,0,0,2) | Details |
| 14585815 | Mhaouty-Kodja S, Houdeau E, Legrand C: Regulation of myometrial phospholipase C system and uterine contraction by beta-adrenergic receptors in midpregnant rat. Biol Reprod. 2004 Mar;70(3):570-6. Epub 2003 Oct 29. In contrast, two global (K+) channel inhibitors, tetraethylammonium (TEA) and 4-aminopyridine (4-AP), prevented attenuation of InsP production by isoproterenol. |
2(0,0,0,2) | Details |
| 12798424 | Workman AJ, Kane KA, Russell JA, Norrie J, Rankin AC: Chronic beta-adrenoceptor blockade and human atrial cell electrophysiology: evidence of pharmacological remodelling. Cardiovasc Res. 2003 Jun 1;58(3):518-25. The I (TO) blocker 4-aminopyridine largely mimicked the changes in phase 1 and ERP associated with chronic beta-blockade, in cells from non-beta-blocked patients. |
2(0,0,0,2) | Details |
| 12595962 | Horinouchi T, Tanaka Y, Koike K: Evidence for the primary role for 4-aminopyridine-sensitive K (v) channels in beta (3)-adrenoceptor-mediated, cyclic AMP-independent relaxations of guinea-pig gastrointestinal smooth muscles. Naunyn Schmiedebergs Arch Pharmacol. 2003 Feb;367(2):193-203. Epub 2003 Jan 14. Gastrointestinal smooth muscles exhibit relaxation in response to the stimulation of beta-adrenoceptors with catecholamines. |
2(0,0,0,2) | Details |
| 12466248 | Wang SJ, Coutinho V, Sihra TS: Presynaptic cross-talk of beta-adrenoreceptor and 5-hydroxytryptamine receptor signalling in the modulation of release from cerebrocortical nerve terminals. Br J Pharmacol. 2002 Dec;137(8):1371-9. The presynaptic interactions between facilitatory beta-adrenoreceptors and inhibitory receptors modulating release from cerebrocortical nerve terminals were examined. 2. 4-aminopyridine (4-AP, 1 mM)-evoked release was facilitated by the membrane permeant cyclic-3',5'- (cAMP) analogue, 8-bromo-cAMP (8-Br-cAMP), used to directly activate cAMP-dependent protein kinase (PKA). 3. The inhibitory crosstalk of 5-HT (1A) receptors to beta-adrenoceptor-mediated facilitation of release was abolished in the presence of NAN-190. 7. |
1(0,0,0,1) | Details |
| 12491798 | Horinouchi T, Tanaka Y, Koike K: [Beta 3-adrenoceptor-mediated relaxation of guinea-pig gastric funds smooth muscle: cAMP-independent characteristics and a primary role of 4-aminopyridine-sensitive voltage-dependent K+ (Kv) channels]. Nippon Yakurigaku Zasshi. 2002 Nov;120(1):109P-111P. beta-Adrenoceptor subtypes which mediate relaxation of guinea-pig gastrointestinal smooth muscles in response to catecholamines ((-)-isoprenaline, (-)- and (-)- and beta 3-adrenoceptor agonists (BRL37344 and (+/-)-CGP12177A) are predominantly beta 3-adrenoceptors. |
1(0,0,0,1) | Details |
| 12297727 | Shi H, Wang H, Han H, Xu D, Yang B, Nattel S, Wang Z: Ultrarapid delayed rectifier K (+) current in H9c2 rat ventricular cell line: biophysical property and molecular identity. Cell Physiol Biochem. 2002;12(4):215-26. The H9c2 I (Kur) can be completely blocked by tetraethylammonium and 4-aminopyridine. H9c2 I (Kur) was increased by beta-adrenoceptor-PKA and decreased by alpha (1)-adrenoceptor-PKC activation by isoproterenol and respectively. |
1(0,0,0,1) | Details |
