| 17289262 |
Shen JF, Chao YL, Du L: Effects of static magnetic fields on the voltage-gated potassium channel currents in trigeminal root ganglion neurons. Neurosci Lett. 2007 Mar 26;415(2):164-8. Epub 2007 Jan 10.
To evaluated the effects of moderate-intensity static magnetic fields (SMF) on two types of voltage-gated potassium channel (VGPC) currents: I (K,A) and I (K,V), whole-cell patch-clamp experiments were conducted on acute dissociated rat trigeminal root ganglion (TRG) neurons. The results demonstrated that 125 mT SMF could influence the inactivation kinetics of these two VGPC currents by altering the inactivation rate and velocity. No significant change was observed in the activation properties. These findings supported the hypothesis that biological membrane would be deformed in moderate-intensity SMF and the physiological characteristics of ion channels on the membrane would be influenced. The mechanism underlying the different effects of SMF on the I (K,A) and I (K,V) inactivation was also discussed. |
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