| Name | GABA at |
|---|---|
| Synonyms | (S) 3 amino 2 methylpropionate transaminase; 4 aminobutyrate aminotransferase; ABAT; ABAT protein; GABA aminotransferase; GABA transaminase; GABA AT; GABA T… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11113304 | Pena F, Tapia R: Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of - and -mediated neurotransmission and of ion channels. Neuroscience. 2000;101(3):547-61. None of the drugs facilitating -mediated transmission, including uptake blockers, GABA-transaminase inhibitors and agonists of the A-type receptor, was able to reduce the release, seizures or neuronal damage produced by 4-aminopyridine. |
31(0,1,1,1) | Details |
| 19955357 | Markwardt SJ, Wadiche JI, Overstreet-Wadiche LS: Input-specific GABAergic signaling to newborn neurons in adult dentate gyrus. J Neurosci. 2009 Dec 2;29(48):15063-72. Rather, our results suggest that slow synaptic responses in newborn GCs are generated by dedicated inputs that produce a relatively low concentration of GABA at postsynaptic receptors, similar to slow IPSCs in mature GCs. |
1(0,0,0,1) | Details |
| 15939088 | DeFazio RA, Hablitz JJ: Horizontal spread of activity in neocortical inhibitory networks. Brain Res Dev Brain Res. 2005 Jun 9;157(1):83-92. Epub 2005 Apr 19. In the presence of 4-aminopyridine (4-AP) and excitatory amino acid receptor blockers, GABAergic networks in the neocortex give rise to large spontaneous -mediated depolarizations. Taken together, these data support a role for both direct synaptic action of GABA at (A) receptors and nonsynaptic mechanisms in the generation and propagation of depolarizing responses. |
1(0,0,0,1) | Details |