| Name | TRAM |
|---|---|
| Synonyms | TRAM; TRAM1; TRAMP; Translocating chain associating membrane protein; Translocation associated membrane protein 1; Translocating chain associating membrane proteins; Translocation associated membrane protein 1s |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19406003 | Alda JO, Valero MS, Pereboom D, Gros P, Garay RP: Endothelium-independent vasorelaxation by the selective alpha estrogen receptor agonist propyl pyrazole triol in rat aortic smooth muscle. J Pharm Pharmacol. 2009 May;61(5):641-6. KEY FINDINGS: PPT vasorelaxation was largely reduced by the selective ERalpha antagonist methyl-piperidinopyrazole (MPP; -91.6+/-2.5%), by the selective PKG inhibitor Rp-8-Br- (-78.6+/-4.9%), by the specific soluble guanylyl cyclase inhibitor ODQ (1H-(1,2,4)-oxadiazolo [4,3-a] quinoxalin-1-one; -85.3+/-5.2%) and to a lesser extent by the selective BKCa (large-conductance - and voltage-activated potassium channel) inhibitor iberiotoxin (-59.3%), the selective IKCa (intermediate-conductance -activated potassium channel) inhibitor TRAM-34 (1-[(2-chlorophenyl) diphenylmethyl]-1H-pyrazole; -50.7%) and the voltage-gated potassium channel inhibitor 4-aminopyridine (-40.8%). |
31(0,1,1,1) | Details |
| 12684258 | Hinton JM, Langton PD: Inhibition of EDHF by two new combinations of K+-channel inhibitors in rat isolated mesenteric arteries. Br J Pharmacol. 2003 Mar;138(6):1031-5. It is widely established that in rat mesenteric arteries, endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation evoked by is abolished by a combination of charybdotoxin plus apamin. 4-Aminopyridine, an inhibitor of voltage-gated (Kv) K (+)-channels, in combination with apamin had moderate effects on the EDHF-mediated relaxation. EDHF-mediated vasorelaxation and hyperpolarization was abolished by a combination of TRAM-39 and apamin. |
2(0,0,0,2) | Details |
| 19680683 | Schilling T, Eder C: Lysophosphatidylcholine- and MCP-1-induced chemotaxis of monocytes requires potassium channel activity. Pflugers Arch. 2009 Nov;459(1):71-7. Epub 2009 Aug 14. Inhibition of voltage-gated K+ channels with 4-aminopyridine or margatoxin partially inhibited MCP-1- and LPC-stimulated migration of monocytes. Blockade of Ca2+-activated K+ channels with TRAM-34 also partially reduced migration of MCP-1- and LPC-stimulated monocytes. |
1(0,0,0,1) | Details |
| 16763288 | Dong H, Smith A, Hovaida M, Chow JY: Role of Ca2+-activated K+ channels in duodenal mucosal ion transport and secretion. Am J Physiol Gastrointest Liver Physiol. 2006 Dec;291(6):G1120-8. Epub 2006 Jun 8. Again, both and TRAM-34 significantly reduced A23187- or 1-EBIO-induced I (sc) and DMBS. Tetraethylammonium, 4-aminopyridine, and BaCl (2) failed to inhibit CCh-induced I (sc) and DMBS. |
1(0,0,0,1) | Details |
| 12456838 | Haddock RE, Hill CE: Differential activation of ion channels by (IP3)- and ryanodine-sensitive stores in rat basilar artery vasomotion. J Physiol. 2002 Dec 1;545(Pt 2):615-27. Ryanodine, charybdotoxin and TRAM-34, but not iberiotoxin, 4-aminopyridine or apamin, each depolarized SMCs and increased the frequency of rhythmical depolarizations and [Ca (2+)](i) oscillations. |
0(0,0,0,0) | Details |
| 17960514 | Oh KS, Ryu SY, Kim YS, Lee BH: Large conductance Ca2+-activated K+ (BKCa) channels are involved in the vascular relaxations elicited by isolated from Rheum undulatum rhizome. Planta Med. 2007 Nov;73(14):1441-6. Epub 2007 Oct 24. The -induced relaxation was also blocked by raising the extracellular K (+) (45 mM), 4-aminopyridine (voltage-sensitive K (+) channel blocker) and tetraethylammonium [the non-selective Ca (2+)-activated K (+) (K (Ca)) channel blocker] but not by indomethacin (cyclooxygenase inhibitor), atropine (muscarinic receptor antagonist), (beta-adrenoceptor antagonist), and nifedipine (L-type voltage-gated Ca (2+) channel blocker), barium (inward rectifier K (+) channel inhibitor) and glibenclamide (ATP-sensitive K (+) channel blocker). |
0(0,0,0,0) | Details |