| Name | voltage gated potassium channel |
|---|---|
| Synonyms | HERG; Voltage gated potassium channel; ERG; ERG1; Eag homolog; Eag related protein 1; Ether a go go related gene potassium channel 1; Ether a go go related protein 1… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17869444 | Yang Q, Chen SR, Li DP, Pan HL: Kv1.1/1.2 channels are downstream effectors of on synaptic release to preautonomic neurons in the paraventricular nucleus. Neuroscience. 2007 Oct 26;149(2):315-27. Epub 2007 Aug 8. Surprisingly, blocking of voltage-gated potassium channels (Kv) with 4-aminopyridine or alpha-dendrotoxin eliminated the effect of on mIPSCs in all labeled PVN neurons tested. |
81(1,1,1,1) | Details |
| 12740430 | Ridley JM, Milnes JT, Zhang YH, Witchel HJ, Hancox JC: Inhibition of HERG K+ current and prolongation of the guinea-pig ventricular action potential by 4-aminopyridine. J Physiol. 2003 Jun 15;549(Pt 3):667-72. Epub 2003 May 9. |
34(0,1,1,4) | Details |
| 19406003 | Alda JO, Valero MS, Pereboom D, Gros P, Garay RP: Endothelium-independent vasorelaxation by the selective alpha estrogen receptor agonist propyl pyrazole triol in rat aortic smooth muscle. J Pharm Pharmacol. 2009 May;61(5):641-6. KEY FINDINGS: PPT vasorelaxation was largely reduced by the selective ERalpha antagonist methyl-piperidinopyrazole (MPP; -91.6+/-2.5%), by the selective PKG inhibitor Rp-8-Br- (-78.6+/-4.9%), by the specific soluble guanylyl cyclase inhibitor ODQ (1H-(1,2,4)-oxadiazolo [4,3-a] quinoxalin-1-one; -85.3+/-5.2%) and to a lesser extent by the selective BKCa (large-conductance - and voltage-activated potassium channel) inhibitor iberiotoxin (-59.3%), the selective IKCa (intermediate-conductance -activated potassium channel) inhibitor TRAM-34 (1-[(2-chlorophenyl) diphenylmethyl]-1H-pyrazole; -50.7%) and the voltage-gated potassium channel inhibitor 4-aminopyridine (-40.8%). |
31(0,1,1,1) | Details |
| 17164473 | Ghatta S, Tunstall RR, Kareem S, Rahman M, O'Rourke ST: Sirolimus causes relaxation of human vascular smooth muscle: a novel action of sirolimus mediated via ATP-sensitive channels. J Pharmacol Exp Ther. 2007 Mar;320(3):1204-8. Epub 2006 Dec 12. In U46619-contracted rings, the response to sirolimus was markedly inhibited in the presence of the specific ATP-sensitive (K (ATP)) channel blocker, glyburide (10 (-6) M), but was unaffected by treatment with blockers of large conductance, -activated potassium channel (iberiotoxin, 10 (-7) M), small conductance, -activated potassium channel (apamin, 10 (-6) M), or voltage-gated potassium channel (4-aminopyridine, 10 (-3) M). |
31(0,1,1,1) | Details |
| 17893456 | Spohr F, Busch CJ, Reich C, Motsch J, Gebhard MM, Kuebler WM, Bloch KD, Weimann J: 4-Aminopyridine restores impaired hypoxic pulmonary vasoconstriction in endotoxemic mice. Anesthesiology. 2007 Oct;107(4):597-604. The aim of this study was to determine whether 4-aminopyridine (4-AP), a known voltage-gated potassium channel inhibitor, may restore HPV in sepsis. |
32(0,1,1,2) | Details |
| 12814842 | Galvan A, Smith Y, Wichmann T: Continuous monitoring of intracerebral levels in awake monkeys using microdialysis and enzyme fluorometric detection. J Neurosci Methods. 2003 Jun 30;126(2):175-85. levels were also increased when the microdialysis solution contained the blocker of voltage-gated potassium channels, 4-aminopyridine. |
6(0,0,1,1) | Details |
