| Name | KCa3.1 |
|---|---|
| Synonyms | IK1; IKCA 1; IKCA1; Intermediate conductance calcium activated potassium channel protein 4; KCA 4; KCA4; KCNN 4; KCNN4… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11228861 | Wu MH, Su MJ, Sun SS: Electrophysiological profile after inward rectifier K channel blockade by barium in isolated rabbit hearts. Europace. 1999 Apr;1(2):85-95. AIMS: The aims of this study were to define the changes of cardiac conduction properties after selective IK1 blockade in isolated hearts. Such a response was neither observed with 4-aminopyridine (Ito blocker) nor with d-sotalol (IK blocker). |
5(0,0,0,5) | Details |
| 12588897 | Marcotti W, Johnson SL, Holley MC, Kros CJ: Developmental changes in the expression of currents of embryonic, neonatal and mature mouse inner hair cells. J Physiol. 2003 Apr 15;548(Pt 2):383-400. Epub 2003 Feb 14. As early as embryonic day 14.5 (E14.5) newly differentiated IHCs express a very small outward K+ current that is largely insensitive to 4-aminopyridine (4-AP). One day later the inward rectifier, IK1, is first observed. |
2(0,0,0,2) | Details |
| 10803358 | Aomine M, Yamato T: Electrophysiological properties of ventricular muscle obtained from spontaneously diabetic mice. Exp Anim. 2000 Jan;49(1):23-33. A blocker of transient outward current (I (to)), 4-aminopyridine, significantly prolonged the APD of the B6 mice, but failed to prolong it in the KK mice, suggesting that Ito in the diabetic mice is very small. These suggest a decrease in a time-independent K+ current (IK1) in the KK mice. |
2(0,0,0,2) | Details |
| 12879867 | Cho HS, Takano M, Noma A: The electrophysiological properties of spontaneously beating pacemaker cells isolated from mouse sinoatrial node. J Physiol. 2003 Jul 1;550(Pt 1):169-80. The major repolarizing current was the slowly inactivating, 4-aminopyridine-insensitive outward current. The inward-rectifier K+ current (IK1) was also recorded in spontaneously beating myocytes. |
2(0,0,0,2) | Details |
| 16763288 | Dong H, Smith A, Hovaida M, Chow JY: Role of Ca2+-activated K+ channels in duodenal mucosal ion transport and secretion. Am J Physiol Gastrointest Liver Physiol. 2006 Dec;291(6):G1120-8. Epub 2006 Jun 8. Finally, the molecular identity of IK (Ca) channels was verified as KCNN4 (SK4) in freshly isolated murine duodenal mucosae by RT-PCR and Western blotting. Tetraethylammonium, 4-aminopyridine, and BaCl (2) failed to inhibit CCh-induced I (sc) and DMBS. |
1(0,0,0,1) | Details |
| 17687001 | Bai X, Ma J, Pan Z, Song YH, Freyberg S, Yan Y, Vykoukal D, Alt E: Electrophysiological properties of human adipose tissue-derived stem cells. Am J Physiol Cell Physiol. 2007 Nov;293(5):C1539-50. Epub 2007 Aug 8. RT-PCR results confirmed the presence of ion channels at the mRNA level: Kv1.1, Kv2.1, Kv1.5, Kv7.3, Kv11.1, and hEAG1, possibly encoding I (KDR); MaxiK, KCNN3, and KCNN4 for I (KCa); Kv1.4, Kv4.1, Kv4.2, and Kv4.3 for I (to) and hNE-Na for I (Na.TTX). The I (KDR) was inhibited by tetraethyl ammonium (TEA) and 4-aminopyridine (4-AP), which significantly reduced the proliferation of hASCs in a dose-dependent manner (P < 0.05), as suggested by bromodeoxyurindine (BrdU) incorporation. |
1(0,0,0,1) | Details |
| 16876113 | Deng XL, Sun HY, Lau CP, Li GR: Properties of ion channels in rabbit mesenchymal stem cells from bone marrow. Biochem Biophys Res Commun. 2006 Sep 15;348(1):301-9. Epub 2006 Jul 20. IK (DR) exhibited a slow inactivation, "U-shaped" voltage-dependent inactivation, and slow recovery from inactivation, and the current was inhibited by tetraethylammonium or 4-aminopyridine. RT-PCR revealed the molecular identities for the functional ionic currents, including Kir1.1 (possibly responsible for I (Kir)), KCa1.1 and KCa3.1 (possibly responsible for I (KCa)), and Kv1.2, Kv2.1, and Kv2.2 (possibly responsible for IK (DR)). |
1(0,0,0,1) | Details |
| 10672450 | Casis O, Gallego M, Iriarte M, Sanchez-Chapula JA: Effects of diabetic cardiomyopathy on regional electrophysiologic characteristics of rat ventricle. Diabetologia. 2000 Jan;43(1):101-9. METHODS: We studied the effects of streptozotocin-induced diabetes on the current density of the repolarising currents It (o), IK, Iss and IK1 in enzymatically isolated myocytes from three different regions of rat heart: total right ventricle, subepicardium at the apex of the left ventricle and subendocardium at the base of the left ventricle. |
1(0,0,0,1) | Details |