| Name | bcl 2 |
|---|---|
| Synonyms | Apoptosis regulator Bcl 2; B cell CLL/lymphoma 2; B cell lymphoma protein 2 alpha; B cell lymphoma protein 2 alpha isoform; BCL2; Bcl 2; B cell CLL/lymphoma 2s; B cell lymphoma protein 2 alphas… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11401838 | Ekhterae D, Platoshyn O, Krick S, Yu Y, McDaniel SS, Yuan JX: Bcl-2 decreases voltage-gated K+ channel activity and enhances survival in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2001 Jul;281(1):C157-65. Blockade of Kv channels in control cells (-bcl-2) by 4-aminopyridine also inhibited the ST-induced increase in I (Kv) and apoptosis. |
38(0,1,1,8) | Details |
| 10556359 | Wang L, Zhou P, Craig RW, Lu L: Protection from cell death by mcl-1 is mediated by membrane hyperpolarization induced by K (+) channel activation. J Membr Biol. 1999 Nov 15;172(2):113-20. Mcl-1, a member of the Bcl-2 family, has been identified as an inhibitor of apoptosis induced by anticancer agents and radiation in myeloblastic leukemia cells. Suppression of K (+) channel activity by 4-aminopyridine (4-AP) before etoposide treatment significantly reduced the viability of mcl-1 transfected cells to 49.0 +/- 4.6%. |
1(0,0,0,1) | Details |
| 19643095 | Smith AJ, Tauskela JS, Stone TW, Smith RA: Preconditioning with 4-aminopyridine protects cerebellar granule neurons against excitotoxicity. Brain Res. 2009 Oct 19;1294:165-75. Epub 2009 Jul 28. |
0(0,0,0,0) | Details |