| Name | KCa1.1 |
|---|---|
| Synonyms | BK channel; BKCA alpha; BKCAa; BKCAalpha; BKTM; Calcium activated potassium channel alpha subunit 1; Calcium activated potassium channel subunit alpha 1; Drosophila slowpoke like… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11579156 | Armstrong CE, Roberts WM: Rapidly inactivating and non-inactivating -activated currents in frog saccular hair cells. J Physiol. 2001 Oct 1;536(Pt 1):49-65. Inactivation of I (transient) could be removed by extracellular papain and could later be restored by intracellular application of the 'ball' domain of the auxiliary subunit (beta2) thought to mediate BK channel inactivation in rat chromaffin cells. After blocking voltage-dependent K (+) (K (V)) currents with 4-aminopyridine (4-AP) an outward current containing inactivating (I (transient)) and non-inactivating (I (steady)) components remained. 2. |
1(0,0,0,1) | Details |
| 20157397 | Kim JK, Han WH, Lee MY, Myung SC, Kim SC, Kim MK: relaxes rabbit seminal vesicle by calcium channel inhibition. . Korean J Physiol Pharmacol. 2008 Apr;12(2):73-7. Epub 2008 Apr 30. Single channel data (of inside-out and attached configurations) of BK channel activity were also hardly affected by (10 microM). Various K (+) channel blockers, such as tetraethylammonium (TEA; 10 mM), iberiotoxin (0.1 microM), 4-aminopyridine (4-AP, 10 microM), or glibenclamide (10 microM) rarely affected these relaxations. |
1(0,0,0,1) | Details |
| 17435380 | Matsushita M, Tanaka Y, Koike K: Studies on the mechanisms underlying beta-adrenoceptor-mediated relaxation of rat abdominal aorta. J Smooth Muscle Res. 2006 Dec;42(6):217-25. Isoprenaline-induced relaxation in the presence of SQ 22,536 was significantly diminished by iberiotoxin (IbTx, 0.1 microM), but was not affected by 4-aminopyridine (4-AP, 3 mM). These results suggest that in rat abdominal aortic smooth muscle: 1) both beta (1)-/beta (2)-AR- and beta (3)-AR-mediated relaxations substantially involve cAMP-independent mechanisms; 2) beta (1)-/beta (2)-AR-mediated, cAMP-independent relaxant mechanisms are partly attributed to the large-conductance, Ca (2+)-sensitive K (+) (MaxiK, BK) channel whereas beta (3)-AR-mediated relaxant mechanisms are attributed to K (v) channel. |
1(0,0,0,1) | Details |
| 16394199 | Tanaka Y, Tang G, Takizawa K, Otsuka K, Eghbali M, Song M, Nishimaru K, Shigenobu K, Koike K, Stefani E, Toro L: Kv channels contribute to - and atrial natriuretic peptide-induced relaxation of a rat conduit artery. J Pharmacol Exp Ther. 2006 Apr;317(1):341-54. Epub 2006 Jan 4. The role of K (+) channels in (NO)-induced vasorelaxation has been largely investigated in resistance vessels where iberiotoxin-sensitive MaxiK channels play a predominant role. Aortic relaxations were strongly diminished by 4-aminopyridine (4-AP) (> or =5 x 10 (-3) M) or by tetraethylammonium (> 2 x 10 (-3) M) at concentrations known to inhibit voltage-dependent K (+) (K (v)) 2-type channels but not by other K (+) channel inhibitors, glibenclamide, apamin, charybdotoxin, tertiapin, or E-4031 N-[4-[[1-[2-(6-methyl-2-pyridinyl) ethyl]-4-piperidinyl-] carbonyl] phenyl] me thanesulfonamide dihydrochloride). |
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| 17468198 | Bukiya AN, Liu J, Toro L, Dopico AM: Beta1 (KCNMB1) subunits mediate activation of large-conductance Ca2+-activated K+ channels and dilation in small, resistance-size arteries. Mol Pharmacol. 2007 Aug;72(2):359-69. Epub 2007 Apr 27. This study pinpoints the BK beta1 subunit as the molecule that senses LC, which results in myocyte BK channel activation and, thus, endothelial-independent relaxation of small, resistance-size arteries. LC action is independent of endothelial integrity, prevented by 55 nM iberiotoxin, and unmodified by 0.8 mM 4-aminopyridine, indicating that LC causes vasodilation via myocyte BK channels. |
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| 14561831 | Faber ES, Sah P: Ca2+-activated K+ (BK) channel inactivation contributes to spike broadening during repetitive firing in the rat lateral amygdala. J Physiol. 2003 Oct 15;552(Pt 2):483-97. In contrast, broadening is not blocked by high concentrations of 4-aminopyridine (4-AP) or alpha-dendrotoxin. |
