| Name | CB1 receptors |
|---|---|
| Synonyms | Brain cannabinoid receptor 1; CNR1; CANN 6; CANN6; CB R; CB1; CB1 receptor; CB1A… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16474412 | Romano MR, Lograno MD: Cannabinoid agonists induce relaxation in the bovine ophthalmic artery: evidences for CB1 receptors, and channels. Br J Pharmacol. 2006 Apr;147(8):917-25. Relaxations to and WIN55212-2 were inhibited by iberiotoxin (IbTX, 200 nM), a blocker of large conductance, Ca2+-activated K+ channel (BK (Ca)), and by 4-aminopyridine (4-AP; 1 mM), a blocker of delayed rectifier K+ channel, whereas the blockade of K (ATP) channels by glibenclamide (5 microM) and of small conductance Ca2+-activated K+ channels (SK (Ca)) by apamin (100 nM) did not produce any effects. |
3(0,0,0,3) | Details |
| 14975678 | Dougalis A, Lees G, Ganellin CR: The sleep lipid oleamide may represent an endogenous anticonvulsant: an in vitro comparative study in the 4-aminopyridine rat brain-slice model. Neuropharmacology. 2004 Mar;46(4):541-54. The weak effects of cOA seem independent of cannabinoid (CB1) receptors. |
1(0,0,0,1) | Details |
| 17606273 | Mato S, Lafourcade M, Robbe D, Bakiri Y, Manzoni OJ: Role of the cyclic-AMP/PKA cascade and of P/Q-type Ca++ channels in endocannabinoid-mediated long-term depression in the nucleus accumbens. Neuropharmacology. 2008 Jan;54(1):87-94. Epub 2007 May 5. At these synapses exogenous cannabinoid receptor 1 (CB1R) agonists reversibly inhibit excitatory transmission, and the sustained release of endogenous cannabinoids (eCB) following prolonged cortical stimulation leads to long-term depression (LTD). |
1(0,0,0,1) | Details |
| 15901756 | Tang SL, Tran V, Wagner EJ: Sex differences in the cannabinoid modulation of an A-type K+ current in neurons of the mammalian hypothalamus. J Neurophysiol. 2005 Oct;94(4):2983-6. Epub 2005 May 18. Forty percent of guinea pig ARC neurons exhibited a transient outward current that was antagonized by high (mM) concentrations of 4-aminopyridine and (100 nM) rHeteropodatoxin-2. The CB1 receptor antagonist AM251 (1 microM) reversed this action. |
1(0,0,0,1) | Details |
| 12782184 | Wang SJ: Cannabinoid CB1 receptor-mediated inhibition of release from rat hippocampal synaptosomes. Eur J Pharmacol. 2003 May 23;469(1-3):47-55. Using synaptosomal preparation, I show here that 2,3-dihydro-5-methyl-3-(4-morpholinyl-methyl)-pyrrolo-1,4-benzoxazin-6-yl- 1-naphthalenylmethanone (WIN 55212-2) strongly depressed 4-aminopyridine-evoked release in a concentration-dependent manner, and this effect was reversed by the selective cannabinoid CB (1) receptor antagonist 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazo le-3-carboxamide (AM 281). |
1(0,0,0,1) | Details |
| 10729327 | Hoffman AF, Lupica CR: Mechanisms of cannabinoid inhibition of (A) synaptic transmission in the hippocampus. J Neurosci. 2000 Apr 1;20(7):2470-9. The presynaptic effect of WIN 55,212-2 was also investigated using the potassium channel blockers barium and 4-aminopyridine. |
0(0,0,0,0) | Details |
