| Name | SAP97 |
|---|---|
| Synonyms | DLG 1; DLG1; DLGH 1; DLGH1; Disks large homolog 1; Presynaptic protein SAP97; SAP 97; SAP97… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18245566 | Abi-Char J, El-Haou S, Balse E, Neyroud N, Vranckx R, Coulombe A, Hatem SN: The anchoring protein SAP97 retains Kv1.5 channels in the plasma membrane of cardiac myocytes. Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1851-61. Epub 2008 Feb 1. Adenovirus-mediated SAP97 overexpression in cardiac myocytes resulted in the clustering of endogenous Kv1.5 subunits at myocyte-myocyte contacts and an increase in both the maintained component of the outward K (+) current, I (Kur) (5.64 +/- 0.57 pA/pF in SAP97 myocytes vs. 3.23 +/- 0.43 pA/pF in controls) and the number of 4-aminopyridine-sensitive channels in cell-attached membrane patches. |
38(0,1,1,8) | Details |
| 19121632 | Koshida S, Kurata Y, Notsu T, Hirota Y, Kuang TY, Li P, Bahrudin U, Harada S, Miake J, Yamamoto Y, Hoshikawa Y, Igawa O, Higaki K, Soma M, Yoshida A, Ninomiya H, Shiota G, Shirayoshi Y, Hisatome I: Stabilizing effects of on Kv1.5 channel protein expressed in mammalian cells. Eur J Pharmacol. 2009 Feb 14;604(1-3):93-102. Epub 2008 Dec 16. EPA at the higher concentrations also decreased mRNA of Kv1.5 and synapse-associated protein 97 expression. EPA-induced increase of Kv1.5 channel expression and current was abolished by pretreatment with the protein transport inhibitor brefeldin A or colchicines, and by the Kv1.5 channel blocker 4-aminopyridine. |
1(0,0,0,1) | Details |