| 14727522 | Horinouchi T, Tanaka Y, Koike K: [beta-adrenoceptor subtypes involved in relaxations of guinea-pig gastrointestinal smooth muscles: distribution and signaling pathway of beta 3-adrenoceptors]. Nippon Yakurigaku Zasshi. 2003 Nov;122 Suppl:54P-56P. Furthermore, in the presence of SQ-22,536 (100 microM), the stimulation of beta 3-adrenoceptors elicited relaxations without an elevation of cAMP, indicating the involvement of cAMP-independent mechanism (s). beta 3-Adrenoceptor-mediated, cAMP-independent relaxations were significantly diminished by a Kv channel blocker, 4-aminopyridine (3 mM). |
1(0,0,0,1) | Details |
| 15755482 | del Carmen Godino M, Torres M, Sanchez-Prieto J: The modulation of Ca2+ and K+ channels but not changes in cAMP signaling contribute to the inhibition of release by cannabinoid receptors in cerebrocortical nerve terminals. Neuropharmacology. 2005 Mar;48(4):547-57. Epub 2005 Jan 25. Furthermore, WIN55,212-2 reduced 4-aminopyridine (4AP) evoked release to a larger extent by modulating the behavior of both Ca2+ and K (+)-channels. Forskolin and the beta-adrenergic receptor increase intrasynaptosomal cAMP and promote a PKA-dependent tetrodotoxin (TTX)-sensitive increase in the spontaneous release of |
1(0,0,0,1) | Details |
| 16247764 | Wang SJ: An investigation into the effect of the type IV phosphodiesterase inhibitor rolipram in the modulation of release from rat prefrontocortical nerve terminals. Synapse. 2006 Jan;59(1):41-50. In prefrontocortical nerve terminals, rolipram potentiated the Ca (2+)-dependent release of evoked by 4-aminopyridine (4AP) in a concentration-dependent manner. This potentiation of release was occluded by the activation of PKA by Sp-cAMP or beta-adrenergic receptor agonist and prevented by the inhibition of PKA by Rp-cAMP or KT5720, indicating a PKA-mediated mechanism. |
1(0,0,0,1) | Details |
| 16736155 | Bieger D, Parai K, Ford CA, Tabrizchi R: beta-adrenoceptor mediated responses in rat pulmonary artery: putative role of TASK-1 related K channels. Naunyn Schmiedebergs Arch Pharmacol. 2006 Jun;373(3):186-96. Epub 2006 Apr 25. While Rp-8-Br-cAMP (30.0 microM), tetraethylammonium (0.3 & 1.0 mM), 4-aminopyridine (100 microM), (10.0 microM), charybdotoxin (0.1 microM), ouabain (100 microM), and barium (100 microM), incompletely blocked relaxation to isoprenaline, cyclopiazonic acid (1.0 microM), apamin (3.0 microM) and zinc (300 microM) were without effect. |
1(0,0,0,1) | Details |
| 12359274 | Berg T: Analysis of the pressor response to the K+ channel inhibitor 4-aminopyridine. Eur J Pharmacol. 2002 Oct 11;452(3):325-37. These results are compatible with that the immediate tension response resulted from closure of vascular smooth muscle K (+) channels, and that closure of presynaptic K (+) channels in peripheral sympathetic nerves subsequently activated release, beta-adrenoceptors and tachycardia, while counter-acted a concomitant alpha-adrenergic vasoconstriction. |
1(0,0,0,1) | Details |
| 12021574 | Yeh JL, Wu JR, Chiu CC, Chen YW, Lo YC, Lin YT, Cheng CJ, Chen IJ: Vanillylamide-based propanolamine derivative displays alpha/beta-adrenoceptor blocking and vasodilating properties. J Cardiovasc Pharmacol. 2002 Jun;39(6):803-13. In conclusion, KMUP 880602 is an alpha/beta-adrenoceptor blocker, with selective beta1-adrenoceptor blocking and vascular smooth muscle relaxation activities. In isolated rat thoracic aorta, the vasorelaxant effects of KMUP 880602 on -induced contractions were attenuated by pretreatment with tetraethylammonium (10-3 M) and charybdotoxin (10-7 M) but not by glibenclamide, 4-aminopyridine, and apamin. |
