Protein Information

Name SCA1
Synonyms ATX 1; ATX1; ATXN 1; ATXN1; Ataxin 1; D6S504E; SCA1; Spinocerebellar ataxia type 1 protein…

Compound Information

Name 4-aminopyridine
CAS 4-pyridinamine

Reference List

PubMed Abstract RScore(About this table)
11287496 Inoue T, Lin X, Kohlmeier KA, Orr HT, Zoghbi HY, Ross WN: Calcium dynamics and electrophysiological properties of cerebellar Purkinje cells in SCA1 transgenic mice. J Neurophysiol. 2001 Apr;85(4):1750-60.

This delay was increased by hyperpolarizing prepulses and was eliminated by 4-aminopyridine, which suggests that this delay was due to enhancement of the A-like K (+) conductance in the SCA1 PCs.
13(0,0,1,8) Details