| Name | adenylate cyclase |
|---|---|
| Synonyms | AH related protein; HCA2; ATP pyrophosphate lyase; Adenylate cyclase; Adenylyl cyclase soluble; HCA 2; RP1 313L4.2; SAC… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15034129 | Daniel H, Rancillac A, Crepel F: Mechanisms underlying cannabinoid inhibition of presynaptic Ca2+ influx at parallel fibre synapses of the rat cerebellum. J Physiol. 2004 May 15;557(Pt 1):159-74. Epub 2004 Mar 19. The present study demonstrates that the molecular mechanisms underlying the CB1 inhibitory effect involve the activation of the PTX-sensitive G (i)/G (o) subclass of G proteins, independently of any direct effect on presynaptic Ca (2+) channels (N, P/Q and R (SNX-482-sensitive) types) or on adenylate cyclase or MAPK activity, but do require the activation of G protein-gated inwardly rectifying (Ba (2+)- and tertiapin Q-sensitive) K (+) channels, in addition to 4-aminopyridine-sensitive K (+) channels. |
82(1,1,1,2) | Details |
| 16234412 | Lin RJ, Wu BN, Lo YC, An LM, Dai ZK, Lin YT, Tang CS, Chen IJ: A -based epithelium-dependent airway relaxant KMUP-3 (7-[2-[4-(4-nitrobenzene) piperazinyl] ethyl]- increases respiratory performance and protects against tumor necrosis factor-alpha-induced tracheal contraction, involving release and expression of and protein kinase G. J Pharmacol Exp Ther. 2006 Feb;316(2):709-17. Epub 2005 Oct 18. In isolated trachea precontracted with carbachol, KMUP-3 (10-100 microM)-caused relaxations were attenuated by epithelium removal and by pretreatments with an inhibitor of K (+) channel, tetraethylammonium (10 mm); K (ATP) channel, glibenclamide (1 microM); voltage-dependent K (+) channel, 4-aminopyridine (100 microM); Ca (2+)-dependent K (+) channel, charybdotoxin (0.1 microM) or apamin (1 microM); soluble guanylate cyclase (sGC), 1H-[1,2,4] oxadiazolo [4,3-a] quinoxalin-1one (ODQ, 1 microM); (NO) synthase, N (omega)-nitro- methyl ester (L-NAME, 100 microM); and adenylate cyclase, SQ 22536 [9-(terahydro-2-furanyl)- (100 microM). |
31(0,1,1,1) | Details |
| 15237094 | Wu BN, Lin RJ, Lo YC, Shen KP, Wang CC, Lin YT, Chen IJ: KMUP-1, a derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels. Br J Pharmacol. 2004 Aug;142(7):1105-14. Epub 2004 Jul 5. Tracheal relaxation induced by KMUP-1 was attenuated by epithelium removal and by pretreatment with inhibitors of soluble guanylate cyclase (sGC) (1H-[1,2,4] oxadiazolo [4,3-a] quinoxalin-1-one (ODQ), 1 microm), synthase (Nomega-nitro- methyl ester, 100 microm), K+ channels (tetraethylammonium, 10 mm), KATP channels (glibenclamide, 1 microm), voltage-dependent K+ channels (4-aminopyridine, 100 microm) and Ca2+-dependent K+ channels (charybdotoxin, 0.1 microm or apamin, 1 microm). These increases in cyclic AMP and cyclic GMP were abolished in the presence of an adenylate cyclase inhibitor SQ 22536 (100 microm) and an sGC inhibitor ODQ (10 microm), respectively. |
1(0,0,0,1) | Details |
| 16436472 | Xu F, Xu J, Tse FW, Tse A: stimulates depolarization and rise in cytoplasmic [Ca2+] in type I cells of rat carotid bodies. Am J Physiol Cell Physiol. 2006 Jun;290(6):C1592-8. Epub 2006 Jan 25. Our results suggest that acting via the adenylate cyclase and PKA pathways, inhibits the TASK-1 K+ channels. Although was reported to inhibit a 4-aminopyridine (4-AP)-sensitive K+ current, 4-AP failed to trigger any [Ca2+] i rise, or to attenuate the response. |
1(0,0,0,1) | Details |
| 11801366 | Doi A, Ishibashi H, Jinno S, Kosaka T, Akaike N: Presynaptic inhibition of GABAergic miniature currents by metabotropic glutamate receptor in the rat CNS. Neuroscience. 2002;109(2):299-311. The application of K+ channel blockers such as 4-aminopyridine, Cs+, Ba2+ or tetraethylammonium increased the mIPSC frequency, but failed to inhibit the tACPD action on mIPSC. Forskolin, an activator of adenylate cyclase, facilitated the mIPSC frequency in a concentration-dependent manner and inhibited the tACPD-induced suppression of mIPSC frequency. 8-Br-cAMP, a membrane permeable analog of cAMP, also prevented the inhibitory action of tACPD. |
