| Name | Substance P |
|---|---|
| Synonyms | Hs.2563; PPT; NK2; NKA; NKNA; Neurokinin 1; Neurokinin 2; Neurokinin A… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10725258 | Quignard JF, Feletou M, Edwards G, Duhault J, Weston AH, Vanhoutte PM: Role of endothelial cell hyperpolarization in EDHF-mediated responses in the guinea-pig carotid artery. Br J Pharmacol. 2000 Mar;129(6):1103-12. In isolated arteries, both the endothelium-dependent hyperpolarization of smooth muscle and the hyperpolarization of endothelial cells induced by or by substance P were inhibited by 5 mM 4-aminopyridine. 4. |
81(1,1,1,1) | Details |
| 15219818 | Jun JY, Choi S, Yeum CH, Chang IY, You HJ, Park CK, Kim MY, Kong ID, Kim MJ, Lee KP, So I, Kim KW: Substance P induces inward current and regulates pacemaker currents through tachykinin NK1 receptor in cultured interstitial cells of Cajal of murine small intestine. Eur J Pharmacol. 2004 Jul 8;495(1):35-42. Tetrodotoxin, nifedipine, tetraethylammonium, 4-aminopyridine, or glibenclamide did not change the frequency and amplitude of pacemaker currents. |
7(0,0,0,7) | Details |
| 17707373 | Yamane H, de Groat WC, Sculptoreanu A: Effects of ralfinamide, a Na+ channel blocker, on firing properties of nociceptive dorsal root ganglion neurons of adult rats. Exp Neurol. 2007 Nov;208(1):63-72. Epub 2007 Jul 19. In -responsive phasic neurons, substance P and 4-aminopyridine induced multiple spikes, an effect that was reversed by ralfinamide (25 microM). |
6(0,0,1,1) | Details |
| 10651867 | Ptak K, Konrad M, Di Pasquale E, Tell F, Hilaire G, Monteau R: Cellular and synaptic effect of substance P on neonatal phrenic motoneurons. Eur J Neurosci. 2000 Jan;12(1):126-38. In voltage-clamp mode, SP or the NK1 receptor agonist produced an inward current (ISP) which was not significantly reduced by extracellular application of tetraethylammonium, Co2+, 4-aminopyridine or Cs+. |
3(0,0,0,3) | Details |
| 17362934 | Sculptoreanu A, de Groat WC: Neurokinins enhance excitability in -responsive DRG neurons. . Exp Neurol. 2007 May;205(1):92-100. Epub 2007 Feb 14. In C-R neurons that generated only a few action potentials (APs, termed phasic) in response to long depolarizing current pulses (600 ms), substance P (SP, 0.5 microM) lowered the AP threshold by 11.0+/-0.3 mV and increased firing from 1.1+/-0.7 APs to 5.2+/-0.6 APs. The effects of SP were similar to the effect of heteropodatoxin II (0.05 microM) or low concentrations of 4-aminopyridine (50 microM) that block A-type K (+) currents. |
2(0,0,0,2) | Details |
| 11374879 | Denda M, Ashida Y, Inoue K, Kumazawa N: Skin surface electric potential induced by ion-flux through epidermal cell layers. Biochem Biophys Res Commun. 2001 Jun 1;284(1):112-7. Substance P and corticotropin-releasing factor decreased the potential, and antagonists blocked the decreases. |
1(0,0,0,1) | Details |
| 11522609 | Ohnishi Y, Hirano K, Nishimura J, Furue M, Kanaide H: Inhibitory effects of brefeldin A, a membrane transport blocker, on the bradykinin-induced hyperpolarization-mediated relaxation in the porcine coronary artery. Br J Pharmacol. 2001 Sep;134(1):168-78. In the presence of 10 microM indomethacin and 30 microM N (G)-nitro- (L-NOARG), both bradykinin and substance P induced a transient decrease in [Ca (2+)] i and tension in arterial strips contracted with 100 nM U46619 analogue). The indomethacin/L-NOARG-resistant relaxation induced by bradykinin was completely inhibited by 3 mM tetrabutylammonium (non-specific Ca (2+)-activated K (+) channel blocker), while that induced by substance P was not inhibited by 3 mM tetrabutylammonium or 1 mM 4-aminopyridine (voltage-dependent K (+) channels blocker) alone, but completely inhibited by their combination. 5. |
1(0,0,0,1) | Details |
| 17295025 | Gupta S, Lozano-Cuenca J, Villalon CM, de Vries R, Garrelds IM, Avezaat CJ, van Kats JP, Saxena PR, MaassenVanDenBrink A: Pharmacological characterisation of -induced relaxations in human and porcine isolated arteries. Naunyn Schmiedebergs Arch Pharmacol. 2007 Mar;375(1):29-38. Epub 2007 Feb 13. a pungent constituent from red chilli peppers, activates sensory nerve fibres via transient receptor potential vanilloid receptors type 1 (TRPV1) to release neuropeptides like calcitonin gene-related peptide (CGRP) and substance P. Further, we also used the K+ channel inhibitors 4-aminopyridine (1 mM), charybdotoxin (0.5 microM) + apamin (0.1 microM) and iberiotoxin (0.5 microM) + apamin (0.1 microM). |
1(0,0,0,1) | Details |
| 15010502 | Sculptoreanu A, Yoshimura N, de Groat WC: KW-7158 [(2S)-(+)-3,3,3-trifluoro-2--2-methyl-N-(5,5,10-trioxo-4,10-dihydro thieno [3,2-c][1] benzothiepin-9-yl) propanamide] enhances A-type K+ currents in neurons of the dorsal root ganglion of the adult rat. J Pharmacol Exp Ther. 2004 Jul;310(1):159-68. Epub 2004 Mar 9. Low concentrations of KW-7158 shortened the action potential duration, produced a 5- to 10-mV hyperpolarization, and inhibited repetitive firing induced by either 4-AP (50 microM) or substance P (0.5 microM) in phasic firing DRG neurons. |
1(0,0,0,1) | Details |
| 10611463 | Andre E, Malheiros A, Cechinel-Filho V, Yunes RA, Calixto JB: Mechanisms underlying the relaxation caused by the sesquiterpene polygodial in vessels from rabbit and guinea-pig. Eur J Pharmacol. 1999 Dec 10;386(1):47-53. In contrast, N (omega)-nitro- (D-NOARG), indomethacin, N (2)-[(4R)-4--1-(1methyl-1H-indol-3yl) carbonyl-L-prol yl]-N-met hyl-N-phenylmethyl-3-(2-naphthyl)-L-alaninamide (FK 888), (S)-N-methyl-N [4-(4-acetylamino-4-phenylpiperidino)-2-(3, 4-dichlorophenyl) butyl] benzamide (SR 48968), (8R,9S, 11S)-(-)-9--9-n-hexyloxy-carbonyl-8-methyl-2,3,9, 20-tetrahydro-8,11-epoxy-1H,8H,11H-2,7b,11a-triaqzadibenzo [a, g] cycloocta [c,d,e]-trinden-1-one (KT 5720), calcitocin gene-related peptide receptor antagonist (CGRP-(8-37), apamin, charybdotoxin and 4-aminopyridine had no effect on polygodial action. |
0(0,0,0,0) | Details |