| Name | phospholipase C |
|---|---|
| Synonyms | PLC L; PLCE; PLC L (PLC epsilon); PLCL; PLCL 1; PLCL1; PLDL 1; PLDL1… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12694813 | Berg T: The vascular response to the K+ channel inhibitor 4-aminopyridine in hypertensive rats. Eur J Pharmacol. 2003 Apr 18;466(3):301-10. These results indicated an increased catecholamine, angiotensin AT (1) and endothelin ET (A) activation of the phospholipase C-protein kinase C pathway in SHR, inhibiting the 4-aminopyridine-sensitive K+ channels. |
81(1,1,1,1) | Details |
| 17402970 | Wang M, Bianchi R, Chuang SC, Zhao W, Wong RK: Group I metabotropic glutamate receptor-dependent TRPC channel trafficking in hippocampal neurons. J Neurochem. 2007 Apr;101(2):411-21. Translocation of TRPC4 and TRPC5 was also prevented in slices from phospholipase C (PLC) beta1 knockout mice, even when synchronized discharges were elicited by the convulsant 4-aminopyridine. |
6(0,0,1,1) | Details |
| 12065624 | Donald AN, Wallace DJ, McKenzie S, Marley PD: Phospholipase C-mediated signalling is not required for -induced catecholamine secretion from bovine chromaffin cells. J Neurochem. 2002 Jun;81(5):1116-29. A possible role for signalling through phospholipase C in -induced catecholamine secretion from bovine chromaffin cells has been investigated. Blocking various K (+) channels with apamin, charybdotoxin, Ba (2+), tetraethylammonium, 4-aminopyridine, tertiapin or glibenclamide failed to reduce the ability of to evoke secretion. |
3(0,0,0,3) | Details |
| 14585815 | Mhaouty-Kodja S, Houdeau E, Legrand C: Regulation of myometrial phospholipase C system and uterine contraction by beta-adrenergic receptors in midpregnant rat. Biol Reprod. 2004 Mar;70(3):570-6. Epub 2003 Oct 29. In contrast, two global (K+) channel inhibitors, tetraethylammonium (TEA) and 4-aminopyridine (4-AP), prevented attenuation of InsP production by isoproterenol. |
2(0,0,0,2) | Details |
| 17016851 | Wang SJ, Wang KY, Wang WC, Sihra TS: Unexpected inhibitory regulation of release from rat cerebrocortical nerve terminals by presynaptic 5-hydroxytryptamine-2A receptors. J Neurosci Res. 2006 Nov 15;84(7):1528-42. DOI potently inhibited 4-aminopyridine (4AP)-evoked release. Mechanistically, DOI modulation of 4AP-evoked release appeared to involve a phospholipase C/protein kinase C signaling cascade, insofar as pretreatment of synaptosomes with the phospholipase C inhibitor U73122 or protein kinase C inhibitors Ro320432 or GF109203X all effectively occluded the inhibitory effect of the agonist. |
2(0,0,0,2) | Details |
| 19931239 | Dwyer L, Kim HJ, Koh BH, Koh SD: Phospholipase C-independent effects of 3M3FBS in murine colon. . Eur J Pharmacol. 2010 Feb 25;628(1-3):187-94. Epub 2009 Nov 18. Both m-3M3FBS and o-3M3FBS decreased two components of delayed rectifier K (+) currents in the presence of tetraethylammonium or 4-aminopyridine. |
2(0,0,0,2) | Details |
| 12629172 | Gebremedhin D, Yamaura K, Zhang C, Bylund J, Koehler RC, Harder DR: Metabotropic glutamate receptor activation enhances the activities of two types of Ca2+-activated k+ channels in rat hippocampal astrocytes. J Neurosci. 2003 Mar 1;23(5):1678-87. Patch-clamp analysis of K (+) channel currents in cultured astrocytes identified the existence of 71 +/- 6 and 161 +/- 11 pS single-channel K (+) currents that were sensitive to changes in voltage and [Ca (2+)](i) and blocked by external TEA but not by charybdotoxin, iberiotoxin, apamin, or 4-aminopyridine. Activation of the two types of K (+) channel currents by mGluR agonists was attenuated by pertussis toxin and by inhibition of phospholipase C (PLC) or cytochrome P450 epoxygenase. |
1(0,0,0,1) | Details |
| 16258525 | Serir K, Hayoz S, Fanchaouy M, Beny JL, Bychkov R: A delayed ATP-elicited K+ current in freshly isolated smooth muscle cells from mouse aorta. Br J Pharmacol. 2006 Jan;147(1):45-54. A phospholipase C inhibitor, U73122 (1 microM), was shown to abolish the delayed ATP-elicited response. The known K (+)-channel blockers, iberiotoxin, charybdotoxin, glibenclamide, apamin, 4-aminopyridine, Ba (2+) and tetraethylammonium all failed to inhibit the delayed ATP-elicited K (+) current. |
1(0,0,0,1) | Details |
| 12364493 | Lee AC, Wong RK, Chuang SC, Shin HS, Bianchi R: Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slices. J Neurophysiol. 2002 Oct;88(4):1625-33. Addition of 4-aminopyridine (4-AP; 100 microM) prolonged these bursts to 0.7-2 s. In phospholipase C beta1 (PLCbeta1) knockout mice, bicuculline and 4-AP elicited prolonged synchronized discharges of comparable duration as those observed in slices from wild-type littermates. |
1(0,0,0,1) | Details |
| 16019148 | Han P, Lucero MT: Pituitary adenylate cyclase activating polypeptide reduces A-type K+ currents and caspase activity in cultured adult mouse olfactory neurons. Neuroscience. 2005;134(3):745-56. Interestingly, we found that the protective effects of pituitary adenylate cyclase activating polypeptide were related to the absence of a 4-aminopyridine (IC50=144 microM) sensitive rapidly inactivating current often referred to as A-type current. |
0(0,0,0,0) | Details |
| 14623765 | White AM, Kylanpaa RA, Christie LA, McIntosh SJ, Irving AJ, Platt B: Presynaptic group I metabotropic glutamate receptors modulate synaptic transmission in the rat superior colliculus via 4-AP sensitive K (+) channels. Br J Pharmacol. 2003 Dec;140(8):1421-33. Epub 2003 Nov 17. The K+ channel antagonist 4-aminopyridine (4-AP, 50-100 microm) converted the inhibitory effect of into facilitation. |
0(0,0,0,0) | Details |