| 16707770 | Wareing M, Greenwood SL, Fyfe GK, Baker PN: Reactivity of human placental chorionic plate vessels from pregnancies complicated by intrauterine growth restriction (IUGR). Biol Reprod. 2006 Oct;75(4):518-23. Epub 2006 May 17. Experiments were also performed in the presence of 4-aminopyridine (4AP), a blocker of voltage-gated potassium channels. |
6(0,0,1,1) | Details |
| 15843617 | Weisz CJ, Raike RS, Soria-Jasso LE, Hess EJ: Potassium channel blockers inhibit the triggers of attacks in the calcium channel mouse mutant tottering. J Neurosci. 2005 Apr 20;25(16):4141-5. These mutations predict reduced currents, particularly in cerebellar Purkinje cells, where these channels are most abundant. 4-Aminopyridine (4-AP), a nonselective blocker of K (v) voltage-gated potassium channels, alleviates attacks of ataxia in EA2 patients. |
31(0,1,1,1) | Details |
| 20044444 | Gao L, Li Y, Schultz HD, Wang WZ, Wang W, Finch M, Smith LM, Zucker IH: Downregulated Kv4.3 expression in the RVLM as a potential mechanism for sympathoexcitation in rats with chronic heart failure. Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H945-55. Epub 2009 Dec 31. In intact animals, we found that microinjection of the voltage-gated potassium channel blocker, 4-aminopyridine, into the RVLM evoked a sympathoexcitation and hypertension in both normal and CHF rats. |
6(0,0,1,1) | Details |
| 18718350 | Strupp M, Kalla R, Glasauer S, Wagner J, Hufner K, Jahn K, Brandt T: Aminopyridines for the treatment of cerebellar and ocular motor disorders. Prog Brain Res. 2008;171:535-41. Animal experiments have shown that aminopyridines [3,4-diaminopyridine (3,4-DAP) and 4-aminopyridine (4-AP)], nonselective blockers of the Kv family of voltage-gated potassium channels, increase Purkinje-cell (PC) excitability. |
6(0,0,1,1) | Details |
| 19915712 | Renganathan M, Sidach S, Blight AR: Effects of 4-Aminopyridine on Cloned hERG Channels Expressed in Mammalian Cells. Arch Drug Inf. 2009 Sep;2(3):51-57. We evaluated the in vitro effects of 4-aminopyridine on the human ether-a-go-go-related gene (hERG) channel current, since hERG current inhibition is associated with QT interval prolongation-a precursor to torsade de pointes (TdP). |
31(0,1,1,1) | Details |
| 14526233 | Lindauer U, Vogt J, Schuh-Hofer S, Dreier JP, Dirnagl U: Cerebrovascular vasodilation to extraluminal acidosis occurs via combined activation of ATP-sensitive and Ca2+-activated channels. J Cereb Blood Flow Metab. 2003 Oct;23(10):1227-38. In separate experiments, ATP-sensitive channels (KATP) were blocked by extraluminal application of glibenclamide (Glib), Ca2+-activated channels (KCa) by tetraethylammonium (TEA), voltage-gated potassium channels (Kv) by 4-aminopyridine, and inward rectifier channels (KIR) by BaCl2. |
31(0,1,1,1) | Details |
| 18586426 | Matsushita S, Hyodo K, Imazuru T, Tokunaga C, Sato F, Enomoto Y, Hiramatsu Y, Sakakibara Y: The minimum coronary artery diameter in which coronary spasm can be identified by synchrotron radiation coronary angiography. Eur J Radiol. 2008 Dec;68(3 Suppl):S84-8. Epub 2008 Jun 30. Krebs-Henseleit solution (KH solution) was used as a perfusate. 10mM of 4-aminopyridine (4-AP: a voltage-gated potassium channel blocker; spasm inducer) was added to the KH solution and maintained for 5 min. |
6(0,0,1,1) | Details |
