| Name | somatostatin |
|---|---|
| Synonyms | Growth hormone release inhibiting factor; SMST; SST; Somatostatin; Somatostatin precursor; Somatostatins; Somatostatin precursors |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11243423 | Murray F, Bell D, Kelso EJ, Millar BC, McDermott BJ: Positive and negative contractile effects of somatostatin-14 on rat ventricular cardiomyocytes. J Cardiovasc Pharmacol. 2001 Mar;37(3):324-32. In the presence of 4-aminopyridine (500 microM), somatostatin-14 stimulated a positive contractile response (EC50 = 118 fM) that was attenuated markedly by (100 nM). |
8(0,0,1,3) | Details |
| 17324523 | Galarraga E, Vilchis C, Tkatch T, Salgado H, Tecuapetla F, Perez-Rosello T, Perez-Garci E, Hernandez-Echeagaray E, Surmeier DJ, Bargas J: Somatostatinergic modulation of firing pattern and -activated currents in medium spiny neostriatal neurons. Neuroscience. 2007 May 11;146(2):537-54. Epub 2007 Feb 26. Somatostatin is synthesized and released by aspiny GABAergic interneurons of the neostriatum, some of them identified as low threshold spike generating neurons (LTS-interneurons). |
7(0,0,0,7) | Details |
| 19440689 | Braun M, Ramracheya R, Amisten S, Bengtsson M, Moritoh Y, Zhang Q, Johnson PR, Rorsman P: Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells. Diabetologia. 2009 Aug;52(8):1566-78. Epub 2009 May 14. Delta cells contained a -insensitive, Ba (2+)-sensitive inwardly rectifying K (+) current and two types of voltage-gated K (+) currents, sensitive to tetraethylammonium/stromatoxin (delayed rectifying, Kv2.1/2.2) and 4-aminopyridine (A current). |
6(0,0,0,6) | Details |
| 18665350 | Ristori C, Cammalleri M, Martini D, Pavan B, Liu Y, Casini G, Dal Monte M, Bagnoli P: Involvement of the cAMP-dependent pathway in the reduction of epileptiform bursting caused by somatostatin in the mouse hippocampus. Naunyn Schmiedebergs Arch Pharmacol. 2008 Dec;378(6):563-77. Epub 2008 Jul 30. Using a well-established model of epileptiform activity induced by Mg (2+)-free medium with 4-aminopyridine [0 Mg (2+)/4-aminopyridine (4-AP)] in mouse hippocampal slices, we demonstrated that protein kinase A (PKA)-related signaling is upregulated by hippocampal bursting and that treatment with SRIF normalizes this upregulation. |
2(0,0,0,2) | Details |
| 17706880 | Takeda M, Kadoi J, Takahashi M, Nasu M, Matsumoto S: Somatostatin inhibits the excitability of rat small-diameter trigeminal ganglion neurons that innervate nasal mucosa and project to the upper cervical dorsal horn via activation of somatostatin 2a receptor. Neuroscience. 2007 Sep 7;148(3):744-56. Epub 2007 Jul 17. In the presence of both 4-aminopyridine (6 mM) and tetraethylammonium (10 mM), no significant changes in the membrane potential in response to SST application were found. |
2(0,0,0,2) | Details |
| 15548214 | Cammalleri M, Cervia D, Langenegger D, Liu Y, Dal Monte M, Hoyer D, Bagnoli P: Somatostatin receptors differentially affect spontaneous epileptiform activity in mouse hippocampal slices. Eur J Neurosci. 2004 Nov;20(10):2711-21. Recordings of epileptiform discharge induced by Mg2+ -free medium with 4-aminopyridine were performed from the CA3 region before and after the application of SRIF compounds. |
2(0,0,0,2) | Details |
| 18329054 | Ristori C, Cammalleri M, Martini D, Pavan B, Casini G, Cervia D, Bagnoli P: The cyclooxygenase-2/ pathway is involved in the somatostatin-induced decrease of epileptiform bursting in the mouse hippocampus. Neuropharmacology. 2008 Apr;54(5):874-84. Epub 2008 Feb 3. |
2(0,0,0,2) | Details |
| 11790809 | Lien CC, Martina M, Schultz JH, Ehmke H, Jonas P: Gating, modulation and subunit composition of voltage-gated K (+) channels in dendritic inhibitory interneurones of rat hippocampus. J Physiol. 2002 Jan 15;538(Pt 2):405-19. We examined functional and molecular properties of K (+) channels in interneurones with horizontal dendrites in stratum oriens-alveus (OA) of the hippocampal CA1 region, which mainly comprise somatostatin-positive dendritic inhibitory cells. Voltage-gated K (+) currents in nucleated patches isolated from OA interneurones consisted of three major components: a fast delayed rectifier K (+) current component that was highly sensitive to external 4-aminopyridine (4-AP) and tetraethylammonium (TEA) (half-maximal inhibitory concentrations < 0.1 mM for both blockers), a slow delayed rectifier K (+) current component that was sensitive to high concentrations of TEA, but insensitive to 4-AP, and a rapidly inactivating A-type K (+) current component that was blocked by high concentrations of 4-AP, but resistant to TEA. |
1(0,0,0,1) | Details |