| Name | kininogen |
|---|---|
| Synonyms | Alpha 2 thiol proteinase inhibitor; BDK; Bradykinin; KNG; KNG 1; KNG1; Kininogen; Kininogen 1 precursor… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16042987 | Gendron G, Gobeil F Jr, Belanger S, Gagnon S, Regoli D, D'Orleans-Juste P: Urotensin II-induced hypotensive responses in Wistar-Kyoto (Wky) and spontaneously hypertensive (Shr) rats. Peptides. 2005 Aug;26(8):1468-74. These include the non-selective synthase inhibitor L-NAME (5 micromol/kg), the non-selective cyclooxygenase inhibitor meclofenamate (16 micromol/kg), the voltage-sensitive and ATP-sensitive K+-channel inhibitors, 4-aminopyridine (5 micromol/kg) and glybenclamide (10 micromol/kg), the cytochrome P450 CYP2C9 inhibitor sulfaphenazole (15 micromol/kg), the cytoskeletal fixation agent phalloidin (15 micromol/kg), the endothelin ETB receptor antagonist BQ-788 (35 micromol/kg), the bradykinin B2 receptor antagonist HOE 140 (0.5 micromol/kg), the angiotensin AT2 antagonist PD 123319 (10 micromol/kg) and the UT receptor antagonist urantide (10 micromol/kg). |
31(0,1,1,1) | Details |
| 15654262 | Fukada SY, Tirapelli CR, de Godoy MA, de Oliveira AM: Mechanisms underlying the endothelium-independent relaxation induced by angiotensin II in rat aorta. J Cardiovasc Pharmacol. 2005 Feb;45(2):136-43. The combination of L-NAME, indomethacin, and TEA completely abolished the relaxation induced by angiotensin II. 4-Aminopyridine (4-AP) as well as charybdotoxin reduced angiotensin II-induced relaxation. HOE-140, a selective antagonist of the bradykinin B2 receptor, and amiloride, a Na+/H+ exchanger inhibitor, abolished angiotensin II-induced relaxation. |
2(0,0,0,2) | Details |
| 16497109 | Gerova M, Kittova M: Systemic blood pressure response to the inhibition of two hyperpolarizing pathways: a comparison to NO-synthase inhibition. Physiol Res. 2006;55(6):603-10. After the inhibition of the action voltage-dependent K (+) channels operator by 4-aminopyridine 0.1 mg/100 g b.w. , the other hyperpolarizing pathway, blood pressure declined slightly from 132.3+/-3.2 mm Hg to 116.5+/-5.0 mm Hg, P <0.05 . After inhibition of the hyperpolarizing pathway by miconazole, hypotension induced by (Ach, 10 microg represented 63.0+/-1.9 mm Hg vs control value 78.6+/-5.2 mm Hg P <0.001 , by bradykinin (BK) 100 microg 59.4+/-3.9 mm Hg vs control value 71.2+/-6.1 mm Hg P <0.05 . |
1(0,0,0,1) | Details |
| 11522609 | Ohnishi Y, Hirano K, Nishimura J, Furue M, Kanaide H: Inhibitory effects of brefeldin A, a membrane transport blocker, on the bradykinin-induced hyperpolarization-mediated relaxation in the porcine coronary artery. Br J Pharmacol. 2001 Sep;134(1):168-78. The indomethacin/L-NOARG-resistant relaxation induced by bradykinin was completely inhibited by 3 mM tetrabutylammonium (non-specific Ca (2+)-activated K (+) channel blocker), while that induced by substance P was not inhibited by 3 mM tetrabutylammonium or 1 mM 4-aminopyridine (voltage-dependent K (+) channels blocker) alone, but completely inhibited by their combination. 5. |
3(0,0,0,3) | Details |
| 11312298 | Grimaldi M, Atzori M, Ray P, Alkon DL: Mobilization of from intracellular stores, potentiation of neurotransmitter-induced transients, and capacitative entry by 4-aminopyridine. J Neurosci. 2001 May 1;21(9):3135-43. In astrocytes, 4-AP treatment potentiated the sustained phase of the [Ca (2+)](i) elevation induced by ATP and bradykinin. |
1(0,0,0,1) | Details |
| 12626646 | Zhang Y, Tazzeo T, Hirota S, Janssen LJ: Vasodilatory and electrophysiological actions of 8-iso- in porcine coronary artery. J Pharmacol Exp Ther. 2003 Jun;305(3):1054-60. Epub 2003 Mar 6. The potency and efficacy of 8-iso- in reversing tone were not dependent upon the concentration of U46619 used to preconstrict the tissues (10 (-8) to 10 (-6) M), indicating a lack of U46619-induced functional antagonism of these responses. 8-iso- was able to completely relax tissues that had been denuded of endothelium (as indicated by loss of responsiveness to bradykinin). 8-iso--evoked relaxations were markedly reduced by elevating the K+ equilibrium potential using 30 mM KCl and abolished by 60 mM KCl; they were also sensitive to charybdotoxin (10 (-7) M) but not to 4-aminopyridine (1 mM). 8-iso- also caused membrane hyperpolarization and augmentation of outward K+ current. |
