| Name | endothelin 1 |
|---|---|
| Synonyms | EDN 1; EDN1; ET1; Endothelin 1; Endothelin 1 precursor; PPET 1; PPET1; Preproendothelin 1… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11588116 | MacLean MR, Morecroft I: Increased contractile response to 5-hydroxytryptamine1-receptor stimulation in pulmonary arteries from chronic hypoxic rats: role of pharmacological synergy. Br J Pharmacol. 2001 Oct;134(3):614-20. Here we investigate the influence of vascular tone induced by endothelin-1 (ET-1), neuropeptide Y (NPY), KCl, 4-aminopyridine (inactivator of K (v) channels, 4-AP) or the ionophore A23187 on contractile responses to the (1)-receptor agonist 5-carboxamidotryptamine (5-CT) in small muscular pulmonary arteries from control rats and rats exposed to chronic hypoxia. |
31(0,1,1,1) | Details |
| 19033883 | Van der Sterren S, Agren P, Zoer B, Kessels L, Blanco CE, Villamor E: Morphological and functional alterations of the ductus arteriosus in a chicken model of hypoxia-induced fetal growth retardation. Pediatr Res. 2009 Mar;65(3):279-84. The ductal contractions induced by KCl, H2O2, 4-aminopyridine, and endothelin-1 were similar in control and hypoxic fetuses. |
6(0,0,1,1) | Details |
| 10864884 | Betts LC, Kozlowski RZ: Electrophysiological effects of endothelin-1 and their relationship to contraction in rat renal arterial smooth muscle. Br J Pharmacol. 2000 Jun;130(4):787-96. |
2(0,0,0,2) | Details |
| 11597902 | Shimoda LA, Sylvester JT, Booth GM, Shimoda TH, Meeker S, Undem BJ, Sham JS: Inhibition of voltage-gated K (+) currents by endothelin-1 in human pulmonary arterial myocytes. Am J Physiol Lung Cell Mol Physiol. 2001 Nov;281(5):L1115-22. K (V) currents were isolated by addition of 100 nM charybdotoxin and were identified by current characteristics and inhibition by 4-aminopyridine (10 mM). |
2(0,0,0,2) | Details |
| 18689502 | Xu M, Remillard CV, Sachs BD, Makino A, Platoshyn O, Yao W, Dillmann WH, Akassoglou K, Yuan JX: p75 neurotrophin receptor regulates agonist-induced pulmonary vasoconstriction. Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1529-38. Epub 2008 Aug 8. Pulmonary artery rings from p75 (-/-) mice exhibited significantly elevated active tension due to endothelin-1-mediated Ca (2+) influx. Active tension induced by U-46619 (a A (2) analog), thrombin, 4-aminopyridine (a K (+) channel blocker), and high extracellular K (+) in p75 (-/-) rings was similar to that in WT rings. |
2(0,0,0,2) | Details |
| 10926549 | Sham JS, Crenshaw BR Jr, Deng LH, Shimoda LA, Sylvester JT: Effects of hypoxia in porcine pulmonary arterial myocytes: roles of K (V) channel and endothelin-1. Am J Physiol Lung Cell Mol Physiol. 2000 Aug;279(2):L262-72. Inhibition of voltage-dependent K (+) (K (V)) channel with 4-aminopyridine produced a greater increase in [Ca (2+)](i) in distal than in proximal PASMCs. |
2(0,0,0,2) | Details |
| 15127573 | Fan ZW, Zhang ZX, Xu YJ: [Inhibition of voltage-gated K+ current in rat intrapulmonary arterial smooth muscle cells by endothelin-1]. Yao Xue Xue Bao. 2004 Jan;39(1):9-12. RESULTS: ET-1 (1 x 10 (-9) mol.L-1) and the voltage-dependent K+ (KV)-channel antagonist 4-aminopyridine (4AP), but not the Ca (2+)-activated K (+)-channel antagonist tetraethylammonium (TEA), caused membrane depolarization. |
2(0,0,0,2) | Details |
| 15749740 | Gao Y, Raj JU: Parathyroid hormone-related protein-mediated responses in pulmonary arteries and veins of newborn lambs. Am J Physiol Lung Cell Mol Physiol. 2005 Jul;289(1):L60-6. Epub 2005 Mar 4. In vessels constricted with endothelin-1, PTHrP (PTHrP 1-34) caused greater relaxation of veins than of arteries. However, relaxation was attenuated by 4-aminopyridine, inhibitor of voltage-dependent channels, in both arteries and veins, and by charybdotoxin, inhibitor of -activated channels, in veins. |
1(0,0,0,1) | Details |
| 14724755 | Roderick C, Reinach PS, Wang L, Lu L: Modulation of rabbit corneal epithelial cell proliferation by growth factor-regulated K (+) channel activity. J Membr Biol. 2003 Nov 1;196(1):41-50. Exposure of starved cells to either 10% FBS, 5 ng/ml epidermal growth factor (EGF) or 2 n M endothelin-1 (ET-1) continuously increased its activity within 30 min by 40%, 54% and 29%, respectively. Application of 100 micro M 4-aminopyridine (4-AP), a K (+) channel blocker, inhibited serum-stimulated K (+) channel activity by 85%. |
