| Name | KChIP2 |
|---|---|
| Synonyms | A type potassium channel modulatory protein 2; Cardiac voltage gated potassium channel modulatory subunit; KCHIP 2; KCHIP2; KCNIP 2; KCNIP2; Kv channel interacting protein 2; Potassium channel interacting protein 2… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17242957 | Schultz JH, Volk T, Bassalay P, Hennings JC, Hubner CA, Ehmke H: Molecular and functional characterization of Kv4.2 and KChIP2 expressed in the porcine left ventricle. Pflugers Arch. 2007 May;454(2):195-207. Epub 2007 Jan 23. |
6(0,0,0,6) | Details |
| 15937516 | Iida H, Jo T, Iwasawa K, Morita T, Hikiji H, Takato T, Toyo-Oka T, Nagai R, Nakajima T: Molecular and pharmacological characteristics of transient voltage-dependent K+ currents in cultured human pulmonary arterial smooth muscle cells. Br J Pharmacol. 2005 Sep;146(1):49-59. The real-time RT-PCR analysis showed that the relative abundance of the encoding genes of I (A) alpha-subunit and K (V) channel-interacting proteins (KChIPs) was K (V) 4.2 > K (V) 3.4 > K (V) 4.3 (long) > K (V) 4.1, and KChIP3 >> KChIP2, respectively. I (A) was inhibited by 4-aminopyridine (4-AP) concentration-dependently, and could be separated pharmacologically into two components by tetraethylammonium (TEA) sensitivity. |
1(0,0,0,1) | Details |
| 20051248 | Jin H, Hadri L, Palomeque J, Morel C, Karakikes I, Kaprielian R, Hajjar R, Lebeche D: KChIP2 attenuates cardiac hypertrophy through regulation of I (to) and intracellular signaling. J Mol Cell Cardiol. 2010 Jan 4. Interestingly, blocking I (to) with 4-aminopyridine in KChIP2-overexpressing adult cardiomyocytes significantly increased the Ca (2+) transients to control levels. |
90(1,1,1,10) | Details |
| 19251214 | Thomsen MB, Sosunov EA, Anyukhovsky EP, Ozgen N, Boyden PA, Rosen MR: Deleting the accessory subunit KChIP2 results in loss of I (to,f) and increased I (K,slow) that maintains normal action potential configuration. Heart Rhythm. 2009 Mar;6(3):370-7. Epub 2008 Nov 27. RESULTS: Despite comparable baseline action potentials, APD was more markedly prolonged by 4-aminopyridine (4-AP) in KChIP2 (-/-) preparations. |
16(0,0,1,11) | Details |