| 20357183 | Dou Y, Balse E, Dehghani Zadeh A, Wang T, Goonesekara CL, Noble GP, Eldstrom J, Steele DF, Hatem SN, Fedida D: Normal targeting of a tagged Kv1.5 channel acutely transfected into fresh adult cardiac myocytes by a biolistic method. Am J Physiol Cell Physiol. 2010 Mar 31. Here we apply the fast biolistic transfection procedure to adult cardiomyocytes to show that biolistically-introduced exogenous voltage-gated potassium channel, Kv1.5, is functional and, like endogenous Kv1.5, localizes to the intercalated disc, where it is expressed at the surface of that structure. Ventricular myocytes transfected with a tagged Kv1.5 exhibit an increased sustained current component that is ~40% sensitive to 100 muM 4-aminopyridine, and which is absent in myocytes transfected with a fluorescent protein-encoding construct alone. |
1(0,0,0,1) | Details |
| 16101738 | Pollock NS, Atkinson-Leadbeater K, Johnston J, Larouche M, Wildering WC, McFarlane S: Voltage-gated potassium channels regulate the response of retinal growth cones to axon extension and guidance cues. Eur J Neurosci. 2005 Aug;22(3):569-78. We showed previously that 4-aminopyridine and tetraethylammonium have different effects on the outward currents of embryonic Xenopus retinal ganglion cells. |
1(0,0,0,1) | Details |
| 16489642 | Li SY, Huang BB, Ouyang S: Effect of on voltage-gated potassium channels in guinea pig proximal colon smooth muscle cells. World J Gastroenterol. 2006 Jan 21;12(3):420-5. |
3(0,0,0,3) | Details |
| 17615948 | Lamarca V, Grasa L, Fagundes DS, Arruebo MP, Plaza MA, Murillo MD: K+ channels involved in contractility of rabbit small intestine. . J Physiol Biochem. 2006 Dec;62(4):227-36. These results suggest that both Ca2+-activated K+ channels of small and high conductance, and HERG K+ channels and inward rectifier K+ channels participate in spontaneous contractions of small intestine. It was found that 4-aminopyridine increased the tone of spontaneous contractions and reduced the amplitude and frequency of contractions. |
2(0,0,0,2) | Details |
| 15802557 | Mobasheri A, Gent TC, Womack MD, Carter SD, Clegg PD, Barrett-Jolley R: Quantitative analysis of voltage-gated currents from primary equine (Equus caballus) and elephant (Loxodonta africana) articular chondrocytes. Am J Physiol Regul Integr Comp Physiol. 2005 Jul;289(1):R172-80. Epub 2005 Mar 31. In this comparative study, we have established in vitro models of equine and elephant articular chondrocytes, examined their basic morphology, and characterized the biophysical properties of their primary voltage-gated potassium channel (Kv) currents. Pharmacological investigation of equine chondrocyte Kv currents showed them to be powerfully inhibited by the potassium channel blockers tetraethylammonium and 4-aminopyridine but not by dendrotoxin-I. |
2(0,0,0,2) | Details |
| 15262907 | Shokoji T, Fujisawa Y, Kimura S, Rahman M, Kiyomoto H, Matsubara K, Moriwaki K, Aki Y, Miyatake A, Kohno M, Abe Y, Nishiyama A: Effects of local administrations of tempol and diethyldithio-carbamic on peripheral nerve activity. Hypertension. 2004 Aug;44(2):236-43. Epub 2004 Jul 19. A voltage-gated potassium channel blocker, 4-aminopyridine (0.1 mol/L), significantly decreased basal RSNA (by -81+/-1%) and completely prevented DETC-induced increases in RSNA (n=5). |
7(0,0,1,2) | Details |
| 11907187 | Gupte SA, Li KX, Okada T, Sato K, Oka M: Inhibitors of pentose phosphate pathway cause vasodilation: involvement of voltage-gated potassium channels. J Pharmacol Exp Ther. 2002 Apr;301(1):299-305. Pretreatment of PA rings with tetraethylammonium or 4-aminopyridine caused rightward shifts of concentration-relaxation curves for 6-AN, EPI, and |
1(0,0,0,1) | Details |
| 10867867 | Kharkhun MI, Belevich AE, Povstian OV, Shuba MF: [The role of voltage-gated potassium channels in the formation of a resting membrane potential in the myocytes of rat resistive arteries]. Fiziol Zh. 2000;46(2):91-7. Transmembrane current had a 4 aminopyridine (4-AP) sensitive component of delayed rectifier current (KV). |
