Protein Information

Name GABA transporter
Synonyms GABA transporter; GABATHG; GABATR; GABT 1; GABT1; GAT 1; GAT1; Gamma aminobutyric acid transporter…

Compound Information

Name 4-aminopyridine
CAS 4-pyridinamine

Reference List

PubMed Abstract RScore(About this table)
11821145 Storchak LG, Linetska MV, Himmelreich NH: Does extracellular calcium determine what pool of GABA is the target for alpha-latrotoxin?. Neurochem Int. 2002 Apr;40(5):387-95.

We also compared the effect of the GABA transporter inhibitors on depolarisation-evoked and alpha-latrotoxin-evoked [(3) H] GABA release using as depolarising agents 4-aminopyridine and high KCl in the Ca (2+)-containing and in Ca (2+)-free medium, respectively.
33(0,1,1,3) Details
12916239 Linets'ka MV, Storchak LH, Himmelreich NH: [Effect of synaptosomal cytosolic [3H] GABA pool depletion on secretory ability of alpha-latrotoxin]. Ukr Biokhim Zh. 2002 May-Jun;74(3):65-72.

The main aim of the study was to elucidate whether the binding of alpha-latrotoxin to different types of receptors led to [3H] GABA secretion from one pool or in each case the source of neurotransmitter differs: in the presence of Ca2+ exocytosis is induced, while in the absence of Ca (2+)--outflow by mobile membrane GABA transporter from cytoplasm.
Depolarization was stimulated by 4-aminopyridine in the Ca (2+)-containing saline and high KCl in Ca (2+)-free medium.
2(0,0,0,2) Details