| 15821751 | O'Sullivan SE, Kendall DA, Randall MD: The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid Br J Pharmacol. 2005 Jun;145(4):514-26. 1 Delta9-tetrahydrocannabinol (THC) produces varying effects in mesenteric arteries: vasorelaxation (third-order branches, G3), modest vasorelaxation (G2), no effect (G1) and vasoconstriction (the superior mesenteric artery, G0). 2 In G3, vasorelaxation to THC was inhibited by pertussis toxin, but was unaffected by the CB1 receptor antagonist, AM251 (1 microM), incubation with the TRPV1 receptor agonist (10 microM, 1 h), the TRPV1 receptor antagonist capsazepine (10 microM) or de-endothelialisation. 3 In G3, vasorelaxation to THC was inhibited by high K+ buffer, and by the following K+ channel inhibitors: charybdotoxin (100 nM), apamin (500 nM) and barium (30 microM), but not by 4-aminopyridine, glibenclamide or tertiapin. 4 In G3, THC (10 and 100 microM) inhibited the contractile response to Ca2+ in a Ca2+-free, high potassium buffer, indicating that THC blocks Ca2+ influx. 5 In G0, the vasoconstrictor responses to THC were inhibited by de-endothelialisation and SR141716A (100 nM), but not by the endothelin (ET (A)) receptor antagonist FR139317 (1 microM).THC (1 and 10 microM) antagonised vasorelaxation to in G3 but not G0. |
0(0,0,0,0) | Details |
| 12913062 | Souza HC, Salgado HC, Ballejo G, Salgado MC: SR141716A-sensitive enhancement of ET-1 hypotensive effect by chronic NOS inhibition. Hypertension. 2003 Oct;42(4):802-5. Epub 2003 Aug 11. The enhanced ET-1 hypotensive effect in L-NAME-treated rats was abolished by the ETB receptor antagonist BQ-788 but was unaltered by the cyclooxygenase inhibitor diclofenac, the cytochrome P450 inhibitor fluconazole, or the potassium channel blockers apamin, glibenclamide, tetraethylammonium, and 4-aminopyridine. |
0(0,0,0,0) | Details |
| 16806307 | Schoffelmeer AN, Hogenboom F, Wardeh G, De Vries TJ: Interactions between CB1 cannabinoid and mu opioid receptors mediating inhibition of neurotransmitter release in rat nucleus accumbens core. Neuropharmacology. 2006 Sep;51(4):773-81. Epub 2006 Jun 30. To that end, receptor-mediated inhibition of depolarization (4-aminopyridine)-induced [3H] release and (NMDA) receptor-stimulated [14C] and [3H] release was studied in superfused NAc core slices. |
9(0,0,0,9) | Details |
| 15034129 | Daniel H, Rancillac A, Crepel F: Mechanisms underlying cannabinoid inhibition of presynaptic Ca2+ influx at parallel fibre synapses of the rat cerebellum. J Physiol. 2004 May 15;557(Pt 1):159-74. Epub 2004 Mar 19. This depression involves the activation of presynaptic 4-aminopyridine-sensitive K (+) channels by CB1 receptors, which in turn inhibits presynaptic Ca (2+) influx controlling release at these synapses. |
65(0,2,2,5) | Details |
| 11744755 | Daniel H, Crepel F: Control of Ca (2+) influx by cannabinoid and metabotropic glutamate receptors in rat cerebellar cortex requires K (+) channels. J Physiol. 2001 Dec 15;537(Pt 3):793-800. In the rodent cerebellum, both presynaptic CB1 cannabinoid receptors and presynaptic mGluR4 metabotropic glutamate receptors acutely depress excitatory synaptic transmission at parallel fibre-Purkinje cell synapses. |
5(0,0,0,5) | Details |
| 11150326 | Robbe D, Alonso G, Duchamp F, Bockaert J, Manzoni OJ: Localization and mechanisms of action of cannabinoid receptors at the glutamatergic synapses of the mouse nucleus accumbens. J Neurosci. 2001 Jan 1;21(1):109-16. Despite the role of excitatory transmission to the nucleus accumbens (NAc) in the actions of most drugs of abuse, the presence and functions of cannabinoid receptors (CB1) on the glutamatergic cortical afferents to the NAc have never been explored. The K (+) channel blockers 4-aminopyridine (100 micrometer) and BaCl (2) (300 micrometer) each reduced by 40-50% the inhibitory actions of WIN-2, and their effects were additive. |
4(0,0,0,4) | Details |