1(0,0,0,1) | Details |
| 18930118 | Su T, Cong WD, Long YS, Luo AH, Sun WW, Deng WY, Liao WP: Altered expression of voltage-gated potassium channel 4.2 and voltage-gated potassium channel 4-interacting protein, and changes in intracellular levels following lithium-pilocarpine-induced status epilepticus. Neuroscience. 2008 Dec 2;157(3):566-76. Epub 2008 Sep 27. We compared the difference in 4-aminopyridine (4-AP)-induced intracellular ([Ca (2+)] i) elevation between model and control brain slices. |
2(0,0,0,2) | Details |
| 10963252 | Michelakis E, Rebeyka I, Bateson J, Olley P, Puttagunta L, Archer S: Voltage-gated potassium channels in human ductus arteriosus. . Lancet. 2000 Jul 8;356(9224):134-7. |
2(0,0,0,2) | Details |
| 17289262 | Shen JF, Chao YL, Du L: Effects of static magnetic fields on the voltage-gated potassium channel currents in trigeminal root ganglion neurons. Neurosci Lett. 2007 Mar 26;415(2):164-8. Epub 2007 Jan 10. |
2(0,0,0,2) | Details |
| 12395204 | Bertaso F, Sharpe CC, Hendry BM, James AF: Expression of voltage-gated K+ channels in human atrium. Basic Res Cardiol. 2002 Nov;97(6):424-33. Both I (to1) and I (so) were inhibited by high concentrations (2 mM) of the K (+) channel blocker, 4-aminopyridine (4-AP). We used a semi-quantitative RT-PCR technique to examine the relative expression of mRNAs for the voltage-gated K (+) channel subunits, Kv1.2, Kv1.4, Kv1.5, Kv2.1, Kv4.2, Kv4.3, KvLQT1, HERG and IsK in samples of human atrial appendage. |
2(0,0,0,2) | Details |
| 11736694 | Imai T, Okamoto T, Yamamoto Y, Tanaka H, Koike K, Shigenobu K, Tanaka Y: Effects of different types of K+ channel modulators on the spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle. Acta Physiol Scand. 2001 Nov;173(3):323-33. A blocker of voltage-gated K+ (Kv) channel, 4-aminopyridine (100 microM), significantly increased contraction frequency. E-4031, a blocker of a novel inwardly rectifying K+ channel, i.e. the human ether-a-go-go-related gene (HERG) K+ channel, significantly increased contraction amplitude. |
2(0,0,0,2) | Details |
| 15357675 | Lew TS, Chang CS, Fang KP, Chen CY, Chen CH, Lin SC: The involvement of K (v) 3.4 voltage-gated potassium channel in the growth of an oral squamous cell carcinoma cell line. J Oral Pathol Med. 2004 Oct;33(9):543-9. This current pattern can be reversibly blocked by an A-type K (+) channel blocker 2 mM 4-aminopyridine (4-AP). |
1(0,0,0,1) | Details |
| 19584922 | Schaarschmidt G, Wegner F, Schwarz SC, Schmidt H, Schwarz J: Characterization of voltage-gated potassium channels in human neural progenitor cells. PLoS One. 2009 Jul 8;4(7):e6168. Both K (v) currents were differentially inhibited by selective neurotoxins like phrixotoxin-1 and alpha-dendrotoxin as well as by antagonists like 4-aminopyridine, ammoniumchloride, tetraethylammonium and quinidine. |
1(0,0,0,1) | Details |
| 18091358 | Thebaud B, Wu XC, Kajimoto H, Bonnet S, Hashimoto K, Michelakis ED, Archer SL: Developmental absence of the O2 sensitivity of L-type channels in preterm ductus arteriosus smooth muscle cells impairs O2 constriction contributing to patent ductus arteriosus. Pediatr Res. 2008 Feb;63(2):176-81. Impaired oxygen (O2)-induced vasoconstriction in preterm ductus arteriosus (DA) contributes to PDA and results, in part, from decreased function/expression of O2-sensitive, voltage-gated potassium channels (Kv) in DA smooth muscle cells (DASMCs). We show that preterm rabbit DA rings have reduced O2- and 4-aminopyridine (Kv blocker)-induced constriction. |