0(0,0,0,0) | Details |
| 16116333 | de Moura RS, Emiliano AF, de Carvalho LC, Souza MA, Guedes DC, Tano T, Resende AC: Antihypertensive and endothelium-dependent vasodilator effects of Alpinia zerumbet, a medicinal plant. J Cardiovasc Pharmacol. 2005 Sep;46(3):288-94. In vessels precontracted with the vasodilator effect of AZE was not changed by 4-aminopyridine, glibenclamide, or by charybdotoxin plus apamin. HOE 140, which significantly reduced the vasodilator effect of bradykinin, induced a slight but significant reduction on the vasodilator effect of AZE. |
2(0,0,0,2) | Details |
| 10763852 | Mazzuco TL, Andre E, Calixto JB: Contribution of prostanoids and Ca (2+)-activated K+ channels to the relaxant response of bradykinin in the guinea pig bronchus in vitro. Naunyn Schmiedebergs Arch Pharmacol. 2000 Apr;361(4):383-90. In contrast, 4-aminopyridine, apamin or glibenclamide did not affect BK-induced relaxation. |
2(0,0,0,2) | Details |
| 11159695 | Ishibashi H, Mochidome T, Okai J, Ichiki H, Shimada H, Takahama K: Activation of conductance by ophiopogonin-D in acutely dissociated rat paratracheal neurones. Br J Pharmacol. 2001 Jan;132(2):461-6. The I (OP-D) was blocked by an extracellular application of 1 mM Ba2+ by 59.0%, but other K (+) channel blockers, including 4-aminopyridine (3 mM), apamin (1 microM), charybdotoxin (0.3 microM), glibenclamide (1 microM), (0.3 mM) and tetraethylammonium (10 mM), did not inhibit the I (OP-D). 6. OP-D also inhibited the - and bradykinin-induced depolarizing responses which were accompanied with firing of action potentials. 7. |
1(0,0,0,1) | Details |
| 12969154 | Achar E, Achar RA, Paiva TB, Campos AH, Schor N: Amitriptyline eliminates calculi through urinary tract smooth muscle relaxation. Kidney Int. 2003 Oct;64(4):1356-64. This effect was prevented by pretreatment of urethral rings with 4-aminopyridine (4-AP), a voltage-dependent potassium channel blocker. Amitriptyline abolished in a reversible manner -, bradykinin-, and KCl-induced contractions in rat isolated bladder, and this effect was also prevented by 4-AP. |
1(0,0,0,1) | Details |
| 14757704 | Soares de Moura R, Resende AC, Emiliano AF, Tano T, Mendes-Ribeiro AC, Correia ML, de Carvalho LC: The role of bradykinin, AT2 and angiotensin 1-7 receptors in the EDRF-dependent vasodilator effect of angiotensin II on the isolated mesenteric vascular bed of the rat. Br J Pharmacol. 2004 Mar;141(5):860-6. Epub 2004 Feb 2. However, this effect is not affected by ATP and voltage-dependent K (+) channel blockers (glybenclamide and 4-aminopyridine). 5. |
1(0,0,0,1) | Details |
| 12742827 | Dantas AP, Igarashi J, Michel T: and control of vascular tone. Am J Physiol Heart Circ Physiol. 2003 Jun;284(6):H2045-52. S1P-induced vasodilation is abrogated by removal of endothelium or by the addition of the NOS inhibitor N (omega)-monomethyl- but is not affected by the cyclooxygenase inhibitor indomethacin, nor by the blockade of K (+) channels by using 4-aminopyridine. |
0(0,0,0,0) | Details |
| 16023862 | Madeira SV, de Castro Resende A, Ognibene DT, de Sousa MA, Soares de Moura R: Mechanism of the endothelium-dependent vasodilator effect of an -free extract obtained from a vinifera grape skin. Pharmacol Res. 2005 Oct;52(4):321-7. However, the vasodilator effect of GSE was unaffected by D-Arg [Hyp (3),Thi (5),D-Tic (7),Oic (8)] bradykinin (HOE-140), atropine, yohimbine, pyrilamine and 4-aminopyridine (4-AP). |
6(0,0,1,1) | Details |
| 12657746 | Bandara LR, Kelly MD, Lock EA, Kennedy S: A correlation between a proteomic evaluation and conventional measurements in the assessment of renal proximal tubular toxicity. Toxicol Sci. 2003 May;73(1):195-206. Epub 2003 Mar 25. Several isoforms of the rat-specific T-kininogen protein were identified in each study. |
4(0,0,0,4) | Details |