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| 17687001 | Bai X, Ma J, Pan Z, Song YH, Freyberg S, Yan Y, Vykoukal D, Alt E: Electrophysiological properties of human adipose tissue-derived stem cells. Am J Physiol Cell Physiol. 2007 Nov;293(5):C1539-50. Epub 2007 Aug 8. RT-PCR results confirmed the presence of ion channels at the mRNA level: Kv1.1, Kv2.1, Kv1.5, Kv7.3, Kv11.1, and hEAG1, possibly encoding I (KDR); MaxiK, KCNN3, and KCNN4 for I (KCa); Kv1.4, Kv4.1, Kv4.2, and Kv4.3 for I (to) and hNE-Na for I (Na.TTX). The I (KDR) was inhibited by tetraethyl ammonium (TEA) and 4-aminopyridine (4-AP), which significantly reduced the proliferation of hASCs in a dose-dependent manner (P < 0.05), as suggested by bromodeoxyurindine (BrdU) incorporation. |
1(0,0,0,1) | Details |
| 12377604 | Chen M, Sun HY, Wang Y, Gao TM: Protection of potassium channel inhibitors against hypoxia/reoxygenation-induced death of cultured hippocampal neurons. Di Yi Jun Yi Da Xue Xue Bao. 2002 Oct;22(10):872-4. CONCLUSION: Following hypoxia/reoxygenation, enhanced activity of potassium channel, especially BK channel, may induce neuron death. However, A-type potassium channel inhibitor 4-aminopyridine presented no protection against neuron death (P> 0.05). |
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| 11736694 | Imai T, Okamoto T, Yamamoto Y, Tanaka H, Koike K, Shigenobu K, Tanaka Y: Effects of different types of K+ channel modulators on the spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle. Acta Physiol Scand. 2001 Nov;173(3):323-33. Iberiotoxin (50 nM), a selective blocker of large-conductance, voltage-gated Ca2+-activated K+ (K (Ca)) (BK) channel, dramatically increased both contraction amplitude and frequency whereas NS-1619 (30 microM), which increases BK channel activity, decreased them. A blocker of voltage-gated K+ (Kv) channel, 4-aminopyridine (100 microM), significantly increased contraction frequency. |
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| 16876113 | Deng XL, Sun HY, Lau CP, Li GR: Properties of ion channels in rabbit mesenchymal stem cells from bone marrow. Biochem Biophys Res Commun. 2006 Sep 15;348(1):301-9. Epub 2006 Jul 20. IK (DR) exhibited a slow inactivation, "U-shaped" voltage-dependent inactivation, and slow recovery from inactivation, and the current was inhibited by tetraethylammonium or 4-aminopyridine. RT-PCR revealed the molecular identities for the functional ionic currents, including Kir1.1 (possibly responsible for I (Kir)), KCa1.1 and KCa3.1 (possibly responsible for I (KCa)), and Kv1.2, Kv2.1, and Kv2.2 (possibly responsible for IK (DR)). |
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| 17980032 | Smith RC, McClure MC, Smith MA, Abel PW, Bradley ME: The role of voltage-gated potassium channels in the regulation of mouse uterine contractility. Reprod Biol Endocrinol. 2007 Nov 2;5:41. RESULTS: The Kv channel blocker 4-aminopyridine (4-AP) caused contractions in nonpregnant mouse myometrium (EC50 = 54 micromolar, maximal effect at 300 micromolar) but this effect disappeared in pregnant mice; similarly, the Kv4.2/Kv4.3 blocker phrixotoxin-2 caused contractions in nonpregnant, but not pregnant, myometrium. |
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| 11294244 | Franciolini F, Hogg R, Catacuzzeno L, Petris A, Trequattrini C, Adams DJ: Large-conductance -activated channels in neonatal rat intracardiac ganglion neurons. Pflugers Arch. 2001 Feb;441(5):629-38. The BK channel was inhibited reversibly by external tetraethylammonium (TEA) ions, charybdotoxin, and quinine and was resistant to block by 4-aminopyridine and apamin. |
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| 17624594 | Han X, Wang F, Yao W, Xing H, Weng D, Song X, Chen G, Xi L, Zhu T, Zhou J, Xu G, Wang S, Meng L, Iadecola C, Wang G, Ma D: Heat shock proteins and p53 play a critical role in K+ channel-mediated tumor cell proliferation and apoptosis. Apoptosis. 2007 Oct;12(10):1837-46. The patch-clamping study using the whole-cell mode revealed two components of voltage-gated outward K+ currents: one is sensitive to either tetraethylammonium (TEA) or tetrandrine (Tet), a maxi-conductance Ca2+-activated K+ (BK) channel blocker, and the other is sensitive to 4-aminopyridine (4-AP), a delayed rectifier K+ channel blocker. |