1(0,0,0,1) | Details |
| 16153635 | Zhang Y, Pertens E, Janssen LJ: 8-isoprostaglandin E (2) activates Ca (2+)-dependent K (+) current via cyclic AMP signaling pathway in murine renal artery. Eur J Pharmacol. 2005 Sep 27;520(1-3):22-8. This augmentation was observed in the presence of 4-aminopyridine (4-AP, 10 (-3) M) but not that of charybdotoxin (Ch Tx, 10 (-7) M). The isoprostane-induced augmentation was prevented by the ryanodine receptor blocker ruthenium red (10 (-5) M) or the adenylate cyclase blocker SQ 22536 (10 (-4) M). |
1(0,0,0,1) | Details |
| 11284450 | Tanaka Y, Mitani A, Igarashi T, Someya S, Otsuka K, Imai T, Yamaki F, Tanaka H, Saitoh M, Nakazawa T, Noguchi K, Hashimoto K, Shigenobu K: HNS-32, a novel azulene-1-carboxamidine derivative, inhibits nifedipine-sensitive and -insensitive contraction of the isolated rabbit aorta. Naunyn Schmiedebergs Arch Pharmacol. 2001 Mar;363(3):344-52. Relaxation elicited by HNS-32 was not affected by the adenylate cyclase inhibitor, 9-(tetrahydro-2'-furyl) (SQ 22,536, 10 (-4) M), the soluble guanylate cyclase inhibitor, 1H-(1,2,4)-oxadiazolo-(4,3-a)-quinoxalin-1-one (ODQ, 10 (-5) M) or a cocktail of K+ channel blockers (glybenclamide 10 (-6) M, tetraethylammonium 2x10 (-3) M, apamin 10 (-7) M, 4-aminopyridine 10 (-4) M and Ba2+ 10 (-5) M). |
0(0,0,0,0) | Details |
| 19919833 | Dhaese I, Van Colen I, Lefebvre RA: Mechanisms of action of in relaxation of mouse distal colonic smooth muscle. Eur J Pharmacol. 2010 Feb 25;628(1-3):179-86. Epub 2009 Nov 15. The NaHS-induced relaxation was not influenced by the K (+) channels blockers glibenclamide, apamin, charybdotoxin, barium and 4-aminopyridine. |
0(0,0,0,0) | Details |
| 16151435 | Wu BN, Tu HF, Welsh DG, Chen IJ: KMUP-1 activates BKCa channels in basilar artery myocytes via cyclic nucleotide-dependent protein kinases. Br J Pharmacol. 2005 Nov;146(6):862-71. BKCa current activation by KMUP-1 was markedly inhibited by a soluble guanylate cyclase inhibitor (ODQ 10 microM), an adenylate cyclase inhibitor (SQ 22536 10 microM), competitive antagonists of and cAMP (Rp- 100 microM and Rp-cAMP, 100 microM), and - and cAMP-dependent protein kinase inhibitors (KT5823, 300 nM and KT5720, 300 nM). |
1(0,0,0,1) | Details |
| 15201307 | Yang K, Fujita T, Kumamoto E: inhibits GABAergic and glycinergic transmission in adult rat substantia gelatinosa neurons. J Neurophysiol. 2004 Nov;92(5):2867-77. Epub 2004 Jun 16. This reduction in frequency disappeared in the presence of a K+ -channel blocker (4-aminopyridine) but not in the absence of Ca2+. |
0(0,0,0,0) | Details |
| 11150326 | Robbe D, Alonso G, Duchamp F, Bockaert J, Manzoni OJ: Localization and mechanisms of action of cannabinoid receptors at the glutamatergic synapses of the mouse nucleus accumbens. J Neurosci. 2001 Jan 1;21(1):109-16. The K (+) channel blockers 4-aminopyridine (100 micrometer) and BaCl (2) (300 micrometer) each reduced by 40-50% the inhibitory actions of WIN-2, and their effects were additive. |
0(0,0,0,0) | Details |
| 12548092 | Andre E, Malheiros A, Cechinel-Filho V, Yunes RA, Calixto JB: Role of and K+ channels in relaxation induced by polygodial in rabbit corpus cavernosum in vitro. J Cardiovasc Pharmacol. 2003 Feb;41(2):300-6. In contrast, apamin, charybdotoxin, and 4-aminopyridine or the protein kinase A inhibitor KT 5720 all failed to affect either polygodial or -mediated relaxation in these preparations. |
0(0,0,0,0) | Details |
| 12491798 | Horinouchi T, Tanaka Y, Koike K: [Beta 3-adrenoceptor-mediated relaxation of guinea-pig gastric funds smooth muscle: cAMP-independent characteristics and a primary role of 4-aminopyridine-sensitive voltage-dependent K+ (Kv) channels]. Nippon Yakurigaku Zasshi. 2002 Nov;120(1):109P-111P. |
0(0,0,0,0) | Details |