| Name | c fos |
|---|---|
| Synonyms | Cellular oncogene fos; FBJ murine osteosarcoma viral (v fos) oncogene homolog; FOS; G0/G1 switch regulatory protein 7; G0S7; Oncogene FOS; Proto oncogene protein c fos; c Fos… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17007911 | Fazekas I, Szakacs R, Mihaly A, Zador Z, Krisztin-Peva B, Juhasz A, Janka Z: Alterations of seizure-induced c-fos immunolabelling and gene expression in the rat cerebral cortex following dexamethasone treatment. Acta Histochem. 2006;108(6):463-73. Epub 2006 Sep 26. We examined the effects of dexamethasone on the expression of the inducible transcription factor c-fos in 4-aminopyridine (4-AP) seizures. |
10(0,0,1,5) | Details |
| 12948621 | Kovacs A, Mihaly A, Komaromi A, Gyengesi E, Szente M, Weiczner R, Krisztin-Peva B, Szabo G, Telegdy G: Seizure, neurotransmitter release, and gene expression are closely related in the striatum of 4-aminopyridine-treated rats. Epilepsy Res. 2003 Jun-Jul;55(1-2):117-29. The expression level of the c-fos gene was estimated by counting the striatal c-fos-immunostained cell nuclei at the time intervals of the microdialysis. 4-aminopyridine elicited high-frequency seizure discharges in the EEG and significantly increased and levels in the extracellular dialysates. |
10(0,0,1,5) | Details |
| 10802753 | Chen ZF, Schottler F, Bertram E, Gall CM, Anzivino MJ, Lee KS: Distribution and initiation of seizure activity in a rat brain with subcortical band heterotopia. Epilepsia. 2000 May;41(5):493-501. METHODS: Depth electrode recordings and postmortem assessment of regional c-fos mRNA levels were used to characterize the distribution of aberrant discharge activity during spontaneous seizures in vivo. Electrophysiologic recordings of spontaneous and evoked activity also were performed by using in vitro brain slices from the tish rat treated with proconvulsant drugs (penicillin and 4-aminopyridine). |
2(0,0,0,2) | Details |
| 16181416 | Kopniczky Z, Dobo E, Borbely S, Vilagi I, Detari L, Krisztin-Peva B, Bagosi A, Molnar E, Mihaly A: Lateral entorhinal cortex lesions rearrange afferents, glutamate receptors, increase seizure latency and suppress seizure-induced c-fos expression in the hippocampus of adult rat. J Neurochem. 2005 Oct;95(1):111-24. Here we analysed the effects of one-sided lateral EC (LEC) and temporoammonic (alvear) path lesion on the development and properties of 4-aminopyridine-induced seizures. |
2(0,0,0,2) | Details |
| 12576146 | Szakacs R, Weiczner R, Mihaly A, Krisztin-Peva B, Zador Z, Zador E: Non-competitive NMDA receptor antagonists moderate seizure-induced c-fos expression in the rat cerebral cortex. Brain Res Bull. 2003 Feb 15;59(6):485-93. We examined the effects of non-competitive glutamate receptor antagonists on seizures elicited by 4-aminopyridine (4-AP), and in particular, on the expression of the transcription factor c-fos induced by these seizures. |
34(0,1,1,4) | Details |
| 15829253 | Ogita K, Okuda H, Watanabe M, Nagashima R, Sugiyama C, Yoneda Y: In vivo treatment with the K+ channel blocker 4-aminopyridine protects against kainate-induced neuronal cell death through activation of NMDA receptors in murine hippocampus. Neuropharmacology. 2005 May;48(6):810-21. The systemic administration of the K+ channel blocker 4-aminopyridine (4-AP, 5 mg/kg, i.p.) induced expression of c-Fos in the hippocampal neuronal cell layer, which expression was completely abolished by the noncompetitive NMDA receptor antagonist MK-801, thus indicating that the administration of 4-AP would activate NMDA receptors in the hippocampal neurons. |
31(0,1,1,1) | Details |
| 15702242 | Mihaly A, Borbely S, Vilagi I, Detari L, Weiczner R, Zador Z, Krisztin-Peva B, Bagosi A, Kopniczky Z, Zador E: Neocortical c-fos mRNA transcription in repeated, brief, acute seizures: is c-fos a coincidence detector?. Int J Mol Med. 2005 Mar;15(3):481-6. The effect of acute brief seizures on neocortical c-fos expression was investigated in rats injected with 5 mg/kg 4-aminopyridine. |
9(0,0,1,4) | Details |
| 18036781 | Weiczner R, Krisztin-Peva B, Mihaly A: Blockade of AMPA-receptors attenuates 4-aminopyridine seizures, decreases the activation of inhibitory neurons but is ineffective against seizure-related astrocytic swelling. Epilepsy Res. 2008 Jan;78(1):22-32. Epub 2007 Nov 26. However, the effects on neuronal c-fos expression and astrocyte swelling were complex. |
4(0,0,0,4) | Details |
| 16533665 | Borbely S, Halasy K, Somogyvari Z, Detari L, Vilagi I: Laminar analysis of initiation and spread of epileptiform discharges in three in vitro models. Brain Res Bull. 2006 Mar 31;69(2):161-7. Epub 2005 Dec 19. Current source density (CSD) analysis or immunocytochemical c-Fos localization offer suitable tools to localize increased activation of neurons during seizure. |
3(0,0,0,3) | Details |
| 17005865 | Kalita K, Kharebava G, Zheng JJ, Hetman M: Role of megakaryoblastic acute leukemia-1 in ERK1/2-dependent stimulation of serum response factor-driven transcription by BDNF or increased synaptic activity. J Neurosci. 2006 Sep 27;26(39):10020-32. In neurons, endogenous MKL1 was associated with SRF-regulated chromatin regions of several endogenous genes including c-fos, JunB, Srf, and Cyr61. |
1(0,0,0,1) | Details |
| 11325566 | Mihaly A, Szakacs R, Bohata C, Dobo E, Krisztin-Peva B: Time-dependent distribution and neuronal localization of c-fos protein in the rat hippocampus following 4-aminopyridine seizures. Epilepsy Res. 2001 May;44(2-3):97-108. |
14(0,0,2,4) | Details |