| Name | c kit |
|---|---|
| Synonyms | C Kit; CD117; CD117 antigen; KIT; KIT oncogene Mast cell growth factor receptor; KIT protein; Mast/stem cell growth factor receptor; Mast/stem cell growth factor receptor precursor… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20130208 | Han Y, Chen JD, Liu ZM, Zhou Y, Xia JH, Du X, Jin MW: Functional ion channels in mouse cardiac c-kit+ cells. Am J Physiol Cell Physiol. 2010 Feb 3. It was found that three types of ionic currents were present in mouse cardiac c-kit (+) cells, including a delayed rectifier K (+) current (IK (DR)) inhibited by 4-aminopyridine (4-AP), an inward rectifier K (+) current (I (Kir)) decreased by Ba (2+), and a volume-sensitive current (I (Cl.vol)) inhibited by 5-nitro-1-(3-phenylpropylamino) (NPPB). |
85(1,1,1,5) | Details |
| 11389194 | Hatton WJ, Mason HS, Carl A, Doherty P, Latten MJ, Kenyon JL, Sanders KM, Horowitz B: Functional and molecular expression of a voltage-dependent K (+) channel (Kv1.1) in interstitial cells of Cajal. J Physiol. 2001 Jun 1;533(Pt 2):315-27. The remaining, DTX-insensitive current (i.e. current in the presence of 10 (-8) M DTX-K) was outwardly rectifying, rapidly activating, non-inactivating during 500 ms step depolarizations, and could be blocked by both tetraethylammonium (TEA) and 4-aminopyridine (4-AP). 5. Immunohistochemical co-localization of Kv1.1 with c-kit (a specific marker for ICC) and vimentin (a specific marker of neurons and ICC) indicated that Kv1.1-like immunoreactivity (Kv1.1-LI) was present in ICC and neurons of GI tissues of the dog, guinea-pig and mouse. |
1(0,0,0,1) | Details |
| 12897177 | Pucovsky V, Moss RF, Bolton TB: Non-contractile cells with thin processes resembling interstitial cells of Cajal found in the wall of guinea-pig mesenteric arteries. J Physiol. 2003 Oct 1;552(Pt 1):119-33. Epub 2003 Aug 1. Voltage clamp of single AIL cells revealed an inward current that was four times more dense than in myocytes and was abolished by 10 microM nicardipine, and an outward current carried exclusively by ions that was reduced by 1 mM 4-aminopyridine and/or 100 nM iberiotoxin but unaffected by 10 nM dendrotoxin-K. |
0(0,0,0,0) | Details |
| 17382781 | Lang RJ, Zoltkowski BZ, Hammer JM, Meeker WF, Wendt I: Electrical characterization of interstitial cells of Cajal-like cells and smooth muscle cells isolated from the mouse ureteropelvic junction. J Urol. 2007 Apr;177(4):1573-80. MATERIALS AND METHODS: Interstitial cells of Cajal-like cells were identified using c-Kit antibodies and fresh whole mount preparations of ureteropelvic junction. RESULTS: Membrane depolarization of single smooth muscle cells evoked a complex K (+) selective outward current consisting of a rapidly activating 4-aminopyridine sensitive transient outward current, followed by a more slowly developing outward current that was decreased by blockers of large conductance Ca (2+) activated K (+) channels. |
2(0,0,0,2) | Details |