| Name | catalase |
|---|---|
| Synonyms | CAT; Catalase; Erythrocyte derived growth promoting factor; Carnitine O acetyltransferase; Carnitine acetylase; Carnitine acetyltransferase; CAT; Catalases… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11313447 | Alcon S, Morales S, Camello PJ, Hemming JM, Jennings L, Mawe GM, Pozo MJ: A redox-based mechanism for the contractile and relaxing effects of NO in the guinea-pig gall bladder. J Physiol. 2001 May 1;532(Pt 3):793-810. The relaxations induced by either SIN-1 alone or SIN-1 in the presence of SOD were strengthened by catalase (1000 U ml (-1)) and abolished by ODQ pretreatment. These relaxations were sensitive to the guanylyl cyclase inhibitor 1H-[1,2,4] oxidiazolo [4,3-a] quinoxaline-1-one (ODQ, 2 microM) but they were not altered by treatment with the potassium channel blockers tetraethylammoniun (TEA, 5 mM) and 4-aminopyridine (4-AP, 5 mM). |
1(0,0,0,1) | Details |
| 14976323 | Erdos B, Simandle SA, Snipes JA, Miller AW, Busija DW: Potassium channel dysfunction in cerebral arteries of insulin-resistant rats is mediated by reactive species. Stroke. 2004 Apr;35(4):964-9. Epub 2004 Feb 19. Blockade of the K (ir) and K (v) channels with Ba2+ and 4-aminopyridine, respectively, constricted the MCAs in both experimental groups with no significant difference. Pretreatment of arteries with superoxide dismutase (200 U/mL) plus catalase (150 U/mL) restored the dilatory responses to iloprost and pinacidil in the IR arteries. |
1(0,0,0,1) | Details |
| 14597598 | Ellis A, Pannirselvam M, Anderson TJ, Triggle CR: Catalase has negligible inhibitory effects on endothelium-dependent relaxations in mouse isolated aorta and small mesenteric artery. Br J Pharmacol. 2003 Dec;140(7):1193-200. Epub 2003 Nov 3. H2O2-induced relaxations were endothelium-independent and were not affected by ethylene diamine tetraacetic acid (EDTA 0.067 mM), 4-aminopyridine (1 mM), ouabain (100 microM) and barium (30 microM), 3-AT or Indo. 6. |
1(0,0,0,1) | Details |
| 19917063 | Appiah I, Milovanovic S, Radojicic R, Nikolic-Kokic A, Orescanin-Dusic Z, Slavic M, Trbojevic S, Skrbic R, Spasic MB, Blagojevic D: peroxide affects contractile activity and anti-oxidant enzymes in rat uterus. Br J Pharmacol. 2009 Dec;158(8):1932-41. Epub . Anti-oxidative enzyme activities (manganese superoxide dismutase-MnSOD, -zinc superoxide dismutase-CuZnSOD, catalase-CAT, peroxidase-GSHPx and glutathione reductase-GR) in H (2) O (2)-treated uteri were compared with those in uteri immediately frozen after isolation or undergoing spontaneous or Ca (2+)-induced contractions, without treatment with H (2) O (2). The effect of inhibitors methylene blue, L-NAME, tetraethylamonium, glibenclamide and 4-aminopyridine) on H (2) O (2)-mediated relaxation was explored. |
1(0,0,0,1) | Details |
| 18001279 | Melis M, Enrico P, Peana AT, Diana M: mediates activation of the mesolimbic system. Eur J Neurosci. 2007 Nov;26(10):2824-33. EtOH-stimulating properties on DA neurons are prevented by pharmacological blockade of local catalase, the main metabolic step for biotransformation of EtOH into ACD in the central nervous system. |
1(0,0,0,1) | Details |
| 10658046 | Janssen LJ, Netherton SJ, Walters DK: Ca (2+)-dependent K (+) channels and Na (+)-K (+)-ATPase mediate H (2) O (2)- and -induced relaxations in canine trachealis. J Appl Physiol. 2000 Feb;88(2):745-52. These relaxations were eliminated by catalase but were much less sensitive to the scavenger dimethylthiourea, indicating they were mediated primarily by peroxide. These relaxations were decreased in magnitude and/or slowed by nifedipine (10 (-6) M), ouabain (10 (-6) M), or tetraethylammonium (25 mM), but not by 4-aminopyridine (5 mM), and were small or absent in tissues precontracted with 30 mM KCl. |
1(0,0,0,1) | Details |
| 11392467 | Ungvari Z, Koller A: reduces smooth muscle [Ca2+] i and constrictor responses of isolated arterioles. J Cardiovasc Pharmacol. 2001 Jun;37(6):705-12. The dilation was not affected by the presence of the synthase inhibitor Nomega-nitro- methyl ester or by removal of the endothelium, or the free radical scavenger catalase and superoxide dismutase, or the K+ channel inhibitors glibenclamide, 4-aminopyridine, or tetraethyl ammonium. |
