| Name | P13 |
|---|---|
| Synonyms | 3' 5' exoribonuclease CSL4 homolog; 3' 5' exoribonuclease CSL4 homolog; CGI 108; CGI108; CSL 4; CSL4; Csl4p; EXOSC 1… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11412897 | Wong M, Yamada KA: Developmental characteristics of epileptiform activity in immature rat neocortex: a comparison of four in vitro seizure models. Brain Res Dev Brain Res. 2001 Jun 29;128(2):113-20. The present study investigated developmental changes in epileptiform activity in rat neocortical slices from four age groups (postnatal days P4--7, P13--16, P23--26, P41--47) due to four pharmacological conditions (4-aminopyridine, low picrotoxin, CGP-35348) that differentially modulate and systems. |
37(0,1,2,2) | Details |
| 18394864 | Zhu L, Polley N, Mathews GC, Delpire E: NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus. . Epilepsy Res. 2008 May;79(2-3):201-12. Epub 2008 Apr 3. Here we show that absence of NKCC1 in P9-P13 CA3 pyramidal neurons, through genetic manipulation or through bumetanide inhibition, results in a significant increase in cell excitability. Furthermore, the pro-convulsant agent 4-aminopyridine induces seizure-like events in NKCC1-null mice but not in wild-type mice. |
3(0,0,0,3) | Details |
| 16822247 | Gajda Z, Hermesz E, Gyengesi E, Szupera Z, Szente M: The functional significance of gap junction channels in the epileptogenicity and seizure susceptibility of juvenile rats. Epilepsia. 2006 Jun;47(6):1009-22. A transient decrease (P13-14) and then increase (P15-16) in seizure susceptibility were followed by a tendency to periodicity and focalization. PURPOSE: The functional significance of gap-junction (GJ) channels in seizure susceptibility and induction and maintenance of seizures in the developing rat brain was investigated on the 4-aminopyridine (4-AP) in vivo epilepsy model. |
1(0,0,0,1) | Details |
| 18234240 | Pedroarena CM, Kamphausen S: Glycinergic synaptic currents in the deep cerebellar nuclei. . Neuropharmacology. 2008 Apr;54(5):784-95. Epub 2007 Dec 23. Spontaneous glycinergic IPSCs were very rare but direct presynaptic depolarization by superfusion with elevated concentration or application of 4-aminopyridine consistently evoked strychnine sensitive IPSCs. |
0(0,0,0,0) | Details |