| Name | Ca v |
|---|---|
| Synonyms | CA V; CA VA; CA5; CA5A; CAV; CAVA; Carbonate dehydratase VA; Carbonic anhydrase V… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16686648 | Weiergraber M, Henry M, Krieger A, Kamp M, Radhakrishnan K, Hescheler J, Schneider T: Altered seizure susceptibility in mice lacking the Ca (v) 2.3 E-type Ca2+ channel. Epilepsia. 2006 May;47(5):839-50. In addition, convulsive seizure activity was induced by systemic administration of either 4-aminopyridine (4-AP; 10 mg/kg, i.p.) or pentylenetetrazol (PTZ; 80 mg/kg, s.c.) to reveal possible alterations in seizure susceptibility. |
7(0,0,0,7) | Details |
| 17699699 | Cataldi M, Lariccia V, Marzaioli V, Cavaccini A, Curia G, Viggiano D, Canzoniero LM, di Renzo G, Avoli M, Annunziato L: Zn (2+) slows down Ca (V) 3.3 gating kinetics: implications for thalamocortical activity. J Neurophysiol. 2007 Oct;98(4):2274-84. Epub 2007 Aug 15. In line with this finding, we discovered that chelation of endogenous Zn (2+) decreased the frequency of occurrence of ictal-like epileptiform discharges in rat thalamocortical slices perfused with medium containing the convulsant 4-aminopyridine (50 microM). |
3(0,0,0,3) | Details |
| 17395137 | Strupp M, Zwergal A, Brandt T: Episodic ataxia type 2. . Neurotherapeutics. 2007 Apr;4(2):267-73. EA 2 is caused most often by the loss of function mutations of the calcium channel gene CACNA1A, which encodes the Ca (v) 2.1 subunit of the P/Q-type calcium channel and is primarily expressed in Purkinje cells. Two effective treatment options have been established for EA 2: acetazolamide (ACTZ), which probably changes the intracellular pH and thereby the transmembraneous potential, and 4-aminopyridine (4-AP), a potassium channel blocker. |
1(0,0,0,1) | Details |
| 19302149 | Ladera C, Martin R, Bartolome-Martin D, Torres M, Sanchez-Prieto J: Partial compensation for N-type Ca (2+) channel loss by P/Q-type Ca (2+) channels underlines the differential release properties supported by these channels at cerebrocortical nerve terminals. Eur J Neurosci. 2009 Mar;29(6):1131-40. In addition, we have determined the release properties at terminals from mice lacking the alpha (1B) subunit of N-type channels (Ca (v) 2.2) to test the possibility that P/Q-type channels can compensate for the loss of N-type Ca (2+) channels. |
1(0,0,0,1) | Details |
| 15843617 | Weisz CJ, Raike RS, Soria-Jasso LE, Hess EJ: Potassium channel blockers inhibit the triggers of attacks in the calcium channel mouse mutant tottering. J Neurosci. 2005 Apr 20;25(16):4141-5. Both the human and mouse disorders result from mutations in CACNA1A, the gene encoding the alpha (1) 2.1 subunit of Ca (v) 2.1 voltage-gated channels. These mutations predict reduced currents, particularly in cerebellar Purkinje cells, where these channels are most abundant. 4-Aminopyridine (4-AP), a nonselective blocker of K (v) voltage-gated potassium channels, alleviates attacks of ataxia in EA2 patients. |
1(0,0,0,1) | Details |
| 19955484 | Jiang P, Rushing SN, Kong CW, Fu J, Lieu DK, Chan CW, Deng W, Li RA: Electrophysiological properties of human induced pluripotent stem cells. . Am J Physiol Cell Physiol. 2010 Mar;298(3):C486-95. Epub 2009 Dec 2. By contrast, 4-aminopyridine (4-AP) inhibited viability (EC (50) = 4.5 +/- 0.5 mM) but had less effect on proliferation (EC (50) = 0.9 +/- 0.5 mM). |
0(0,0,0,0) | Details |
| 16091557 | Wang K, Xue T, Tsang SY, Van Huizen R, Wong CW, Lai KW, Ye Z, Cheng L, Au KW, Zhang J, Li GR, Lau CP, Tse HF, Li RA: Electrophysiological properties of pluripotent human and mouse embryonic stem cells. Stem Cells. 2005 Nov-Dec;23(10):1526-34. Epub 2005 Aug 9. In mESCs, tetraethylammonium (TEA)-sensitive depolarization-activated delayed rectifier K+ currents (IK (DR)) (8.6 +/- 0.9 pA/pF at +40 mV; IC50 = 1.2 +/- 0.3 mM), which contained components sensitive to 4-aminopyridine (4-AP) (IC50 = 0.5 +/- 0.1 mM) and 100 nM Ca2+-activated K+ current (IK (Ca)) blocker iberiotoxin (IBTX),were detected in 52.3% of undifferentiated cells.IK (DR) was similarly present in hESCs (approximately 100%) but with an approximately sixfold higher current density (47.5 +/- 7.9 pA/pF at +40 mV). |
0(0,0,0,0) | Details |