| Name | HM 1 |
|---|---|
| Synonyms | HM 1; U1 snRNP binding protein homolog; U11/U12 snRNP 35K; U1SNRNPBP; U1 snRNP binding protein homologs; U11/U12 snRNP 35Ks |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18045622 | Wang Y, Shi JG, Wang MZ, Che CT, Yeung JH: Mechanisms of the vasorelaxant effect of 1, 5-dihydroxy-2, 3-dimethoxy-xanthone, an active metabolite of 1--2, 3, 5-trimethoxy-xanthone isolated from a Tibetan herb, Halenia elliptica, on rat coronary artery. Life Sci. 2008 Jan 2;82(1-2):91-8. Epub 2007 Nov 1. Recently, it has been shown that HM-5 is one of the phase I metabolites of 1--2, 3, 5-trimethoxy-xanthone (HM-1), the major active component of H. elliptica with potent vasorelaxant actions. In endothelium-denuded coronary artery rings, the vasorelaxant effect of HM-5 was inhibited by a potassium channel blocker, TEA (10 mM), and 4-aminopyridine (4-AP, a K (v) blocker; 1 mM) but not by other K+ channel blockers such as iberiotoxin (100 nM), barium (100 microM) and glibenclamide (10 microM). |
2(0,0,0,2) | Details |
| 17822718 | Wang Y, Shi JG, Wang MZ, Che CT, Yeung JH: Mechanisms of the vasorelaxant effect of 1--2, 3, 5-trimethoxy-xanthone, isolated from a Tibetan herb, Halenia elliptica, on rat coronary artery. Life Sci. 2007 Sep 1;81(12):1016-23. Epub 2007 Aug 17. In endothelium-denuded coronary artery rings, the vasorelaxant effect of HM-1 was unaffected by potassium channel blockers such as tetraethylammonium (10 mM), iberiotoxin (100 nM), barium (100 microM) and 4-aminopyridine (1 mM). |
13(0,0,1,8) | Details |