Protein Information

Name ERK2
Synonyms ERK; P40; ERK 2; ERK2; ERT 1; ERT1; Extracellular signal regulated kinase 2; MAP kinase 2…

Compound Information

Name 4-aminopyridine
CAS 4-pyridinamine

Reference List

PubMed Abstract RScore(About this table)
11412897 Wong M, Yamada KA: Developmental characteristics of epileptiform activity in immature rat neocortex: a comparison of four in vitro seizure models. Brain Res Dev Brain Res. 2001 Jun 29;128(2):113-20.

The present study investigated developmental changes in epileptiform activity in rat neocortical slices from four age groups (postnatal days P4--7, P13--16, P23--26, P41--47) due to four pharmacological conditions (4-aminopyridine, low magnesium, picrotoxin, CGP-35348) that differentially modulate glutamate and GABA systems.
31(0,1,1,1) Details
15086522 Merlo D, Cifelli P, Cicconi S, Tancredi V, Avoli M: 4-Aminopyridine-induced epileptogenesis depends on activation of mitogen-activated protein kinase ERK. J Neurochem. 2004 May;89(3):654-9.

Extracellular signal-regulated kinases such as ERK1 [p44 mitogen-activated protein kinase (MAPK)] and ERK2 (p42 MAPK) are activated in the CNS under physiological and pathological conditions such as ischemia and epilepsy.
1(0,0,0,1) Details