| Name | TASK 2 |
|---|---|
| Synonyms | Acid sensitive potassium channel protein TASK 2; KCNK 5; KCNK5; Potassium channel subfamily K member 5; TASK 2; TASK2; TWIK related acid sensitive K(+) channel 2; TWIK related acid sensitive K+ channel 2… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16432512 | Gonczi M, Szentandrassy N, Johnson IT, Heagerty AM, Weston AH: Investigation of the role of TASK-2 channels in rat pulmonary arteries; pharmacological and functional studies following RNA interference procedures. Br J Pharmacol. 2006 Mar;147(5):496-505. The application of levcromakalim (10 microM), NS1619 (33 microM) and a potassium channel inhibitor cocktail (5 mM 4-aminopyridine, 10 mM tetraethylammonium 30 microM Ba2+ and 10 microM glibenclamide) had similar effects in control and in siRNA-transfected vessels. |
4(0,0,0,4) | Details |
| 16421215 | Barfield JP, Yeung CH, Cooper TG: Characterization of channels involved in volume regulation of human spermatozoa. Mol Hum Reprod. 2005 Dec;11(12):891-7. Epub 2006 Jan 18. Regulation of cellular volume, as measured by flow cytometry, was inhibited when spermatozoa were exposed to quinine (QUI; 0.3 mM), 4-aminopyridine (4AP; 4 mM) and clofilium (CLO; 10 microM) which suggests the involvement of voltage-gated K+ channels Kv1.4, Kv1.5 and Kv1.7, acid-sensitive channel TASK2 and the beta-subunit minK (IsK) in regulatory volume decrease (RVD). Furthermore, Kv1.5, minK and TASK2 were localized to various regions of the spermatozoa. |
2(0,0,0,2) | Details |
| 15673604 | Barfield JP, Yeung CH, Cooper TG: The effects of putative K+ channel blockers on volume regulation of murine spermatozoa. Biol Reprod. 2005 May;72(5):1275-81. Epub 2005 Jan 26. The presence of quinine (0.8 mM), cadmium (0.2 mM), flecainide (100 microM), 4-aminopyridine (4 mM), barium (1 mM), clofilium (10 microM), and phrixotoxin (100 nM) for 75 min resulted in significantly higher forward scatter values than sperm incubated in medium without an inhibitor. These results imply that channels potentially involved in volume regulation of murine spermatozoa include the voltage-dependent Kv1.4 (also known as KCNA1), Kv1.5 (KCNA5), Kv4.1 (KCND1), Kv4.2 (KCND2), Kv4.3 (KCND3), mink (KCNE1), and acid-sensitive TASK2 (KCNK5) and TASK3 (KCNK9). |
2(0,0,0,2) | Details |
| 15066906 | Gardener MJ, Johnson IT, Burnham MP, Edwards G, Heagerty AM, Weston AH: Functional evidence of a role for two-pore domain channels in rat mesenteric and pulmonary arteries. Br J Pharmacol. 2004 May;142(1):192-202. Epub 2004 Apr 5. RT-PCR demonstrated the expression of TASK-1, TASK-2, THIK-1, TRAAK, TREK-1, TWIK-1 and TWIK-2 in mesenteric arteries and TASK-1, TASK-2, THIK-1, TREK-2 and TWIK-2 in pulmonary arteries. K (+) channel blockade by 4-aminopyridine (4-AP) (5 mm), tetraethylammonium (TEA) (10 mm), Ba (2+) (30 microm) and glibenclamide (10 microm) depolarised the pulmonary artery. |
2(0,0,0,2) | Details |
| 15774516 | Cho SY, Beckett EA, Baker SA, Han I, Park KJ, Monaghan K, Ward SM, Sanders KM, Koh SD: A pH-sensitive conductance (TASK) and its function in the murine gastrointestinal tract. J Physiol. 2005 May 15;565(Pt 1):243-59. Epub 2005 Mar 17. TASK-2, cloned from murine intestinal muscles, resulted in a pH-sensitive, time-dependent, non-inactivating K+ conductance with slow activation kinetics. The effects of lidocaine were not blocked by tetraethylammonium 4-aminopyridine, glibenclamide, apamin or MK-499. |
2(0,0,0,2) | Details |
| 18394011 | Beckett EA, Han I, Baker SA, Han J, Britton FC, Koh SD: Functional and molecular identification of pH-sensitive K+ channels in murine urinary bladder smooth muscle. BJU Int. 2008 Jul;102(1):113-24. Epub 2008 Apr 3. RT-PCR showed the expression of the acid-sensitive K (+) channel (TASK)-1 and TASK-2 gene transcripts in murine bladder, and immunohistochemistry and Western blot analysis showed TASK-1 and TASK-2 channel expression and distribution in smooth muscle tissues and cells. Pre-treatment of bladder myocytes with the classical K (+) antagonists tetraethylammonium (10 mm), 4-aminopyridine (5 mM), glibenclamide (10 microm) or apamin (300 nM) did not inhibit the effects of low pH on outward current. |
1(0,0,0,1) | Details |