| Name | mGluR5 |
|---|---|
| Synonyms | GPRC1E; GRM 5; GRM5; MGLUR 5; MGLUR5; MGLUR5A; MGLUR5B; Metabotropic glutamate receptor 5… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11102477 | Ango F, Pin JP, Tu JC, Xiao B, Worley PF, Bockaert J, Fagni L: Dendritic and axonal targeting of type 5 metabotropic glutamate receptor is regulated by homer1 proteins and neuronal excitation. J Neurosci. 2000 Dec 1;20(23):8710-6. Depolarization of the neurons with a mixture of ionotropic glutamate receptor agonists, and kainate, or potassium channel blockers, tetraethylammonium and 4-aminopyridine, induced transient expression of endogenous Homer1a and persistent neuritic localization of transfected mGluR5 even long after degradation of Homer1a. |
37(0,1,1,7) | Details |
| 12364493 | Lee AC, Wong RK, Chuang SC, Shin HS, Bianchi R: Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slices. J Neurophysiol. 2002 Oct;88(4):1625-33. Addition of 4-aminopyridine (4-AP; 100 microM) prolonged these bursts to 0.7-2 s. The mGluR1 antagonist (S)-(+)-alpha-amino-4-carboxy-2-methylbenzeneacetic acid (LY 367385; 25-100 microM) and the mGluR5 antagonist 2-methyl-6-(phenylethynyl) (MPEP; 10-50 microM), applied separately, significantly reduced the duration of the synchronized discharges. |
4(0,0,0,4) | Details |
| 18675825 | Witkin JM, Baez M, Yu J, Eiler WJ 2nd: mGlu5 receptor deletion does not confer seizure protection to mice. Life Sci. 2008 Aug 29;83(9-10):377-80. Epub 2008 Jul 15. Metabotropic glutamate mGlu5 receptors have been implicated in the regulation of seizures and have been suggested as a target against which discovery of novel anticonvulsants may be possible. Chemically induced seizures induced by a variety of mechanisms including pentylenetetrazole, cocaine, kainic acid, 4-aminopyridine, strychnine, and did not differentially increase clonic, clonic/tonic, or lethality in WT vs. mGlu5 receptor KO mice. |
2(0,0,0,2) | Details |
| 12629172 | Gebremedhin D, Yamaura K, Zhang C, Bylund J, Koehler RC, Harder DR: Metabotropic glutamate receptor activation enhances the activities of two types of Ca2+-activated k+ channels in rat hippocampal astrocytes. J Neurosci. 2003 Mar 1;23(5):1678-87. Patch-clamp analysis of K (+) channel currents in cultured astrocytes identified the existence of 71 +/- 6 and 161 +/- 11 pS single-channel K (+) currents that were sensitive to changes in voltage and [Ca (2+)](i) and blocked by external TEA but not by charybdotoxin, iberiotoxin, apamin, or 4-aminopyridine. Expression of the metabotropic glutamate receptor (mGluR) subtypes mGluR1 and mGluR5 and the ionotropic glutamate receptor (iGluR) subtypes iGluR1 and iGluR4 were detected by RT-PCR and immunofluorescence analysis in cultured astrocytes. |
1(0,0,0,1) | Details |
| 18538357 | Salah A, Perkins KL: Effects of subtype-selective group I mGluR antagonists on synchronous activity induced by 4-aminopyridine/CGP 55845 in adult guinea pig hippocampal slices. Neuropharmacology. 2008 Jul;55(1):47-54. Epub 2008 Apr 23. Here we tested the effects of the group I metabotropic glutamate receptor (mGluR) subtype-selective antagonists LY 367385 (mGlu1, 100 microM), MPEP (mGlu5, 10 microM), and MTEP (mGlu5, 500 nM) on this synchronous activity. |
2(0,0,0,2) | Details |
| 14623765 | White AM, Kylanpaa RA, Christie LA, McIntosh SJ, Irving AJ, Platt B: Presynaptic group I metabotropic glutamate receptors modulate synaptic transmission in the rat superior colliculus via 4-AP sensitive K (+) channels. Br J Pharmacol. 2003 Dec;140(8):1421-33. Epub 2003 Nov 17. The K+ channel antagonist 4-aminopyridine (4-AP, 50-100 microm) converted the inhibitory effect of into facilitation. The putative mGluR5-specific agonist (RS)-2-chloro-5-hydroxyphenylglycine (CHPG, 500 microm) also inhibited EPSPs. |
1(0,0,0,1) | Details |