Protein Information

Name c Jun N terminal kinase (protein family or complex)
Synonyms c Jun N terminal kinase; JNK; c Jun NH (2) terminal kinase; Jun N terminal kinase

Compound Information

Name 4-aminopyridine
CAS 4-pyridinamine

Reference List

PubMed Abstract RScore(About this table)
17055723 Liu G, Zhao H, Liu B, Xin Z, Liu M, Serby MD, Lubbers NL, Widomski DL, Polakowski JS, Beno DW, Trevillyan JM, Sham HL: Hemodynamic effects of potent and selective JNK inhibitors in anesthetized rats: implication for targeting protein kinases in metabolic diseases. Bioorg Med Chem Lett. 2007 Jan 15;17(2):495-500. Epub 2006 Oct 10.

The hemodynamic effects of a series of potent and selective 4-aminopyridine carboxamide-based pan-JNK inhibitors were assessed in an anesthetized rat model.
32(0,1,1,2) Details
17397832 Pan Z, Capo-Aponte JE, Zhang F, Wang Z, Pokorny KS, Reinach PS: Differential dependence of regulatory volume decrease behavior in rabbit corneal epithelial cells on MAPK superfamily activation. Exp Eye Res. 2007 May;84(5):978-90. Epub 2007 Feb 11.

Similar declines occurred with either a high-K+ (20 mM) supplemented solution or the K+ channel inhibitor 4-aminopyridine.
Activation of extracellular signal-regulated kinase (ERK), p38, and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) was time and tonicity-dependent.
1(0,0,0,1) Details
15086522 Merlo D, Cifelli P, Cicconi S, Tancredi V, Avoli M: 4-Aminopyridine-induced epileptogenesis depends on activation of mitogen-activated protein kinase ERK. J Neurochem. 2004 May;89(3):654-9.

0(0,0,0,0) Details