1(0,0,0,1) | Details |
| 17526655 | Yang Y, Jones AW, Thomas TR, Rubin LJ: Influence of sex, high-fat diet, and exercise training on currents of swine coronary smooth muscle. Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1553-63. Epub 2007 May 25. In the presence of endothelin-1, 1) I (K (KV)) was similar in SED males and females and EX increased I (K (KV)) to a greater extent in males than in females and 2) I (K (BK)) was greater in SED females than in males and EX increased I (K (BK)) to a greater extent in males, resulting in I (K (BK)) similar to EX females. VSM cells of normal-diet SED animals exhibited three components of I (K): 4-aminopyridine-sensitive I (K (KV)), TEA-sensitive I (K (BK)), and 4-aminopyridine + TEA-insensitive I (K). |
1(0,0,0,1) | Details |
| 17267549 | Remillard CV, Tigno DD, Platoshyn O, Burg ED, Brevnova EE, Conger D, Nicholson A, Rana BK, Channick RN, Rubin LJ, O'connor DT, Yuan JX: Function of Kv1.5 channels and genetic variations of KCNA5 in patients with idiopathic pulmonary arterial hypertension. Am J Physiol Cell Physiol. 2007 May;292(5):C1837-53. Epub 2007 Jan 31. Here, we report that overexpression of the Kv1.5 channel gene (KCNA5) in human PASMC and other cell lines produced a 15-pS single channel current and a large whole cell current that was sensitive to 4-aminopyridine. Extracellular application of bepridil, correolide, and endothelin-1 (ET-1) all significantly and reversibly reduced the Kv1.5 currents, while and bepridil also accelerated the inactivation kinetics of the currents. |
1(0,0,0,1) | Details |
| 17982012 | Xu M, Platoshyn O, Makino A, Dillmann WH, Akassoglou K, Remillard CV, Yuan JX: Characterization of agonist-induced vasoconstriction in mouse pulmonary artery. Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H220-8. Epub 2007 Nov 2. These arteries are also reactive to stimulation by alpha (1)-adrenergic agonists, endothelin-1, and U-46619 (a A (2) analog). |
1(0,0,0,1) | Details |
| 11483700 | Cheong A, Dedman AM, Beech DJ: Expression and function of native potassium channel [K (V) alpha1] subunits in terminal arterioles of rabbit. J Physiol. 2001 Aug 1;534(Pt 3):691-700. Current activated on depolarisation positive of about -45 mV and a large fraction of this current was blocked by 3,4-diaminopyridine (3,4-DAP) or 4-aminopyridine (4-AP), inhibitors of K (V) channels. |
0(0,0,0,0) | Details |
| 20164203 | Flinsenberg TW, Van der Sterren S, van Cleef AN, Schuurman MJ, Agren P, Villamor E: Effects of gender and on chicken ductus arteriosus reactivity. Am J Physiol Regul Integr Comp Physiol. 2010 Feb 17. In vitro contractions (assessed with a wire myograph) induced by normoxia, KCl, 4-aminopyridine, U46619, or endothelin-1 as well as relaxations induced by sodium nitroprusside, BAY 41-2272, isoproterenol, forskolin,Y-27632, and hydroxyfasudil were not significantly different between males and females. |
0(0,0,0,0) | Details |
| 15678081 | Mraiche F, Cena J, Das D, Vollrath B: Effects of statins on vascular function of endothelin-1. . Br J Pharmacol. 2005 Mar;144(5):715-26. Pretreatment with the Kv channels inhibitor, 4-aminopyridine, attenuated the ability of SV to relax contractions mediated by ET-1 and NA. 7. |
1(0,0,0,1) | Details |
| 10963252 | Michelakis E, Rebeyka I, Bateson J, Olley P, Puttagunta L, Archer S: Voltage-gated potassium channels in human ductus arteriosus. . Lancet. 2000 Jul 8;356(9224):134-7. We studied tone in the human ductus arteriosus and show that the constriction to is due to inhibition of voltage-gated potassium channels and, in the acute phase, is independent of endothelin-1. |
1(0,0,0,1) | Details |
| 12933338 | Gupte SA, Arshad M, Viola S, Kaminski PM, Ungvari Z, Rabbani G, Koller A, Wolin MS: Pentose phosphate pathway coordinates multiple redox-controlled relaxing mechanisms in bovine coronary arteries. Am J Physiol Heart Circ Physiol. 2003 Dec;285(6):H2316-26. Epub 2003 Aug 21. High doses of K+ channel blockers [e.g., TEA (10 mM) and 4-aminopyridine (10 mM)] only partially inhibited the relaxation to 6-AN. |
0(0,0,0,0) | Details |