| Name | AP 3 (protein family or complex) |
|---|---|
| Synonyms | AP 3 adapter complex; AP 3; AP 3 complex; Adapter related protein complex 3 |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18251723 | Clemente CM, Araujo PV, Palheta RC Jr, Ratts ZM, Fernandes GH, Rola FH, de Oliveira RB, dos Santos AA, Magalhaes PJ: inhibits duodenal contractility via activation of the NO-K+ channel pathway. Fundam Clin Pharmacol. 2008 Feb;22(1):61-7. In isolated strips pretreated with BaCl (2) (0.2 mM), 4-aminopyridine (4-AP, 3 mM), or glybenclamide (1 microM), the -induced EC (50) value was significantly increased to 32.8 (19.1-56.4), 27.1 (15.2-48.3) and 20.1 (16.4-24.7) microM, respectively. |
6(0,0,1,1) | Details |
| 11022080 | Quan L, Sobey CG: Selective effects of subarachnoid hemorrhage on cerebral vascular responses to 4-aminopyridine in rats. Stroke. 2000 Oct;31(10):2460-5. Vascular responses to 4-aminopyridine (4-AP), 3-aminopyridine (3-AP), tetraethylammonium (TEA), and were compared in control and SAH rats. |
6(0,0,1,1) | Details |
| 19923250 | Sun W, Smith D, Fu Y, Cheng JX, Bryn S, Borgens R, Shi R: Novel potassium channel blocker, 4-AP-3-MeOH, inhibits fast channels and restores axonal conduction in injured guinea pig spinal cord white matter. J Neurophysiol. 2010 Jan;103(1):469-78. Epub 2009 Nov 18. We have demonstrated that 4-aminopyridine-3- (4-AP-3-MeOH), a 4-aminopyridine derivative, significantly restores axonal conduction in stretched spinal cord white-matter strips and shows no preference in restoring large and small axons. |
4(0,0,0,4) | Details |
| 11999672 | Nakajima I, Watanabe H, Iino K, Saito T, Miura M: Ca2+ overload evokes a transient outward current in guinea-pig ventricular myocytes. Circ J. 2002 Jan;66(1):87-92. There are 2 types of transient outward currents (Ito) in the hearts of various mammals: a 4-aminopyridine (4-AP) sensitive K+ current and a 4-AP resistant Ca2+ activated current, carried by Cl-, (referred to as I (to1) and I (to2), respectively). This I (to) was resistant to 4-AP (3 mmol/L, n=30) but sensitive to both anthrancene-9-carboxylic acid (9-AC, 3 mmol/L, n=8) and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (100 micromol/L, n=3). |
1(0,0,0,1) | Details |
| 11152736 | Zhang YH, Kenyon JL, Nicol GD: Phorbol ester-induced inhibition of currents in rat sensory neurons requires voltage-dependent entry of J Neurophysiol. 2001 Jan;85(1):362-73. The potassium channel blockers tetraethylammonium (TEA, 10 mM) and 4-aminopyridine (4-AP, 3 mM and 30 microM) reduced I (K), but only TEA attenuated the ability of PDBu to further inhibit the current, suggesting that the I (K) modified by PDBu was sensitive to TEA. |
31(0,1,1,1) | Details |
| 11861330 | Andreasen M: Inhibition of slow Ca (2+)-activated K (+) current by 4-aminopyridine in rat hippocampal CA1 pyramidal neurones. Br J Pharmacol. 2002 Feb;135(4):1013-25. The reduction was evident at submillimolar concentration and increased to about 80% with 4 mM 4-AP. 3. |
1(0,0,0,1) | Details |
| 12815611 | Moretto MB, Rossato JI, Nogueira CW, Zeni G, Rocha JB: Voltage-dependent ebselen and diorganochalcogenides inhibition of 45Ca2+ influx into brain synaptosomes. J Biochem Mol Toxicol. 2003;17(3):154-60. In the present investigation, changes in Ca (2+) influx into synaptosomes by organic forms of and tellurium were examined under nondepolarizing and depolarizing conditions induced by high KCl concentration (135 mM) or by 4-aminopyridine (4-AP). In the presence of 4-AP (3 mM) as depolarizing agent, ebselen (400 micro M) caused a significant increase, whereas diphenyl diselenide and diphenyl ditelluride inhibited Ca (2+) influx into synaptosomes. |
1(0,0,0,1) | Details |
| 12667949 | Li GR, Du XL, Siow YL, O K, Tse HF, Lau CP: -activated transient outward current and phase 1 repolarization of swine ventricular action potential. Cardiovasc Res. 2003 Apr 1;58(1):89-98. OBJECTIVE: It is unknown whether 4-aminopyridine- (4-AP-) sensitive transient outward K (+) current (I (to1)) and/or Ca (2+)-activated transient outward Cl (-) current (I (Ca.Cl) or I (to2)) contribute (s) to phase 1 repolarization of pig ventricular action potential (AP). |
0(0,0,0,0) | Details |
| 17435380 | Matsushita M, Tanaka Y, Koike K: Studies on the mechanisms underlying beta-adrenoceptor-mediated relaxation of rat abdominal aorta. J Smooth Muscle Res. 2006 Dec;42(6):217-25. Isoprenaline-induced relaxation in the presence of SQ 22,536 was significantly diminished by iberiotoxin (IbTx, 0.1 microM), but was not affected by 4-aminopyridine (4-AP, 3 mM). |
0(0,0,0,0) | Details |