32(0,1,1,2) | Details |
| 11770009 | Yamaki F, Kaga M, Horinouchi T, Tanaka H, Koike K, Shigenobu K, Toro L, Tanaka Y: MaxiK channel-mediated relaxation of guinea-pig aorta following stimulation of IP receptor with beraprost via cyclic AMP-dependent and -independent mechanisms. Naunyn Schmiedebergs Arch Pharmacol. 2001 Dec;364(6):538-50. The relaxation induced by beraprost was not significantly affected by other K+ channel blockers glibenclamide (10 (-6) M) or Ba2+ (10 (-5) M), but was slightly attenuated by 4-aminopyridine (10 (-4) M). |
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| 18942098 | Hu H, He ML, Tao R, Sun HY, Hu R, Zang WJ, Yuan BX, Lau CP, Tse HF, Li GR: Characterization of ion channels in human preadipocytes. J Cell Physiol. 2009 Feb;218(2):427-35. It was found that a 4-aminopyridine- (4-AP) sensitive transient outward K (+) current (I (to)) was present in a small population of (32.0%) cells, and an outward "noisy" big conductance Ca (2+)-activated K (+) current (I (KCa)) was present in most (92.7%) preadipocytes. RT-PCR and Western blot revealed the molecular identities (i.e., KCa1.1 and Kv4.2) of the functional ionic currents I (KCa) and I (to). |
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| 17060504 | Xu H, Jackson WF, Fink GD, Galligan JJ: Activation of channels by tempol in arterial smooth muscle cells from normotensive and -salt hypertensive rats. Hypertension. 2006 Dec;48(6):1080-7. Epub 2006 Oct 23. Western blot and immunocytochemical studies revealed that BK channel alpha-subunit expression was increased in DOCA-salt MA compared with sham MA. Iberiotoxin but not 4-aminopyridine blocked the I (o) activated by tempol. |
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| 15749932 | Li GR, Sun H, Deng X, Lau CP: Characterization of ionic currents in human mesenchymal stem cells from bone marrow. Stem Cells. 2005 Mar;23(3):371-82. Three types of outward currents were found in hMSCs, including a noise-like rapidly activating outward current inhibited by the large conductance Ca (2+)-activated K (+) channel (I (KCa)) blocker iberiotoxin, a transient outward K (+) current (I (to)) suppressed by 4-aminopyridine (4-AP), and a delayed rectifier K (+) current (IK (DR))-like ether-a-go-go (eag) K (+) channel. Moreover, RT-PCR revealed the molecular evidence of high levels of mRNA for the functional ionic currents, including human MaxiK for I (KCa), Kv4.2 and Kv1.4 for I (to), heag1 for IK (DR), hNE-Na for I (Na.TTX), and CACNAIC for I (Ca.L). |
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| 11882617 | Lauterbach B, Barbosa-Sicard E, Wang MH, Honeck H, Kargel E, Theuer J, Schwartzman ML, Haller H, Luft FC, Gollasch M, Schunck WH: Cytochrome P450-dependent metabolites are novel BK channel activators. Hypertension. 2002 Feb;39(2 Pt 2):609-13. The effect of 17 (R),18 (S)-EETeTr was blocked by tetraethylammonium but not by 4-aminopyridine. |
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| 11739569 | Hu H, Shao LR, Chavoshy S, Gu N, Trieb M, Behrens R, Laake P, Pongs O, Knaus HG, Ottersen OP, Storm JF: Presynaptic Ca2+-activated K+ channels in glutamatergic hippocampal terminals and their role in spike repolarization and regulation of transmitter release. J Neurosci. 2001 Dec 15;21(24):9585-97. Double-labeling immunogold analysis with BK channel and glutamate receptor antibodies indicated that BK channels are targeted to the presynaptic membrane facing the synaptic cleft in terminals of Schaffer collaterals in stratum radiatum. This was observed in the presence of 4-aminopyridine (4-AP, 40-100 microm), which broadened the presynaptic compound action potential. |
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| 17525238 | Park KS, Jung KH, Kim SH, Kim KS, Choi MR, Kim Y, Chai YG: Functional expression of ion channels in mesenchymal stem cells derived from umbilical cord vein. Stem Cells. 2007 Aug;25(8):2044-52. Epub 2007 May 24. In the RT-PCR analysis, Kv1.1, Kv4.2, Kv1.4, Kir2.1, heag1, MaxiK, hNE-Na, and TWIK-1 were detected. I (to) was inhibited by 4-aminopyridine. |
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