| Name | cholinesterase |
|---|---|
| Synonyms | Acylcholine acylhydrolase; BCHE; BCHE protein; Butyrylcholine esterase; Butyrylcholinesterase; CHE1; Choline esterase II; Cholinesterase… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18023348 | Scipione L, De Vita D, Musella A, Flammini L, Bertoni S, Barocelli E: 4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity. Bioorg Med Chem Lett. 2008 Jan 1;18(1):309-12. Epub 2007 Nov 19. |
163(2,2,2,3) | Details |
| 11256231 | Ogura H, Kosasa T, Kuriya Y, Yamanishi Y: Comparison of inhibitory activities of and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol. 2000 Oct;22(8):609-13. The derivatives showed moderate selectivity, while the 4-aminopyridine derivatives tacrine and ipidacrine showed no selectivity. |
4(0,0,0,4) | Details |
| 19540221 | Munhoz E, De Lima TC, Souccar C, Lapa AJ, Lima-Landman MT: Allosteric interaction of the anticholinergic drug [N-(4-phenyl)-phenacyl-l-hyoscyamine] (Phenthonium) with nicotinic receptors of post-ganglionic sympathetic neurons of the rat vas deferens. Eur J Pharmacol. 2009 Aug 15;616(1-3):229-35. Epub 2009 Jun 18. Specifically, Phenthonium increases the spontaneous release of at the motor endplate without depolarizing the muscle or inhibiting cholinesterase activity. Twitch depression did not occur after K (+)-channel blockade with 4-aminopyridine (4-AP) or charybdotoxin. |
1(0,0,0,1) | Details |
| 15031302 | Harrison PK, Sheridan RD, Green AC, Scott IR, Tattersall JE: A guinea pig hippocampal slice model of organophosphate-induced seizure activity. J Pharmacol Exp Ther. 2004 Aug;310(2):678-86. Epub 2004 Mar 18. Extracellular recording techniques have been used in the guinea pig hippocampal slice preparation to investigate the electrophysiological actions of the organophosphate (OP) anticholinesterase soman. In contrast to soman-induced epileptiform activity, bursting induced by the K (+) channel blocker 4-aminopyridine (30 microM), the adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (30 nM) or perfusion with low Mg (2+) buffer was insensitive to atropine (10 microM). |
1(0,0,0,1) | Details |