| Name | Rho kinase |
|---|---|
| Synonyms | NY REN 35 antigen; P160ROCK; ROCK 1; ROCK1; ROK alpha; ROKa; ROKalpha; Rho associated coiled coil containing protein kinase 1… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15769451 | Cogolludo A, Moreno L, Lodi F, Tamargo J, Perez-Vizcaino F: Postnatal maturational shift from PKCzeta and voltage-gated K+ channels to RhoA/Rho kinase in pulmonary vasoconstriction. Cardiovasc Res. 2005 Apr 1;66(1):84-93. Epub 2005 Jan 27. This was consistent with a greater contraction to the K (V) inhibitor, 4-aminopyridine, and with a leftward shift in the increase in intracellular Ca (2+) by U46619 in newborn versus older animals. |
4(0,0,0,4) | Details |
| 14592941 | Luykenaar KD, Brett SE, Wu BN, Wiehler WB, Welsh DG: Pyrimidine nucleotides suppress KDR currents and depolarize rat cerebral arteries by activating Rho kinase. Am J Physiol Heart Circ Physiol. 2004 Mar;286(3):H1088-100. Epub 2003 Oct 30. With patch-clamp electrophysiology, a voltage-dependent delayed rectifying K (+) current was isolated and shown to consist of a slowly inactivating 4-aminopyridine (4-AP)-sensitive and an -insensitive component. |
3(0,0,0,3) | Details |
| 19617310 | Cogolludo AL, Moral-Sanz J, van der Sterren S, Frazziano G, van Cleef AN, Menendez C, Zoer B, Moreno E, Roman A, Perez-Vizcaino F, Villamor E: Maturation of O2 sensing and signaling in the chicken ductus arteriosus. . Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L619-30. Epub 2009 Jul 17. Here we studied the role of the mitochondrial electron transport chain (ETC) as sensor, H (2) O (2) as mediator, and voltage-gated (K (V)) channels and Rho kinase as effectors of O (2)-induced contraction in the chicken DA during fetal development. The K (V) channel blocker 4-aminopyridine prevented the current inhibition elicited by O (2). |
2(0,0,0,2) | Details |
| 15678081 | Mraiche F, Cena J, Das D, Vollrath B: Effects of statins on vascular function of endothelin-1. . Br J Pharmacol. 2005 Mar;144(5):715-26. The Rho kinase inhibitor HA-1077 mimicked the effects of SV on tonic contractions induced by ET-1, NA and KCl. 6. Pretreatment with the Kv channels inhibitor, 4-aminopyridine, attenuated the ability of SV to relax contractions mediated by ET-1 and NA. 7. |
1(0,0,0,1) | Details |
| 18799631 | Greyner H, Dzialowski EM: Mechanisms mediating the -induced vasoreactivity of the ductus arteriosus in the chicken embryo. Am J Physiol Regul Integr Comp Physiol. 2008 Nov;295(5):R1647-59. Epub 2008 Sep 17. The O (2)-induced contraction is mediated by the Rho kinase pathway, as fasudil and Y-27632 significantly relax the O (2) contracted DA. The contractile response to O (2) matures during hatching and is mimicked by the K (v) channel inhibitor 4-aminopyridine (4-AP) on day 19 and externally pipped (EP) embryos. |
1(0,0,0,1) | Details |
| 19919833 | Dhaese I, Van Colen I, Lefebvre RA: Mechanisms of action of in relaxation of mouse distal colonic smooth muscle. Eur J Pharmacol. 2010 Feb 25;628(1-3):179-86. Epub 2009 Nov 15. The NaHS-induced relaxation was not influenced by the K (+) channels blockers glibenclamide, apamin, charybdotoxin, barium and 4-aminopyridine. |
0(0,0,0,0) | Details |