| Name | KCNA1 |
|---|---|
| Synonyms | AEMK; EA1; HBK 1; HBK1; HUK 1; HUK1; HUKI; KCNA 1… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18365869 | Rampino T, Gregorini M, Guidetti C, Broggini M, Marchini S, Bonomi R, Maggio M, Roscini E, Soccio G, Tiboldo R, Dal Canton A: KCNA1 and TRPC6 ion channels and NHE1 exchanger operate the biological outcome of HGF/scatter factor in renal tubular cells. Growth Factors. 2007 Dec;25(6):382-91. To investigate whether KCNA1, TRPC6, NHE1 mediate the changes induced by HGF in HK2, we studied the effects of their inhibitors: 4-aminopyridine, charybdotoxin, dendrotoxin K inhibitors of KCNA1, lanthanum, N-(p-amylcinnamoyl) inhibitors of TRPC6, 5-(N-ethyl-N-isopropyl) amiloride, cariporide inhibitors of NHE1. |
84(1,1,1,4) | Details |
| 15673604 | Barfield JP, Yeung CH, Cooper TG: The effects of putative K+ channel blockers on volume regulation of murine spermatozoa. Biol Reprod. 2005 May;72(5):1275-81. Epub 2005 Jan 26. The presence of quinine (0.8 mM), cadmium (0.2 mM), flecainide (100 microM), 4-aminopyridine (4 mM), barium (1 mM), clofilium (10 microM), and phrixotoxin (100 nM) for 75 min resulted in significantly higher forward scatter values than sperm incubated in medium without an inhibitor. These results imply that channels potentially involved in volume regulation of murine spermatozoa include the voltage-dependent Kv1.4 (also known as KCNA1), Kv1.5 (KCNA5), Kv4.1 (KCND1), Kv4.2 (KCND2), Kv4.3 (KCND3), mink (KCNE1), and acid-sensitive TASK2 (KCNK5) and TASK3 (KCNK9). |
1(0,0,0,1) | Details |