| Name | ET A |
|---|---|
| Synonyms | EDNRA; ET A; ETA; ETA R; ETRA; Endothelin A receptor; Endothelin 1 receptor; Endothelin 1 receptor precursor… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12359274 | Berg T: Analysis of the pressor response to the K+ channel inhibitor 4-aminopyridine. Eur J Pharmacol. 2002 Oct 11;452(3):325-37. |
0(0,0,0,0) | Details |
| 10864884 | Betts LC, Kozlowski RZ: Electrophysiological effects of endothelin-1 and their relationship to contraction in rat renal arterial smooth muscle. Br J Pharmacol. 2000 Jun;130(4):787-96. Pharmacological experiments revealed that ET-1 produced constriction of renal arteries dependent on the influx of extracellular Ca (2+), mediated solely through ET (A) receptor stimulation. |
3(0,0,0,3) | Details |
| 16917023 | Agren P, Cogolludo AL, Kessels CG, Perez-Vizcaino F, De Mey JG, Blanco CE, Villamor E: Ontogeny of chicken ductus arteriosus response to and vasoconstrictors. Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R485-96. Epub 2006 Aug 17. On embryonic day 15, the chicken DA did not respond to O (2) (0 to 21%), (NE), or but contracted in response to high-K (+) solution, the inhibitor of voltage-gated channels 4-aminopyridine, U-46619, and endothelin (ET)-1. -induced contraction was restricted to the pulmonary side of the DA and was augmented by the synthase inhibitor N (omega)-nitro- methyl ester and the soluble guanylate cyclase inhibitor 1H-[1,2,4] oxadiazolo [4,3-a] quinoxalin-1-one and reduced by the peptidic ET (A) and ET (B)-receptor antagonist PD-142,893. |
1(0,0,0,1) | Details |
| 15821751 | O'Sullivan SE, Kendall DA, Randall MD: The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid Br J Pharmacol. 2005 Jun;145(4):514-26. 1 Delta9-tetrahydrocannabinol (THC) produces varying effects in mesenteric arteries: vasorelaxation (third-order branches, G3), modest vasorelaxation (G2), no effect (G1) and vasoconstriction (the superior mesenteric artery, G0). 2 In G3, vasorelaxation to THC was inhibited by pertussis toxin, but was unaffected by the CB1 receptor antagonist, AM251 (1 microM), incubation with the TRPV1 receptor agonist (10 microM, 1 h), the TRPV1 receptor antagonist capsazepine (10 microM) or de-endothelialisation. 3 In G3, vasorelaxation to THC was inhibited by high K+ buffer, and by the following K+ channel inhibitors: charybdotoxin (100 nM), apamin (500 nM) and barium (30 microM), but not by 4-aminopyridine, glibenclamide or tertiapin. 4 In G3, THC (10 and 100 microM) inhibited the contractile response to Ca2+ in a Ca2+-free, high potassium buffer, indicating that THC blocks Ca2+ influx. 5 In G0, the vasoconstrictor responses to THC were inhibited by de-endothelialisation and SR141716A (100 nM), but not by the endothelin (ET (A)) receptor antagonist FR139317 (1 microM).THC (1 and 10 microM) antagonised vasorelaxation to in G3 but not G0. |
0(0,0,0,0) | Details |
| 12694813 | Berg T: The vascular response to the K+ channel inhibitor 4-aminopyridine in hypertensive rats. Eur J Pharmacol. 2003 Apr 18;466(3):301-10. These results indicated an increased catecholamine, angiotensin AT (1) and endothelin ET (A) activation of the phospholipase C-protein kinase C pathway in SHR, inhibiting the 4-aminopyridine-sensitive K+ channels. |
32(0,1,1,2) | Details |