| Name | pituitary adenylate cyclase activating polypeptide |
|---|---|
| Synonyms | ADCYAP 1; ADCYAP1; Adenylate cyclase activating polypeptide 1; PACAP; PACAP related peptide; PACAP27; PACAP38; PRP48… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16019148 | Han P, Lucero MT: Pituitary adenylate cyclase activating polypeptide reduces A-type K+ currents and caspase activity in cultured adult mouse olfactory neurons. Neuroscience. 2005;134(3):745-56. Our observation that 5 mM 4-aminopyridine mimicked the caspase inhibiting effects of pituitary adenylate cyclase activating polypeptide indicates that A-type current is involved in apoptosis. |
90(1,1,2,5) | Details |
| 17498241 | Xu F, Tse FW, Tse A: Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates the sensing type I (glomus) cells of rat carotid bodies via reduction of a background TASK-like K+ current. J Neurochem. 2007 Jun;101(5):1284-93. In the presence of tetraethylammonium (TEA) and 4-aminopyridine (4-AP), PACAP reduced a background K (+) current. |
2(0,0,0,2) | Details |
| 11259781 | Miura A, Kawatani M, de Groat WC: Effects of pituitary adenylate cyclase activating polypeptide on lumbosacral preganglionic neurons in the neonatal rat spinal cord. Brain Res. 2001 Mar 23;895(1-2):223-32. PACAP suppressed a transient outward current that was also suppressed by 4-aminopyridine (0.5 mM). |
2(0,0,0,2) | Details |
| 15066141 | Mei YA, Vaudry D, Basille M, Castel H, Fournier A, Vaudry H, Gonzalez BJ: PACAP inhibits delayed rectifier current via a cAMP/PKA transduction pathway: evidence for the involvement of I k in the anti-apoptotic action of PACAP. Eur J Neurosci. 2004 Mar;19(6):1446-58. Because pituitary adenylate cyclase-activating polypeptide (PACAP) has been shown to inhibit the apoptotic cascade in the cerebellar cortex during development, we have investigated the effect of PACAP on K (+) currents in cultured cerebellar granule cells using the patch-clamp technique in the whole-cell configuration. |
1(0,0,0,1) | Details |