0(0,0,0,0) | Details |
| 17624584 | Nacitarhan C, Bayram Z, Eksert B, Usta C, Golbasi I, Ozdem SS: The effect of peroxide in human internal thoracic arteries: role of channels, and cyclooxygenase products. Cardiovasc Drugs Ther. 2007 Aug;21(4):257-62. Incubation of endothelium-intact or endothelium-denuded human ITA rings with voltage-dependent potassium channel blocker 4-aminopyridine (5 mM) significantly inhibited the relaxant responses to H (2) O (2). |
0(0,0,0,0) | Details |
| 20089711 | Zoer B, Cogolludo AL, Perez-Vizcaino F, De Mey JG, Blanco CE, Villamor E: Hypoxia sensing in the fetal chicken femoral artery is mediated by the mitochondrial electron transport chain. Am J Physiol Regul Integr Comp Physiol. 2010 Apr;298(4):R1026-34. Epub 2010 Jan 20. The relaxation was enhanced in the presence of the voltage-gated K (+) channel blocker 4-aminopyridine. |
0(0,0,0,0) | Details |
| 17023676 | Saitoh S, Zhang C, Tune JD, Potter B, Kiyooka T, Rogers PA, Knudson JD, Dick GM, Swafford A, Chilian WM: peroxide: a feed-forward dilator that couples myocardial metabolism to coronary blood flow. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2614-21. Epub 2006 Oct 5. Aliquots of buffer from paced myocytes produced vasodilation of isolated arterioles (peak response 67+/-8% percent of maximal dilation) that was significantly reduced by catalase (5+/-0.5%, P <0.05) or the antagonist of Kv channels, 4-aminopyridine (18+/-4%, P <0.05). |
82(1,1,1,2) | Details |
| 17055466 | Cogolludo A, Frazziano G, Briones AM, Cobeno L, Moreno L, Lodi F, Salaices M, Tamargo J, Perez-Vizcaino F: The dietary activates BKCa currents in coronary arteries via production of H2O2. Cardiovasc Res. 2007 Jan 15;73(2):424-31. Epub 2006 Sep 20. These effects were abolished by the selective BKCa blocker iberiotoxin and by catalase. |
2(0,0,0,2) | Details |
| 16448858 | Iwasaki-Kurashige K, Loyaga-Rendon RY, Matsumoto H, Tokunaga T, Azuma H: Possible mediators involved in decreasing peripheral vascular resistance with blackcurrant concentrate (BC) in hind-limb perfusion model of the rat. Vascul Pharmacol. 2006 Apr;44(4):215-23. Epub 2006 Jan 30. The decrease in PP with BC was abolished by endothelial removal, nitroarginine plus tetraethylammonium, nitroarginine plus catalase or 1H-[1,2,4] oxadiazolo [4,3-a] quinoxaline-1-one as an inhibitor of guanylyl cyclase and potassium channel (s), and accompanied by the increased cyclic GMP level. |
2(0,0,0,2) | Details |
| 11463721 | Liu Y, Terata K, Rusch NJ, Gutterman DD: High glucose impairs voltage-gated K (+) channel current in rat small coronary arteries. Circ Res. 2001 Jul 20;89(2):146-52. Whole-cell patch clamping showed a reduction of 4-aminopyridine (4-AP)-sensitive current (Kv current) from smooth muscle cells of HG CAs versus NG CAs or versus LG CAs (peak density was 9.95+/-5.3 pA/pF for HG versus 27.8+/-6.8 pA/pF for NG and 28.5+/-5.2 pA/pF for LG; P <0.05). Partial restoration was observed with superoxide dismutase and catalase. |
2(0,0,0,2) | Details |
| 19617310 | Cogolludo AL, Moral-Sanz J, van der Sterren S, Frazziano G, van Cleef AN, Menendez C, Zoer B, Moreno E, Roman A, Perez-Vizcaino F, Villamor E: Maturation of O2 sensing and signaling in the chicken ductus arteriosus. . Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L619-30. Epub 2009 Jul 17. This contraction of the pDA was attenuated by inhibitors of the mitochondrial ETC and by the H (2) O (2) scavenger polyethylene glycol (PEG)-catalase. The K (V) channel blocker 4-aminopyridine prevented the current inhibition elicited by O (2). |
1(0,0,0,1) | Details |
| 10978056 | Iida Y, Katusic ZS: Mechanisms of cerebral arterial relaxations to peroxide. Stroke. 2000 Sep;31(9):2224-30. In the presence of a nonselective potassium channel inhibitor, BaCl (2) (10 (-4) mol/L), a delayed rectifier potassium channel inhibitor, 4-aminopyridine (10 (-3) mol/L), or a -activated potassium channel inhibitor, charybdotoxin (3 x 10 (-8) mol/L), the relaxations to peroxide were also significantly reduced. Catalase (1200 U/mL) abolished the relaxations to peroxide. |
1(0,0,0,1) | Details |