| Name | adenosine A1 receptor |
|---|---|
| Synonyms | A1AR; ADORA 1; ADORA1; Adenosine A1 receptor; RDC 7; RDC7; Adenosine A1 receptors |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15003280 | Harrison PK, Tattersall JE, Clement RA: Periodic orbit analysis reveals subtle effects of atropine on epileptiform activity in the guinea-pig hippocampal slice. Neurosci Lett. 2004 Mar 11;357(3):183-6. We have used a recently developed mathematical technique based on periodic orbit analysis to investigate the effect of atropine (a muscarinic antagonist) on epileptiform activity induced by soman (an irreversible acetylcholinesterase inhibitor), 4-aminopyridine (a K+ channel blocker) and 8-cyclopentyl-1,3-dipropylxanthine (an adenosine A1 receptor antagonist) in the guinea-pig hippocampal slice. |
31(0,1,1,1) | Details |
| 15031302 | Harrison PK, Sheridan RD, Green AC, Scott IR, Tattersall JE: A guinea pig hippocampal slice model of organophosphate-induced seizure activity. J Pharmacol Exp Ther. 2004 Aug;310(2):678-86. Epub 2004 Mar 18. In contrast to soman-induced epileptiform activity, bursting induced by the K (+) channel blocker 4-aminopyridine (30 microM), the adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (30 nM) or perfusion with low Mg (2+) buffer was insensitive to atropine (10 microM). |
31(0,1,1,1) | Details |
| 11026447 | Dzhala V, Ben-Ari Y, Khazipov R: Seizures accelerate anoxia-induced neuronal death in the neonatal rat hippocampus. Ann Neurol. 2000 Oct;48(4):632-40. Aggravation of electrographic seizure activity during anoxic episodes by the adenosine A1 receptor antagonists DPCPX and or the -A receptor antagonist bicuculline or pretreatment with 4-aminopyridine accelerated AD and associated neuronal death by up to twofold, whereas blockade of seizure activity by the glutamate receptor antagonists or tetrodotoxin significantly delayed the onset of AD. |
31(0,1,1,1) | Details |
| 17372967 | Wang SJ: facilitation of release from rat cerebral cortex nerve terminals (synaptosomes) through activation protein kinase C pathway: an interaction with presynaptic adenosine A1 receptors. Synapse. 2007 Jun;61(6):401-11. The present study used nerve terminals (synaptosomes) isolated from rat cerebral cortex to investigate the relationship between and 4-aminopyridine (4AP)-evoked endogenous excitatory neurotransmitter release. |
2(0,0,0,2) | Details |
| 10670420 | Jarolimek W, Baurle J, Misgeld U: Impaired inhibition of epileptiform activity by baclofen, but not by in the weaver hippocampus. Neuropharmacology. 2000 Jan 4;39(2):246-53. Endogenous and adenosine A1 receptor agonists differed only slightly in their efficacy to inhibit spontaneous synchronous burst discharges in wv/wv and +/+ mice. |
1(0,0,0,1) | Details |
| 12626609 | Jeong HJ, Jang IS, Nabekura J, Akaike N: Adenosine A1 receptor-mediated presynaptic inhibition of GABAergic transmission in immature rat hippocampal CA1 neurons. J Neurophysiol. 2003 Mar;89(3):1214-22. K (+) channel blockers, 4-aminopyridine (100 microM) and Ba (2+) (1 mM), had no effect on the inhibitory effect of CPA on GABAergic mIPSC frequency. |
1(0,0,0,1) | Details |