| Name | Cx36 |
|---|---|
| Synonyms | CX36; Connexin 36; Cx36; GJA 9; GJA9; Gap junction alpha 9 protein; Gap junction protein 36 KD; Gap junction protein alpha 9… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16190928 | Gajda Z, Szupera Z, Blazso G, Szente M: Quinine, a blocker of neuronal cx36 channels, suppresses seizure activity in rat neocortex in vivo. Epilepsia. 2005 Oct;46(10):1581-91. PURPOSE: The selective contribution of neuronal gap junction (GJ) communication via connexin 36 (Cx36) channels to epileptogenesis and to the maintenance and propagation of seizures was investigated in both the primary focus and the mirror focus by using pharmacologic approaches with the 4-aminopyridine in vivo epilepsy model. |
11(0,0,1,6) | Details |
| 12042356 | Maier N, Guldenagel M, Sohl G, Siegmund H, Willecke K, Draguhn A: Reduction of high-frequency network oscillations (ripples) and pathological network discharges in hippocampal slices from connexin 36-deficient mice. J Physiol. 2002 Jun 1;541(Pt 2):521-8. Moreover, epileptiform discharges elicited by 4-aminopyridine were attenuated in slices from Cx36 -/- mice. |
11(0,0,1,6) | Details |
| 12686578 | Pais I, Hormuzdi SG, Monyer H, Traub RD, Wood IC, Buhl EH, Whittington MA, LeBeau FE: Sharp wave-like activity in the hippocampus in vitro in mice lacking the gap junction protein connexin 36. J Neurophysiol. 2003 Apr;89(4):2046-54. However, bath application of the potassium channel blocker 4-aminopyridine (4-AP; 20-80 microM) produced a pattern of activity in control mice (13/16 slices), consisting of burst discharges occurring in conjunction with kainate-evoked gamma-frequency oscillations, that was similar to that seen in Cx36KO mice. |
2(0,0,0,2) | Details |
| 16690210 | Zappala A, Cicero D, Serapide MF, Paz C, Catania MV, Falchi M, Parenti R, Panto MR, La Delia F, Cicirata F: Expression of pannexin1 in the CNS of adult mouse: cellular localization and effect of 4-aminopyridine-induced seizures. Neuroscience. 2006 Aug 11;141(1):167-78. Epub 2006 May 11. This finding suggested that pannexin1 and connexin36 are involved in different functional roles or that they are expressed in different cell types and that only those expressing the Cx36 are induced to apoptosis by epileptic seizures. |
1(0,0,0,1) | Details |
| 14636335 | Gajda Z, Gyengesi E, Hermesz E, Ali KS, Szente M: Involvement of gap junctions in the manifestation and control of the duration of seizures in rats in vivo. Epilepsia. 2003 Dec;44(12):1596-600. PURPOSE: The possible role of gap junctions in the manifestation and control of the duration of seizures was tested on the 4-aminopyridine-induced epilepsy model in rats in vivo, by using electrophysiologic, pharmacologic, and molecular biologic techniques. RESULTS: After repeated seizures, the expression levels of Cx32, Cx43, and Cx36 mRNAs at the epileptic foci were increased significantly. |
1(0,0,0,1) | Details |