| Name | potassium ion channels |
|---|---|
| Synonyms | Cyclic GMP gated potassium channel; KCNA10; Kcn1; Kv1.8; Potassium ion channel; Kcn1s; Kv1.8s; Potassium ion channels |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12768777 | Yang J, Wang J: [Outward currents in isolated Deiters' cells of guinea pig cochlea]. Zhonghua Er Bi Yan Hou Ke Za Zhi. 2000 Jun;35(3):200-3. METHODS: currents in Deiters' cells in normal external solution, in external solutions with different K+ concentrations effecting on reversal potentials and outward currents, 4-aminopyridine (4-AP) and tetraethylammonium (TEA) blocking components of outward currents and kinetics of activation and inactivation of potassium ion channels were studied using the whole cell variant of the patch clamp technique. |
81(1,1,1,1) | Details |
| 20179886 | Song SL, Wei CL, Gu HG, Liu ZQ, Ren W: [The modulation of 4-aminopyridine sensitive potassium channel to bifurcation scenario of the spontaneous neural firing rhythms.]. Sheng Li Xue Bao. 2010 Feb 25;62(1):35-41. Briefly, when concentration of 4-aminopyridine (4-AP), a voltage-dependent potassium ion channels blocker, was kept at different level and extracellular Ca (2+) concentration was decreased gradually, different bifurcation scenarios of firing patterns were exhibited in an identical neural pacemaker. |
7(0,0,1,2) | Details |
| 12296855 | Qiu MR, Campbell TJ, Breit SN: A potassium ion channel is involved in cytokine production by activated human macrophages. Clin Exp Immunol. 2002 Oct;130(1):67-74. |
1(0,0,0,1) | Details |
| 18719098 | Zhan D, Fan FR, Bard AJ: The Kv channel blocker 4-aminopyridine enhances Ag+ uptake: a scanning electrochemical microscopy study of single living cells. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12118-22. Epub 2008 Aug 21. We report that silver ion (Ag (+)) uptake is enhanced by 4-aminopyridine (4-AP), a well known voltage-sensitive potassium ion channel (K (v)) blocker. |
6(0,0,1,1) | Details |
| 17014896 | Zhanping W, Xiaoyu P, Na C, Shenglan W, Bo W: Voltage-gated K+ channels are associated with cell proliferation and cell cycle of ovarian cancer cell. Gynecol Oncol. 2007 Feb;104(2):455-60. Epub 2006 Oct 2. OBJECTIVES: To study the role of Voltage-gated potassium ion channels (Kv) in cell proliferation and cell cycle of ovarian cancer cell. RESULTS: 4-Aminopyridine, an inhibitor of voltage-gated K+ channels, significantly inhibited the proliferation of A2780 cells as measured by MTT. 4-Aminopyridine also significantly affected the cell cycle, which increased the percentage of cells in G0/G1, and reduced the percentage of cells in S phase and G2/M phase. |
1(0,0,0,1) | Details |
| 12168055 | Abdul M, Hoosein N: Voltage-gated potassium ion channels in colon cancer. . Oncol Rep. 2002 Sep-Oct;9(5):961-4. PC-blockers such as glibenclamide inhibited cellular proliferation at concentrations above 50 microg/ml while tetraethylammonium and 4-aminopyridine (up to 100 microg/ml) did not have significant growth-suppressive effects. |
1(0,0,0,1) | Details |
| 10836990 | Lang R, Lee G, Liu W, Tian S, Rafi H, Orias M, Segal AS, Desir GV: KCNA10: a novel ion channel functionally related to both voltage-gated and CNG cation channels. Am J Physiol Renal Physiol. 2000 Jun;278(6):F1013-21. The channel displays an unusual inhibitor profile because, in addition to being blocked by classical K channel blockers (barium tetraethylammonium and 4-aminopyridine), it is also sensitive to inhibitors of cyclic nucleotide-gated (CNG) cation channels and pimozide). |
5(0,0,0,5) | Details |
| 15273397 | Bernard C, Anderson A, Becker A, Poolos NP, Beck H, Johnston D: Acquired dendritic channelopathy in temporal lobe epilepsy. . Science. 2004 Jul 23;305(5683):532-5. The excitability of CA1 pyramidal neuron dendrites was increased in TLE because of decreased availability of A-type potassium ion channels due to transcriptional (loss of channels) and posttranslational (increased channel phosphorylation by extracellular signal-regulated kinase) mechanisms. |
1(0,0,0,1) | Details |