| Name | glycine receptors (protein family or complex) |
|---|---|
| Synonyms | Glycine receptor; Glycine receptors |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12213259 | Wong JY, Ross SA, McColl C, Massalas JS, Powney E, Finkelstein DI, Clark M, Horne MK, Berkovic SF, Drago J: Proconvulsant-induced seizures in alpha (4) nicotinic acetylcholine receptor subunit knockout mice. Neuropharmacology. 2002 Jul;43(1):55-64. We investigated the response of alpha (4) nAChR subunit knockout mice to the (GABA) receptor antagonists; pentylenetetrazole (PTZ) and bicuculline (BIC), the glutamate receptor agonist kainic acid (KA), the glycine receptor antagonist strychnine and the K (+) channel blocker 4-aminopyridine (4-AP). |
31(0,1,1,1) | Details |
| 16262635 | Ruscheweyh R, Sandkuhler J: Long-range oscillatory Ca2+ waves in rat spinal dorsal horn. Eur J Neurosci. 2005 Oct;22(8):1967-76. However, increasing neuronal excitability by application of 4-aminopyridine after pretreatment of the slice with blockers of (RS)-alpha-amino-3--5-methyl-4-isoxazolepropionic acid (AMPA)/kainate, (GABA)(A) and glycine receptors evoked repetitive Ca2+ waves in dorsal horn. |
7(0,0,1,2) | Details |
| 19359371 | Chapman RJ, Cilia La Corte PF, Asghar AU, King AE: Network-based activity induced by 4-aminopyridine in rat dorsal horn in vitro is mediated by both chemical and electrical synapses. J Physiol. 2009 Jun 1;587(Pt 11):2499-510. Epub 2009 Apr 9. The glycine receptor antagonist strychnine (4 microM) and the (A) receptor antagonist bicuculline (10 microM) diminished and abolished, respectively, field population spiking and both antagonists reduced the power of 4-12 Hz oscillations. |
1(0,0,0,1) | Details |
| 16289841 | Taccola G, Nistri A: Fictive locomotor patterns generated by tetraethylammonium application to the neonatal rat spinal cord in vitro. Neuroscience. 2006;137(2):659-70. Epub 2005 Nov 14. Rhythmic alternating patterns elicited by tetraethylammonium on ventral roots were relatively stereotypic, had limited synergy with fictive locomotion induced by dorsal root stimuli, and were not accelerated by 4-aminopyridine. Rhythmic alternating patterns were suppressed by blockers of (A) and glycine receptors, disclosing a background of depolarizing bursts inhibited by antagonism of group I metabotropic glutamate receptors. |
1(0,0,0,1) | Details |
| 17604007 | Eto K, Arimura Y, Nabekura J, Noda M, Ishibashi H: The effect of zinc on glycinergic inhibitory postsynaptic currents in rat spinal dorsal horn neurons. Brain Res. 2007 Aug 3;1161:11-20. Epub 2007 Jun 12. These results suggest that, in addition to an action on the postsynaptic glycine receptors, zinc may depolarize the presynaptic nerve terminals, leading to an activation of voltage-dependent Na (+) and Ca (2+) channels that in turn increases release. |
1(0,0,0,1) | Details |