Name | KCNQ1 |
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Synonyms | ATFB 1; KCNA 8; KCNA8; ATFB1; IKs producing slow voltage gated potassium channel alpha subunit KvLQT1; IKs producing slow voltage gated potassium channel subunit alpha KvLQT1; JLNS 1; JLNS1… |
Name | 4-aminopyridine |
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CAS | 4-pyridinamine |
PubMed | Abstract | RScore(About this table) | |
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12690036 | Ohya S, Sergeant GP, Greenwood IA, Horowitz B: Molecular variants of KCNQ channels expressed in murine portal vein myocytes: a role in delayed rectifier current. Circ Res. 2003 May 16;92(9):1016-23. Epub 2003 Apr 10. We have analyzed the expression of KCNQ genes in murine portal vein myocytes and determined that of the 5 known KCNQ channels, only KCNQ1 was expressed. |
3(0,0,0,3) | Details |
12395204 | Bertaso F, Sharpe CC, Hendry BM, James AF: Expression of voltage-gated K+ channels in human atrium. Basic Res Cardiol. 2002 Nov;97(6):424-33. Both I (to1) and I (so) were inhibited by high concentrations (2 mM) of the K (+) channel blocker, 4-aminopyridine (4-AP). We used a semi-quantitative RT-PCR technique to examine the relative expression of mRNAs for the voltage-gated K (+) channel subunits, Kv1.2, Kv1.4, Kv1.5, Kv2.1, Kv4.2, Kv4.3, KvLQT1, HERG and IsK in samples of human atrial appendage. |
3(0,0,0,3) | Details |
16133261 | Ullrich S, Su J, Ranta F, Wittekindt OH, Ris F, Rosler M, Gerlach U, Heitzmann D, Warth R, Lang F: Effects of I (Ks) channel inhibitors in insulin-secreting INS-1 cells. Pflugers Arch. 2005 Dec;451(3):428-36. Epub 2005 Aug 30. We examined whether KCNQ1 channels are expressed in pancreatic beta-cells and analysed their functional role. |
2(0,0,0,2) | Details |
11752222 | Mason DE, Mitchell KE, Li Y, Finley MR, Freeman LC: Molecular basis of voltage-dependent Two delayed rectifier K (+) currents with distinct electrophysiological and pharmacological properties were recorded from porcine GC by using whole-cell patch clamp: 1) a slowly activating, noninactivating current (I (Ks)) antagonized by clofilium, 293B, L-735,821, and L-768,673; and 2) an ultrarapidly activating, slowly inactivating current (I (Kur)) antagonized completely by clofilium and 4-aminopyridine and partially by tetraethylammonium, charybdotoxin, dendrotoxin, and kaliotoxin. We found that GC could express multiple voltage-dependent K (+) (Kv) channel subunits, including KCNQ1, KCNE1, Kv1.1, Kv1.2, Kv1.3, Kv1.4, Kv1.5, Kv1.6, Kvbeta1.3, and Kvbeta2. |
currents in porcine granulosa cells. Mol Pharmacol. 2002 Jan;61(1):201-13.2(0,0,0,2) | Details |
10779469 | Yamashita T, Murakawa Y, Hayami N, Fukui E, Kasaoka Y, Inoue M, Omata M: Short-term effects of rapid pacing on mRNA level of voltage-dependent K (+) channels in rat atrium: electrical remodeling in paroxysmal atrial tachycardia. Circulation. 2000 Apr 25;101(16):2007-14. Electrophysiological findings that the shortening of the action potential produced by 4-hour pacing was almost abolished by a low concentration of 4-aminopyridine implied that the increased Kv1.5 protein was functioning. Total RNA was prepared from the atrial appendages from 0 to 8 hours after the onset of pacing, and mRNA levels of Kv1.2, Kv1. 4, Kv1.5, Kv2.1, Kv4.2, Kv4.3, erg, KvLQT1, and minK were determined by RNase protection assay. |
1(0,0,0,1) | Details |
17519950 | Yeung SY, Pucovsky V, Moffatt JD, Saldanha L, Schwake M, Ohya S, Greenwood IA: Molecular expression and pharmacological identification of a role for K (v) 7 channels in murine vascular reactivity. Br J Pharmacol. 2007 Jul;151(6):758-70. Epub 2007 May 21. KEY RESULTS: All blood vessels expressed KCNQ1, 4 and 5 with hitherto 'neuronal' KCNQ4 being, surprisingly, the most abundant. Application of three compounds known to activate K (v) 7 channels, retigabine (2 -20 microM), flupirtine (20 microM) and meclofenamic acid (20 microM), relaxed vessels precontracted by or 1 mM 4-aminopyridine but had no effect on contractions produced by 60 mM KCl or the K (v) 7 channel blocker XE991 (10 microM). |
1(0,0,0,1) | Details |