Protein Information

Name gephyrin
Synonyms GEPH; GPH; GPHN; GPHRYN; Gephyrin; MLL/GPH fusion gene; Gephyrins; MLL/GPH fusion genes

Compound Information

Name 4-aminopyridine
CAS 4-pyridinamine

Reference List

PubMed Abstract RScore(About this table)
16641238 Hanus C, Ehrensperger MV, Triller A: Activity-dependent movements of postsynaptic scaffolds at inhibitory synapses. J Neurosci. 2006 Apr 26;26(17):4586-95.

Moreover, the action of the potassium channel blocker 4-aminopyridine and receptor antagonists indicate that the dynamics of postsynaptic gephyrin scaffolds are controlled by synaptic activity.
83(1,1,1,3) Details
15233752 Marty S, Wehrle R, Fritschy JM, Sotelo C: Quantitative effects produced by modifications of neuronal activity on the size of GABAA receptor clusters in hippocampal slice cultures. Eur J Neurosci. 2004 Jul;20(2):427-40.

Slices from P7 rat hippocampus were cultured for 13 days in the presence of bicuculline or 4-aminopyridine (4-AP) to increase neuronal activity, or DNQX to decrease activity.
The changes provoked by these treatments on clusters immunoreactive for the alpha1 and alpha2 subunits of the GABA (A) receptor or gephyrin were quantitatively evaluated.
2(0,0,0,2) Details