1(0,0,0,1) | Details |
| 11522604 | Soares AC, Duarte ID: Dibutyryl-cyclic GMP induces peripheral antinociception via activation of ATP-sensitive K (+) channels in the rat -induced hyperalgesic paw. Br J Pharmacol. 2001 Sep;134(1):127-31. Tetraethylammonium (2 mg paw (-1)), 4-aminopyridine (200 microg paw (-1)) and cesium (800 paw (-1)), non-selective voltage-gated potassium channel blockers, also had no effect. 6. |
0(0,0,0,0) | Details |
| 19592609 | Wu L, Rajamani S, Li H, January CT, Shryock JC, Belardinelli L: Reduction of repolarization reserve unmasks the proarrhythmic role of endogenous late Na (+) current in the heart. Am J Physiol Heart Circ Physiol. 2009 Sep;297(3):H1048-57. Epub 2009 Jul 10. To block I (K) and reduce repolarization reserve, E-4031, 4-aminopyridine, and BaCl (2) were used; to block endogenous late I (Na), tetrodotoxin (TTX) and ranolazine were used. |
0(0,0,0,0) | Details |
| 12084773 | Artym VV, Petty HR: Molecular proximity of Kv1.3 voltage-gated potassium channels and beta (1)-integrins on the plasma membrane of melanoma cells: effects of cell adherence and channel blockers. J Gen Physiol. 2002 Jul;120(1):29-37. Several K (+) channel blockers, including tetraethylammonium, 4-aminopyridine, and inhibited RET between beta1-integrins and Kv1.3 channels. |
2(0,0,0,2) | Details |
| 10634854 | Kang J, Huguenard JR, Prince DA: Voltage-gated potassium channels activated during action potentials in layer V neocortical pyramidal neurons. J Neurophysiol. 2000 Jan;83(1):70-80. |
2(0,0,0,2) | Details |
| 17980032 | Smith RC, McClure MC, Smith MA, Abel PW, Bradley ME: The role of voltage-gated potassium channels in the regulation of mouse uterine contractility. Reprod Biol Endocrinol. 2007 Nov 2;5:41. RESULTS: The Kv channel blocker 4-aminopyridine (4-AP) caused contractions in nonpregnant mouse myometrium (EC50 = 54 micromolar, maximal effect at 300 micromolar) but this effect disappeared in pregnant mice; similarly, the Kv4.2/Kv4.3 blocker phrixotoxin-2 caused contractions in nonpregnant, but not pregnant, myometrium. |
1(0,0,0,1) | Details |
| 15738276 | Bekar LK, Loewen ME, Cao K, Sun X, Leis J, Wang R, Forsyth GW, Walz W: Complex expression and localization of inactivating Kv channels in cultured hippocampal astrocytes. J Neurophysiol. 2005 Mar;93(3):1699-709. Voltage-gated potassium channels are well established as critical for setting action potential frequency, membrane potential, and neurotransmitter release in neurons. |
1(0,0,0,1) | Details |
| 15610163 | Brooke RE, Moores TS, Morris NP, Parson SH, Deuchars J: Kv3 voltage-gated potassium channels regulate neurotransmitter release from mouse motor nerve terminals. Eur J Neurosci. 2004 Dec;20(12):3313-21. Consistent with this, 15-microM 4-aminopyridine, which blocks Kv3 but not large-conductance -activated channels, enhanced evoked EPP amplitude. |
1(0,0,0,1) | Details |
| 11521164 | Sampson LJ, Plane F, Garland CJ: Involvement of cyclic GMP and channels in relaxation evoked by the donor, diethylamine in the rat small isolated mesenteric artery. Naunyn Schmiedebergs Arch Pharmacol. 2001 Sep;364(3):220-5. The selective inhibitor of BK (Ca) channels, iberiotoxin (IbTX; 30 nM), and 4-aminopyridine (4-AP; 1 mM), an inhibitor of voltage-gated potassium channels (Kv), failed to modify DEA -evoked relaxation. |
0(0,0,0,0) | Details |
