Protein Information

Name KCNQ1
Synonyms ATFB 1; KCNA 8; KCNA8; ATFB1; IKs producing slow voltage gated potassium channel alpha subunit KvLQT1; IKs producing slow voltage gated potassium channel subunit alpha KvLQT1; JLNS 1; JLNS1…

Compound Information

Name 4-aminopyridine
CAS 4-pyridinamine

Reference List

PubMed Abstract RScore(About this table)
12690036 Ohya S, Sergeant GP, Greenwood IA, Horowitz B: Molecular variants of KCNQ channels expressed in murine portal vein myocytes: a role in delayed rectifier current. Circ Res. 2003 May 16;92(9):1016-23. Epub 2003 Apr 10.


We have analyzed the expression of KCNQ genes in murine portal vein myocytes and determined that of the 5 known KCNQ channels, only KCNQ1 was expressed.
3(0,0,0,3) Details
12395204 Bertaso F, Sharpe CC, Hendry BM, James AF: Expression of voltage-gated K+ channels in human atrium. Basic Res Cardiol. 2002 Nov;97(6):424-33.

Both I (to1) and I (so) were inhibited by high concentrations (2 mM) of the K (+) channel blocker, 4-aminopyridine (4-AP).
We used a semi-quantitative RT-PCR technique to examine the relative expression of mRNAs for the voltage-gated K (+) channel subunits, Kv1.2, Kv1.4, Kv1.5, Kv2.1, Kv4.2, Kv4.3, KvLQT1, HERG and IsK in samples of human atrial appendage.
3(0,0,0,3) Details
16133261 Ullrich S, Su J, Ranta F, Wittekindt OH, Ris F, Rosler M, Gerlach U, Heitzmann D, Warth R, Lang F: Effects of I (Ks) channel inhibitors in insulin-secreting INS-1 cells. Pflugers Arch. 2005 Dec;451(3):428-36. Epub 2005 Aug 30.


We examined whether KCNQ1 channels are expressed in pancreatic beta-cells and analysed their functional role.
2(0,0,0,2) Details
11752222 Mason DE, Mitchell KE, Li Y, Finley MR, Freeman LC: Molecular basis of voltage-dependent potassium currents in porcine granulosa cells. Mol Pharmacol. 2002 Jan;61(1):201-13.

Two delayed rectifier K (+) currents with distinct electrophysiological and pharmacological properties were recorded from porcine GC by using whole-cell patch clamp: 1) a slowly activating, noninactivating current (I (Ks)) antagonized by clofilium, 293B, L-735,821, and L-768,673; and 2) an ultrarapidly activating, slowly inactivating current (I (Kur)) antagonized completely by clofilium and 4-aminopyridine and partially by tetraethylammonium, charybdotoxin, dendrotoxin, and kaliotoxin.
We found that GC could express multiple voltage-dependent K (+) (Kv) channel subunits, including KCNQ1, KCNE1, Kv1.1, Kv1.2, Kv1.3, Kv1.4, Kv1.5, Kv1.6, Kvbeta1.3, and Kvbeta2.
2(0,0,0,2) Details
10779469 Yamashita T, Murakawa Y, Hayami N, Fukui E, Kasaoka Y, Inoue M, Omata M: Short-term effects of rapid pacing on mRNA level of voltage-dependent K (+) channels in rat atrium: electrical remodeling in paroxysmal atrial tachycardia. Circulation. 2000 Apr 25;101(16):2007-14.

Electrophysiological findings that the shortening of the action potential produced by 4-hour pacing was almost abolished by a low concentration of 4-aminopyridine implied that the increased Kv1.5 protein was functioning.
Total RNA was prepared from the atrial appendages from 0 to 8 hours after the onset of pacing, and mRNA levels of Kv1.2, Kv1. 4, Kv1.5, Kv2.1, Kv4.2, Kv4.3, erg, KvLQT1, and minK were determined by RNase protection assay.
1(0,0,0,1) Details
17519950 Yeung SY, Pucovsky V, Moffatt JD, Saldanha L, Schwake M, Ohya S, Greenwood IA: Molecular expression and pharmacological identification of a role for K (v) 7 channels in murine vascular reactivity. Br J Pharmacol. 2007 Jul;151(6):758-70. Epub 2007 May 21.

KEY RESULTS: All blood vessels expressed KCNQ1, 4 and 5 with hitherto 'neuronal' KCNQ4 being, surprisingly, the most abundant.
Application of three compounds known to activate K (v) 7 channels, retigabine (2 -20 microM), flupirtine (20 microM) and meclofenamic acid (20 microM), relaxed vessels precontracted by phenylephrine or 1 mM 4-aminopyridine but had no effect on contractions produced by 60 mM KCl or the K (v) 7 channel blocker XE991 (10 microM).
1(0,0,0,1) Details