| Name | neuropeptide Y |
|---|---|
| Synonyms | NPY; Neuropeptide Y; Neuropeptide Y precursor; PYY 4; PYY4; Y Neuropeptide; Neuropeptide ies; Neuropeptide Y precursors… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16026936 | Wang SJ: Activation of neuropeptide Y Y1 receptors inhibits release through reduction of voltage-dependent Ca2+ entry in the rat cerebral cortex nerve terminals: suppression of this inhibitory effect by the protein kinase C-dependent facilitatory pathway. Neuroscience. 2005;134(3):987-1000. NPY inhibited the Ca2+-dependent release evoked by 4-aminopyridine, and this inhibitory effect was mediated via NPY Y1 receptors, because it was mimicked by the specific NPY Y1 receptor agonist [Leu31 Pro34] NPY and blocked by the NPY Y1 receptor antagonist GR 231118. |
2(0,0,0,2) | Details |
| 11934810 | Heredia MP, Fernandez-Velasco M, Benito G, Delgado C: Neuropeptide Y increases 4-aminopyridine-sensitive transient outward current in rat ventricular myocytes. Br J Pharmacol. 2002 Apr;135(7):1701-6. The modulation of 4-aminopyridine sensitive transient outward current (4-AP I (to)) by neuropeptide Y (NPY) (100 nM) in rat ventricular myocytes was examined using the whole cell voltage-clamp technique. 2. |
37(0,1,2,2) | Details |
| 11588116 | MacLean MR, Morecroft I: Increased contractile response to 5-hydroxytryptamine1-receptor stimulation in pulmonary arteries from chronic hypoxic rats: role of pharmacological synergy. Br J Pharmacol. 2001 Oct;134(3):614-20. Here we investigate the influence of vascular tone induced by endothelin-1 (ET-1), neuropeptide Y (NPY), KCl, 4-aminopyridine (inactivator of K (v) channels, 4-AP) or the ionophore A23187 on contractile responses to the (1)-receptor agonist 5-carboxamidotryptamine (5-CT) in small muscular pulmonary arteries from control rats and rats exposed to chronic hypoxia. |
31(0,1,1,1) | Details |
| 19487123 | Kameda M, Kobayashi K, Ito H, Miyazoe H, Tsujino T, Nakama C, Kawamoto H, Ando M, Ito S, Suzuki T, Kanno T, Tanaka T, Tahara Y, Tani T, Tanaka S, Tokita S, Sato N: Optimization of a series of 2,4-diaminopyridines as neuropeptide Y Y1 receptor antagonists with reduced hERG activity. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4325-9. Epub 2009 May 24. |
2(0,0,0,2) | Details |
| 19640706 | Kameda M, Ando M, Nakama C, Kobayashi K, Kawamoto H, Ito S, Suzuki T, Tani T, Ozaki S, Tokita S, Sato N: Synthesis and evaluation of a series of 2,4-diaminopyridine derivatives as potential positron emission tomography tracers for neuropeptide Y Y1 receptors. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5124-7. Epub 2009 Jul 10. |
2(0,0,0,2) | Details |
| 11668080 | Chlopicki S, Nilsson H, Mulvany MJ: Initial and sustained phases of myogenic response of rat mesenteric small arteries. Am J Physiol Heart Circ Physiol. 2001 Nov;281(5):H2176-83. With slight preconstriction and neuropeptide Y), pressure was raised from 60 to 100 mmHg, and both initial (within 2 min) and sustained phases (at 10 min) of the myogenic response were quantified. Apamin, glibenclamide, 4-aminopyridine, and barium had no effect on either phase. |
1(0,0,0,1) | Details |
| 15097991 | van den Top M, Lee K, Whyment AD, Blanks AM, Spanswick D: Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus. Nat Neurosci. 2004 May;7(5):493-4. Epub 2004 Apr 18. Here we show that rat ARC neurons containing neuropeptide Y (NPY) and agouti-related protein (AgRP), which are conditional pacemakers, are activated by orexigens and inhibited by the anorexigen leptin. |
1(0,0,0,1) | Details |