| 12168055 | Abdul M, Hoosein N: Voltage-gated potassium ion channels in colon cancer. . Oncol Rep. 2002 Sep-Oct;9(5):961-4. Voltage-gated potassium channels (VGPCs) have been previously implicated in cellular proliferation. PC-blockers such as glibenclamide inhibited cellular proliferation at concentrations above 50 microg/ml while tetraethylammonium and 4-aminopyridine (up to 100 microg/ml) did not have significant growth-suppressive effects. |
1(0,0,0,1) | Details |
| 11750932 | Nashmi R, Fehlings MG: Mechanisms of axonal dysfunction after spinal cord injury: with an emphasis on the role of voltage-gated potassium channels. Brain Res Brain Res Rev. 2001 Dec;38(1-2):165-91. This theory and electrophysiological studies using K+ channel blockers on animal nerve preparations prompted the investigation of 4-aminopyridine (4-AP), a blocker of rapidly activating voltage-gated K+ channels, as a therapeutic agent in both multiple sclerosis and spinal cord injured patients. |
1(0,0,0,1) | Details |
| 11877512 | Devaux J, Gola M, Jacquet G, Crest M: Effects of K+ channel blockers on developing rat myelinated CNS axons: identification of four types of K+ channels. J Neurophysiol. 2002 Mar;87(3):1376-85. Four blockers of voltage-gated potassium channels (Kv channels) were tested on the compound action potentials (CAPs) of rat optic nerves in an attempt to determine the regulation of Kv channel expression during the process of myelination. Before myelination occurred, 4-aminopyridine (4-AP) increased the amplitude, duration, and refractory period of the CAPs. |
1(0,0,0,1) | Details |
| 17982020 | Telezhkin V, Goecks T, Bonev AD, Osol G, Gokina NI: Decreased function of voltage-gated potassium channels contributes to augmented myogenic tone of uterine arteries in late pregnancy. Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H272-84. Epub 2007 Nov 2. Exposure of vessels from NP animals to 4-aminopyridine, which inhibits the activity of K (v) channels, mimicked the effects of pregnancy by increasing pressure-induced depolarization, elevation of [Ca (2+)](i), and development of myogenic tone. |
1(0,0,0,1) | Details |
| 19268479 | Han WQ, Zhu DL, Wu LY, Chen QZ, Guo SJ, Gao PJ: -induced vasodilation involves voltage-gated potassium channels in rat aorta. Life Sci. 2009 May 22;84(21-22):732-7. Epub 2009 Mar 4. NAC-induced vasodilation was significantly reduced in the presence of voltage-gated K+ channels (Kv) inhibitor 4-aminopyridine (4-AP). |
1(0,0,0,1) | Details |
| 10648707 | McFarlane S, Pollock NS: A role for voltage-gated potassium channels in the outgrowth of retinal axons in the developing visual system. J Neurosci. 2000 Feb 1;20(3):1020-9. Second, a Kv channel blocker, 4-aminopyridine (4-AP), was applied to the developing Xenopus optic projection. |
1(0,0,0,1) | Details |
| 11481235 | Archer SL, London B, Hampl V, Wu X, Nsair A, Puttagunta L, Hashimoto K, Waite RE, Michelakis ED: Impairment of hypoxic pulmonary vasoconstriction in mice lacking the voltage-gated potassium channel Kv1.5. FASEB J. 2001 Aug;15(10):1801-3. |
1(0,0,0,1) | Details |
| 12740033 | Li Y, Ganta S, von Stein FB, Mason DE, Mitchell BM, Freeman LC: 4-aminopyridine decreases production by porcine granulosa cells. Reprod Biol Endocrinol. 2003 Apr 1;1:31. Granulosa cells have been shown to express voltage-gated potassium channels from more than one family. |
1(0,0,0,1) | Details |
