Protein Information

Name parvalbumin
Synonyms D22S749; PVALB; Parvalbumin; Parvalbumin alpha; Parvalbumins; Parvalbumin alphas

Compound Information

Name 4-aminopyridine
CAS 4-pyridinamine

Reference List

PubMed Abstract RScore(About this table)
15530659 Vizi S, Bagosi A, Krisztin-Peva B, Gulya K, Mihaly A: Repeated 4-aminopyridine seizures reduce parvalbumin content in the medial mammillary nucleus of the rat brain. Brain Res Mol Brain Res. 2004 Nov 24;131(1-2):110-8.
166(2,2,2,6) Details
18377962 Bagosi A, Bakos M, Krisztin-Peva B, Mihaly A: Late expression of FosB transcription factor in 4-aminopyridine-induced seizures in the rat cerebral cortex. Acta Histochem. 2008;110(5):418-26. Epub 2008 Apr 2.

The neuronal localization of FosB after 12 days of 4-aminopyridine-induced convulsions was analysed by means of FosB-parvalbumin double immunolabelling.
6(0,0,1,1) Details
20083165 Henderson Z, Lu CB, Janzso G, Matto N, McKinley CE, Yanagawa Y, Halasy K: Distribution and role of Kv3.1b in neurons in the medial septum diagonal band complex. Neuroscience. 2010 Mar 31;166(3):952-69. Epub 2010 Jan 18.

In the MS/DB we have previously described a population of fast spiking GABAergic neurons that contain parvalbumin and mediate theta frequency activity in vitro.
The results for the MS/DB were as follows: (1) cholinergic cells did not express GFP in either GAD67-GFP or VGluT2-GFP mice, and there was GAD67 immunoreactivity in GFP-positive neurons in GAD67-GFP mice and in a small proportion (6%) of GFP-positive neurons in VGluT2-GFP mice. (2) Kv3.1b immunofluorescence was associated with the somata of GABAergic neurons, especially those that contained parvalbumin, and with a minority of glutamatergic neurons, but not with cholinergic neurons, and with GABAergic axonal terminal-like processes around certain GABAergic neurons. (3) Both Kv3.1b-positive and -negative GABAergic neurons were septo-hippocampal, and there was a minor projection to hippocampus from VGluT2-GFP neurons. (4) Kainate-induced theta oscillations in the MS/DB slice were potentiated rather than inhibited by the Kv3.1 blocker 4-aminopyridine, and this agent on its own produced theta frequency oscillations in MS/DB slices that were reduced by ionotropic glutamate and GABA receptor antagonists and abolished by low extracellular calcium.
1(0,0,0,1) Details
18036781 Weiczner R, Krisztin-Peva B, Mihaly A: Blockade of AMPA-receptors attenuates 4-aminopyridine seizures, decreases the activation of inhibitory neurons but is ineffective against seizure-related astrocytic swelling. Epilepsy Res. 2008 Jan;78(1):22-32. Epub 2007 Nov 26.

Investigation of the neocortical parvalbumin-containing interneuron population proved that GYKI 52466 decreased c-fos expression.
1(0,0,0,1) Details
16690210 Zappala A, Cicero D, Serapide MF, Paz C, Catania MV, Falchi M, Parenti R, Panto MR, La Delia F, Cicirata F: Expression of pannexin1 in the CNS of adult mouse: cellular localization and effect of 4-aminopyridine-induced seizures. Neuroscience. 2006 Aug 11;141(1):167-78. Epub 2006 May 11.

Cells positive to Ca-binding proteins, principally parvalbumin, but also calbindin and calretinin, as well as glutamate decarboxylase 67 kDa isoform, were pannexin1-positive.
1(0,0,0,1) Details
11325566 Mihaly A, Szakacs R, Bohata C, Dobo E, Krisztin-Peva B: Time-dependent distribution and neuronal localization of c-fos protein in the rat hippocampus following 4-aminopyridine seizures. Epilepsy Res. 2001 May;44(2-3):97-108.

The activated neuronal assemblies were analyzed with the aid of parvalbumin c-fos double immunostaining.
1(0,0,0,1) Details
19741102 Sun QQ: Experience-dependent intrinsic plasticity in interneurons of barrel cortex layer IV. J Neurophysiol. 2009 Nov;102(5):2955-73. Epub 2009 Sep 9.


Along with changes in the intrinsic properties of FS cells, whisker trimming also induced a robust reduction in the number of vesicular glutamate transporter 2 positive varicosities and parvalbumin expression and the strength of thalamocortical (TC) excitatory postsynaptic currents in FS cells in the "sensory-deprived barrels." The probability of spike induction by TC stimulus was reduced by 30% and the spike jitter was increased in sensory-deprived FS cells.
1(0,0,0,1) Details