| Name | estrogen receptor |
|---|---|
| Synonyms | ER; ERA; ER alpha; ERalpha; ESR; ESR 1; ESR1; ESRA… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15464075 | Diaz M, Ramirez CM, Marin R, Marrero-Alonso J, Gomez T, Alonso R: Acute relaxation of mouse duodenum [correction of duodenun] by estrogens. Eur J Pharmacol. 2004 Oct 6;501(1-3):161-78. We hypothesize that the rapid non-genomic spasmolytic effect of estrogens on mouse duodenal muscle might be triggered by an estrogen-receptor-independent mechanism likely involving activation of tetraethylamonium- and 4-aminopyridine-sensitive K (+) channels and inhibition of L-type Ca2 (+) channels on the smooth muscle cells. |
82(1,1,1,2) | Details |
| 19406003 | Alda JO, Valero MS, Pereboom D, Gros P, Garay RP: Endothelium-independent vasorelaxation by the selective alpha estrogen receptor agonist propyl pyrazole triol in rat aortic smooth muscle. J Pharm Pharmacol. 2009 May;61(5):641-6. KEY FINDINGS: PPT vasorelaxation was largely reduced by the selective ERalpha antagonist methyl-piperidinopyrazole (MPP; -91.6+/-2.5%), by the selective PKG inhibitor Rp-8-Br- (-78.6+/-4.9%), by the specific soluble guanylyl cyclase inhibitor ODQ (1H-(1,2,4)-oxadiazolo [4,3-a] quinoxalin-1-one; -85.3+/-5.2%) and to a lesser extent by the selective BKCa (large-conductance - and voltage-activated potassium channel) inhibitor iberiotoxin (-59.3%), the selective IKCa (intermediate-conductance -activated potassium channel) inhibitor TRAM-34 (1-[(2-chlorophenyl) diphenylmethyl]-1H-pyrazole; -50.7%) and the voltage-gated potassium channel inhibitor 4-aminopyridine (-40.8%). |
34(0,1,1,4) | Details |
| 17322023 | Moritz A, Gust R, Pertz HH: Characterization of the relaxant response to N,N'-dipropyl-1,2-bis (2,6-dichloro-4-hydroxyphenyl) ethylenediamine in porcine coronary arteries. J Pharmacol Exp Ther. 2007 May;321(2):699-706. Epub 2007 Feb 22. The relaxant response to 8 was unaffected by the estrogen receptor antagonist ICI 182,780 (7alpha-[9-[(4,4,5,5,5-pentafluoropentyl]-sulfinyl] nonyl]-estra-1,3,5 (10)- triene-3,17beta-diol) and K+ channel blockers, i.e., TEA, glibenclamide, and 4-aminopyridine. |
32(0,1,1,2) | Details |
| 20164203 | Flinsenberg TW, Van der Sterren S, van Cleef AN, Schuurman MJ, Agren P, Villamor E: Effects of gender and on chicken ductus arteriosus reactivity. Am J Physiol Regul Integr Comp Physiol. 2010 Feb 17. In vitro contractions (assessed with a wire myograph) induced by normoxia, KCl, 4-aminopyridine, U46619, or endothelin-1 as well as relaxations induced by sodium nitroprusside, BAY 41-2272, isoproterenol, forskolin,Y-27632, and hydroxyfasudil were not significantly different between males and females. |
0(0,0,0,0) | Details |
| 11531164 | Nevala R, Paukku K, Korpela R, Vapaatalo H: -sensitive potassium channel inhibitors antagonize - and daidzein-induced arterial relaxation in vitro. Life Sci. 2001 Aug 10;69(12):1407-17. The antagonists of voltage-dependent K+-channels (K (V)) (4-aminopyridine), ATP-sensitive K+-channels (K (ATP)) (glibenclamide), or inward rectifier K+-channels (KIR) (barium) had no effect on the relaxation responses of any of the compounds studied. |
0(0,0,0,0) | Details |
| 16165285 | Fatehi M, Kombian SB, Saleh TM: 17beta- inhibits outward currents recorded in rat parabrachial nucleus cells in vitro. Neuroscience. 2005;135(4):1075-86. Epub 2005 Sep 13. The 17beta--induced inhibition of the outward current was blocked by pretreatment with the potassium channel blockers tetraethylammonium and 4-aminopyridine. |
0(0,0,0,0) | Details |