| Name | caspase (protein family or complex) |
|---|---|
| Synonyms | caspase; caspases |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11586111 | Dumont RJ, Verma S, Okonkwo DO, Hurlbert RJ, Boulos PT, Ellegala DB, Dumont AS: Acute spinal cord injury, part II: contemporary pharmacotherapy. Clin Neuropharmacol. 2001 Sep-Oct;24(5):265-79. Myriad treatment modalities, including corticosteroids, 21-aminosteroids, opioid receptor antagonists, gangliosides, (TRH) and TRH analogs, antioxidants and free radical scavengers, calcium channel blockers, replacement therapy, sodium channel blockers, N -methyl-D- receptor antagonists, alpha-amino-3--5-methylisoxazole-4--kainate receptor antagonists, modulators of arachadonic acid metabolism, neurotrophic growth factors, antagonists, antibodies against inhibitors of axonal regeneration, potassium channel blockers (4-aminopyridine), paclitaxel, clenbuterol, gabexate mesylate, activated protein C, caspase inhibitors, tacrolimus, antibodies against adhesion molecules, and other immunomodulatory therapy have been studied to date. |
31(0,1,1,1) | Details |
| 16020659 | Grishin A, Ford H, Wang J, Li H, Salvador-Recatala V, Levitan ES, Zaks-Makhina E: Attenuation of apoptosis in enterocytes by blockade of channels. Am J Physiol Gastrointest Liver Physiol. 2005 Nov;289(5):G815-21. Epub 2005 Jul 14. Blockade of K+ efflux with tetraethylammonium, 4-aminopyridine, stromatoxin, chromanol 293B, and the recently described K+ channel inhibitor 48F10 prevents DNA fragmentation, caspase activation, release of cytochrome c from mitochondria, and loss of mitochondrial membrane potential. |
81(1,1,1,1) | Details |
| 16019148 | Han P, Lucero MT: Pituitary adenylate cyclase activating polypeptide reduces A-type K+ currents and caspase activity in cultured adult mouse olfactory neurons. Neuroscience. 2005;134(3):745-56. Our observation that 5 mM 4-aminopyridine mimicked the caspase inhibiting effects of pituitary adenylate cyclase activating polypeptide indicates that A-type current is involved in apoptosis. |
35(0,1,1,5) | Details |
| 12734105 | Ekhterae D, Platoshyn O, Zhang S, Remillard CV, Yuan JX: Apoptosis repressor with caspase domain inhibits cardiomyocyte apoptosis by reducing K+ currents. Am J Physiol Cell Physiol. 2003 Jun;284(6):C1405-10. Epub 2003 Jan 29. Extracellular application of 5 mM 4-aminopyridine (4-AP), a blocker of Kv channels, reversibly reduced I (K (V)) by 50-60% in H9c2 cells. |
2(0,0,0,2) | Details |
| 11557592 | Krick S, Platoshyn O, McDaniel SS, Rubin LJ, Yuan JX: Augmented K (+) currents and mitochondrial membrane depolarization in pulmonary artery myocyte apoptosis. Am J Physiol Lung Cell Mol Physiol. 2001 Oct;281(4):L887-94. The mitochondrial membrane depolarization would cause cytochrome c release, activate the cytosolic caspases, and induce apoptosis. Blockade of K (V) channels with 4-aminopyridine diminished I (K (V)) and markedly decreased the ST-mediated apoptosis. |
1(0,0,0,1) | Details |
| 12606650 | Wang XQ, Xiao AY, Yang A, LaRose L, Wei L, Yu SP: Block of Na+,K+-ATPase and induction of hybrid death by 4-aminopyridine in cultured cortical neurons. J Pharmacol Exp Ther. 2003 May;305(2):502-6. Epub 2003 Jan 21. At similar concentrations, 4-AP induced a neuronal death sensitive to attenuation by the caspase inhibitor Z-VAD-FMK (Z-Val--Asp (OMe)-fluoromethyl ketone) or Ca (2+) chelator BAPTA-AM (1,2-bis (2-aminophenoxy) ethane-N,N,N',N'-tetraacetic acid-acetoxymethyl ester). |
1(0,0,0,1) | Details |