| Name | IL 1beta |
|---|---|
| Synonyms | Catabolin; IL 1; IL 1 beta; IL 1B; IL1 beta; IL1B; IL1F2; Interleukin 1… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10800933 | Morgan AC, Chang HY, Liu JS, Hua LL, Lee SC: High extracellular modulates synthase expression in human astrocytes. J Neurochem. 2000 May;74(5):1903-12. In addition, several potassium channel inhibitors such as CsCl, tetraethylammonium, and 4-aminopyridine as well as nigericin inhibited astrocyte iNOS expression induced by IL-1/IFNgamma. |
82(1,1,1,2) | Details |
| 16777343 | Tabarean IV, Korn H, Bartfai T: Interleukin-1beta induces hyperpolarization and modulates synaptic inhibition in preoptic and anterior hypothalamic neurons. Neuroscience. 2006 Sep 15;141(4):1685-95. Epub 2006 Jun 13. The latter effect may account in part for the increased spontaneous inhibitory postsynaptic current frequency as suggested by experiments with the A-type K (+) channel blockers 4-aminopyridine. |
7(0,0,0,7) | Details |
| 17093087 | Franciosi S, Ryu JK, Choi HB, Radov L, Kim SU, McLarnon JG: Broad-spectrum effects of 4-aminopyridine to modulate amyloid beta1-42-induced cell signaling and functional responses in human microglia. J Neurosci. 2006 Nov 8;26(45):11652-64. Abeta (1-42) also induced the expression and production of the pro-inflammatory cytokines interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha, the chemokine IL-8, and the enzyme cyclooxygenase-2; 4-AP was effective in reducing all of these pro-inflammatory mediators. |
1(0,0,0,1) | Details |
| 16041798 | Zhu P, Genc A, Zhang X, Zhang J, Bazan NG, Chen C: Heterogeneous expression and regulation of hippocampal prostaglandin E2 receptors. J Neurosci Res. 2005 Sep 15;81(6):817-26. It appeared that interleukin-1 beta increased the expression of EP 2 and EP 4 mRNAs. A blockade of synaptic transmission with either tetrodotoxin or MK-801 plus 6,7-dinitroquinoxaline-2,3-dione (DNQX) for 6 hr increased EP 3 and EP 4 mRNA, whereas high K (+) (90 mM) or 4-aminopyridine enhanced EP 2 and EP 4. |
1(0,0,0,1) | Details |
| 18596165 | Galic MA, Riazi K, Heida JG, Mouihate A, Fournier NM, Spencer SJ, Kalynchuk LE, Teskey GC, Pittman QJ: Postnatal inflammation increases seizure susceptibility in adult rats. J Neurosci. 2008 Jul 2;28(27):6904-13. Three weeks later, extracellular recordings from hippocampal slices revealed enhanced field EPSP slopes after Schaffer collateral stimulation and increased epileptiform burst-firing activity in CA1 after 4-aminopyridine application. |
0(0,0,0,0) | Details |