| 19542906 | Konduri GG, Bakhutashvili I, Eis A, Gauthier KM: Impaired voltage gated potassium channel responses in a fetal lamb model of persistent pulmonary hypertension of the newborn. Pediatr Res. 2009 Sep;66(3):289-94. We studied changes in the tone of pulmonary artery (PA) rings and Kv channel current of freshly isolated PA smooth muscle cells (PASMC) using standard techniques. 4-Aminopyridine (4-AP), a Kv channel antagonist, induced dose-dependent constriction of control PA rings; this response was attenuated in PPHN pulmonary arteries. |
1(0,0,0,1) | Details |
| 14632936 | Chang KW, Yuan TC, Fang KP, Yang FS, Liu CJ, Chang CS, Lin SC: The increase of voltage-gated potassium channel Kv3.4 mRNA expression in oral squamous cell carcinoma. J Oral Pathol Med. 2003 Nov;32(10):606-11. In addition, administration of an A-type K+ channel blocker, 4-aminopyridine (4-AP), and an antisense oligodeoxynucleotide (ODN) directed specifically against Kv3.4 were performed to identify the involvement of Kv3.4 in the growth of OSCC cells. |
1(0,0,0,1) | Details |
| 18836167 | Yu YC, Satoh H, Wu SM, Marshak DW: enhances voltage-gated currents of ON bipolar cells in macaque retina. Invest Ophthalmol Vis Sci. 2009 Feb;50(2):959-65. Epub 2008 Oct 3. Voltage-gated potassium channels have also been localized to bipolar cell dendrites, and the hypothesis tested in the present study was that these are modulated by the HR3 agonist (R) alpha- (RAMH), tetraethyl ammonium (TEA), and 4-aminopyridine (4-AP) were applied in the superfusate. |
1(0,0,0,1) | Details |
| 16051887 | Choi WS, Khurana A, Mathur R, Viswanathan V, Steele DF, Fedida D: Kv1.5 surface expression is modulated by retrograde trafficking of newly endocytosed channels by the dynein motor. Circ Res. 2005 Aug 19;97(4):363-71. Epub 2005 Jul 28. In this article we have investigated the mechanisms by which retrograde trafficking regulates the surface expression of the voltage-gated potassium channel, Kv1.5. |
1(0,0,0,1) | Details |
| 11922912 | Bonnet S, Dubuis E, Vandier C, Martin S, Marthan R, Savineau JP: Reversal of chronic hypoxia-induced alterations in pulmonary artery smooth muscle electromechanical coupling upon air breathing. Cardiovasc Res. 2002 Mar;53(4):1019-28. PAMCs from CH rats were depolarised (about 20 mV), had an elevated concentration and exhibited a hypersensitivity to 4-aminopyridine (4-AP) of membrane potential as well as the tone of arterial rings compared with tissues from control rats. Whole cell patch-clamp recordings indicated that voltage gated potassium channel currents I (Kv) and I (K (N)) were decreased in PAMCs from CH rats with a hyper sensitivity of I (K (N)) to 4-AP. |
1(0,0,0,1) | Details |
| 16601321 | Teisseyre A, Mozrzymas JW: Influence of extracellular pH on the modulatory effect of zinc ions on Kv1.3 channels. J Physiol Pharmacol. 2006 Mar;57(1):131-47. In the present study we applied the whole-cell patch-clamp technique to study the influence of extracellular pH (pH (o)) on the modulatory effect exerted by zinc ions (Zn (2+)) on voltage-gated potassium channels Kv1.3 expressed in human lymphocytes. |
1(0,0,0,1) | Details |
| 11517244 | Bekkers JM, Delaney AJ: Modulation of excitability by alpha-dendrotoxin-sensitive channels in neocortical pyramidal neurons. J Neurosci. 2001 Sep 1;21(17):6553-60. Voltage-gated potassium channels, being numerous and diverse constituents of neuronal membrane, are important participants in neuronal excitability and thus in synaptic integration. Low concentrations of 4-aminopyridine or alpha-dendrotoxin (alpha-DTX) dramatically increased excitability: the firing threshold for action potentials was hyperpolarized by 4-8 mV, and the firing frequency during a 1-sec-long 500 pA somatic current step was doubled. |
1(0,0,0,1) | Details |