Protein Information

Name CD1
Synonyms CD1; CD1A; CD1C; CD1c antigen; CD1c molecule; R7; T cell surface glycoprotein CD1c; T cell surface glycoprotein CD1c precursor…

Compound Information

Name sodium arsenite
CAS sodium arsenenite

Reference List

PubMed Abstract RScore(About this table)
19665456 Liu J, Yu L, Coppin JF, Tokar EJ, Diwan BA, Waalkes MP: Fetal arsenic exposure appears to facilitate endocrine disruption by postnatal diethylstilbestrol in neonatal mouse adrenal. Chem Biol Interact. 2009 Dec 10;182(2-3):253-8. Epub 2009 Aug 7.

Pregnant CD1 mice were given drinking water containing 85 ppm arsenic as sodium arsenite or unaltered water from day 8 to day 18 of gestation and were allowed to deliver normally.
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19733843 Torres-Avila M, Leal-Galicia P, Sanchez-Pena LC, Del Razo LM, Gonsebatt ME: Arsenite induces aquaglyceroporin 9 expression in murine livers. Environ Res. 2009 Sep 4.

CD1 male mice were treated with different concentrations (0, 2.5, 5 or 10mg/kg/day) of sodium arsenite during 1, 3 or 9 days.
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8658531 Tabocova S, Hunter ES 3rd, Gladen BC: Developmental toxicity of inorganic arsenic in whole embryo: culture oxidation state, dose, time, and gestational age dependence. Toxicol Appl Pharmacol. 1996 Jun;138(2):298-307.

ICR and CD1 mouse embryos were prepared for whole embryo culture and exposed to concentrations of trivalent (1, 2, 5, 7.5, 10, 20, and 30 microM of sodium arsenite) and pentavalent arsenic (5, 10, 20, 50, and 100 microM of sodium arsenate) at different developmental stages (3, 4-6, 8-10, or 20-23 pairs of somites) and for different exposure periods (1, 4, 6, or 24 hr).
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11706373 Belles M, Albina ML, Sanchez DJ, Corbella J, Domingo JL: Interactions in developmental toxicology: effects of concurrent exposure to lead, organic mercury, and arsenic in pregnant mice. Arch Environ Contam Toxicol. 2002 Jan;42(1):93-8.

The development toxicity of lead nitrate (25 mg/kg, SC), methylmercury chloride (12.5 mg/kg, PO), and sodium arsenite (6 mg/kg, SC) was assessed in CD1 mice following administration on gestation day 10 of these chemicals separately or in their binary and ternary combinations.
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17306315 Waalkes MP, Liu J, Diwan BA: Transplacental arsenic carcinogenesis in mice. Toxicol Appl Pharmacol. 2007 Aug 1;222(3):271-80. Epub 2007 Jan 12.

Male CD1 mice treated with arsenic in utero develop tumors of the liver and adrenal and renal hyperplasia while females develop tumors of urogenital system, ovary, uterus and adrenal and hyperplasia of the oviduct.
In these studies pregnant mice were treated with drinking water containing sodium arsenite at up to 85 ppm arsenic from days 8 to 18 of gestation, and the offspring were observed for up to 2 years.
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