1(0,0,0,1) | Details |
| 15973968 | Chai Q, Liu Z, Chen L: Effects of streptozotocin-induced diabetes on Kv channels in rat small coronary smooth muscle cells. Chin J Physiol. 2005 Mar 31;48(1):57-63. STZ-induced diabetes appeared to [corrected] reduce the vasodilation induced by beta-adrenoceptor agonist, isoproterenol (10 (-9)-10 (-5) mol/l), and adenylyl cyclase activator forskolin (10 (-9)-10 (-5) mol/l) respectively (isoproterenol: 44.2 +/- 6.7% vs. 82.5 +/- 4.8%, and forskolin: 54.4 +/- 4.5% vs. 94.3 +/- 2.4%). 4-AP, a Kv channel blocker of VSMC, further decreased dilation to isoproterenol (44.2 +/- 6.7% vs. 10.2 +/- 3.5%) and forskolin (54.4 +/- 4.5% vs. 13.8 +/- 11.0%) significantly. |
1(0,0,0,1) | Details |
| 12960683 | Quignard JF, Harley EA, Duhault J, Vanhoutte PM, Feletou M: K+ channels in cultured bovine retinal pericytes: effects of beta-adrenergic stimulation. J Cardiovasc Pharmacol. 2003 Sep;42(3):379-88. Physiologic stimuli such as an increase in extracellular concentration or beta-adrenergic receptor stimulation enhance the activity of Kir and BKCa, respectively, suggesting a potential role for these channels in the control of retinal blood flow. Their activation and inactivation properties, as well as their respective sensitivity to 4-aminopyridine and iberiotoxin, were indicative of voltage-sensitive and large-conductance -activated K+ channels (BKCa). |
1(0,0,0,1) | Details |
| 16112684 | Seto SW, Ho YY, Hui HN, Au AL, Kwan YW: Contribution of glibenclamide-sensitive, ATP-dependent K+ channel activation to acetophenone analogues-mediated in vitro pulmonary artery relaxation of rat. Life Sci. 2006 Jan 2;78(6):631-9. Epub 2005 Aug 22. Neither cis-N-(2-phenylcyclopentyl) azacyclotridec-1-en-2-amine (MDL 12330A, 10 microM), iberiotoxin (300 nM), 4-aminopyridine (3 mM), (+/-)- (1 microM, a non-selective beta-adrenoceptor blocker) nor 1H-[1,2,4] oxadiazolo [4,3-a] quinoxalin-1-one (ODQ) (3 microM, a guanylate cyclase inhibitor) altered endothelium-independent relaxation. |
0(0,0,0,0) | Details |
| 17960514 | Oh KS, Ryu SY, Kim YS, Lee BH: Large conductance Ca2+-activated K+ (BKCa) channels are involved in the vascular relaxations elicited by isolated from Rheum undulatum rhizome. Planta Med. 2007 Nov;73(14):1441-6. Epub 2007 Oct 24. The -induced relaxation was also blocked by raising the extracellular K (+) (45 mM), 4-aminopyridine (voltage-sensitive K (+) channel blocker) and tetraethylammonium [the non-selective Ca (2+)-activated K (+) (K (Ca)) channel blocker] but not by indomethacin (cyclooxygenase inhibitor), atropine (muscarinic receptor antagonist), (beta-adrenoceptor antagonist), and nifedipine (L-type voltage-gated Ca (2+) channel blocker), barium (inward rectifier K (+) channel inhibitor) and glibenclamide (ATP-sensitive K (+) channel blocker). |
0(0,0,0,0) | Details |
| 19171133 | Yaktubay Dondas N, Karatas Y, Kaya D, Soylu N, Singirik E, Baysal F: Molecular mechanism of KCl-induced relaxation of the esophagus. . Eur J Pharmacol. 2009 Mar 1;605(1-3):123-8. Epub 2009 Jan 10. Similarly, potassium channel blockers such as 4-aminopyridine (4-AP; 100 microM) and tetraethylammonium (TEA; 100 microM) caused a significant inhibition on relaxations to KCl. |
0(0,0,0,0) | Details |