| Name | bcl 2 |
|---|---|
| Synonyms | Apoptosis regulator Bcl 2; B cell CLL/lymphoma 2; B cell lymphoma protein 2 alpha; B cell lymphoma protein 2 alpha isoform; BCL2; Bcl 2; B cell CLL/lymphoma 2s; B cell lymphoma protein 2 alphas… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18465250 | Cai B, Xia Z: p38 MAP kinase mediates arsenite-induced apoptosis through FOXO3a activation and induction of Bim transcription. Apoptosis. 2008 Jun;13(6):803-10. Sodium arsenite induces apoptosis in PC12 cells by activating the stress-activated p38 MAP kinase and the pro-apoptotic Bcl-2 family protein Bim (EL). |
31(0,1,1,1) | Details |
| 9688289 | Ma DC, Sun YH, Chang KZ, Ma XF, Huang SL, Bai YH, Kang J, Liu YG, Chu JJ: Selective induction of apoptosis of NB4 cells from G2+M phase by sodium arsenite at lower doses. Eur J Haematol. 1998 Jul;61(1):27-35. With increment of the cells blocked in G2 phase, -specifically labeling cells in G2+M phase increased without concomitant increment of -labeling cells in other two phases of cell cycle; 2) at high doses, extensive apoptosis was induced in NB4 cells from all phases of cell cycle without cell cycle preference and cell cycle blockade; 3) sodium arsenite-induced apoptosis of NB4 cells occurred in the presence of bcl-2 expression as the unapoptotic cells; 4) sodium arsenite with As3+ induced apoptosis of NB4 cells more strongly than arsenate with As5+ did although both of them affected NB4 cells in the same pattern. |
31(0,1,1,1) | Details |
| 16818494 | Cai B, Chang SH, Becker EB, Bonni A, Xia Z: p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65. J Biol Chem. 2006 Sep 1;281(35):25215-22. Epub 2006 Jul 3. Potential targets for these kinases include members of the Bcl-2 family proteins, which mediate apoptosis generated through the mitochondria-initiated, intrinsic cell death pathway. Here we report evidence that sodium arsenite-induced apoptosis in PC12 cells may be due to direct phosphorylation of Bim (EL) at Ser-65 by p38. |
4(0,0,0,4) | Details |
| 15377153 | Lee CH, Yu CL, Liao WT, Kao YH, Chai CY, Chen GS, Yu HS: Effects and interactions of low doses of arsenic and UVB on keratinocyte apoptosis. Chem Res Toxicol. 2004 Sep;17(9):1199-205. Cultured human keratinocytes were treated with sodium arsenite (1 microM) and/or UVB (50 mJ/cm (2)) irradiation in different combinations: (i) arsenic alone, (ii) UVB alone, (iii) arsenic followed by UVB (As-UVB), and (iv) UVB followed by arsenic (UVB-As) treatments. UVB irradiation significantly decreased Bcl-2 expression. |
3(0,0,0,3) | Details |
| 12690470 | Zhou H, Kato A, Yasuda H, Odamaki M, Itoh H, Hishida A: The induction of heat shock protein-72 attenuates cisplatin-induced acute renal failure in rats. Pflugers Arch. 2003 Apr;446(1):116-24. Epub 2003 Feb 15. Uranyl (UA) or sodium arsenite (SA) were administered i.v. 14 days or 1 day respectively before CDDP injection to induce HSPs. The expression of HSP72, B-cell lymphoma gene product-2 (Bcl-2) and Bax were evaluated by Western blot analysis. |
3(0,0,0,3) | Details |
| 12730627 | Muscarella DE, O'Brien KA, Lemley AT, Bloom SE: Reversal of Bcl-2-mediated resistance of the EW36 human B-cell lymphoma cell line to arsenite- and pesticide-induced apoptosis by PK11195, a ligand of the mitochondrial benzodiazepine receptor. Toxicol Sci. 2003 Jul;74(1):66-73. Epub 2003 May 2. Furthermore, using sodium arsenite, we examined the role of the c-Jun N-terminal kinase (JNK) pathway and protein synthesis in apoptosis induction in EW36. |
3(0,0,0,3) | Details |
| 9403530 | Gordon SA, Hoffman RA, Simmons RL, Ford HR: Induction of heat shock protein 70 protects thymocytes against radiation-induced apoptosis. Arch Surg. 1997 Dec;132(12):1277-82. Fragmentation of DNA was quantitated, and p53, bax, and bcl-2 expression was analyzed at various times by the Western blot method. Induction of HSP 70 in T-cell clones with sodium arsenite had a similar protective effect against radiation-induced apoptosis. |
2(0,0,0,2) | Details |
| 16966277 | Glienke W, Chow KU, Bauer N, Bergmann L: Down-regulation of wt1 expression in leukemia cell lines as part of apoptotic effect in arsenic treatment using two compounds. Leuk Lymphoma. 2006 Aug;47(8):1629-38. HL-60 and K562 were treated with arsenic trioxide (As2O3) and sodium arsenite (NaAsO2) at concentrations between 0 - 10 microM for up to 48 h. Low concentrations of 0.1 microM arsenic induced expression of the anti-apoptotic bcl-2 gene in both cell lines HL-60 and K562. |
2(0,0,0,2) | Details |
| 10964950 | Namgung U, Xia Z: Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase. J Neurosci. 2000 Sep 1;20(17):6442-51. Moreover, the caspase inhibitor zVAD-fluoromethylketone as well as expression of bcl-2 or bcl-xL inhibited cortical neuron apoptosis induced by arsenite or by constitutive activation of JNK or p38. Here we investigated the role of JNK and p38 in cortical neuron apoptosis caused by sodium arsenite treatment. |
2(0,0,0,2) | Details |
| 19082730 | Chowdhury R, Chowdhury S, Roychoudhury P, Mandal C, Chaudhuri K: Arsenic induced apoptosis in malignant melanoma cells is enhanced by through ROS generation, p38 signaling and p53 activation. Apoptosis. 2009 Jan;14(1):108-23. MATERIALS METHODS AND RESULTS: synergized NaAsO (2) to significantly increase ROS generation and facilitate the major apoptotic signaling events: alteration of mitochondrial membrane potential, cytochrome c release and anti-apoptotic protein Bcl-2 down-regulation and subsequent activation of caspase-9 and caspase-3 followed by poly-ADP- polymerase-1 cleavage. |
1(0,0,0,1) | Details |
| 17645694 | Lin AM, Fang SF, Chao PL, Yang CH: attenuates arsenite-induced apoptosis in rat brain: involvement of mitochondrial and endoplasmic reticulum pathways and aggregation of alpha-synuclein. J Pineal Res. 2007 Sep;43(2):163-71. In the present study, the protective effect of on sodium arsenite (arsenite)-induced apoptosis was investigated. In the mitochondrial pathway, systemic inhibited arsenite-induced elevations in Bcl-2 and cytosolic cytochrome c as well as arsenite-induced reductions in procaspase-3 levels and elevations in active caspase-3 levels in the infused SN. |
1(0,0,0,1) | Details |
| 19429265 | Das J, Ghosh J, Manna P, Sinha M, Sil PC: protects rat testes against NaAsO (2)-induced oxidative stress and apoptosis via mitochondrial dependent and independent pathways. Toxicol Lett. 2009 Jun 22;187(3):201-10. Epub 2009 Mar 14. In this study, we report that As administration (in the form of NaAsO (2) at a dose of 10mg/kg body weight for 2 days, orally) induces apoptosis in testicular tissue of the experimental rats by the activation of caspase-3 and reciprocal regulation of Bcl-2/Bad with the concomitant reduction of mitochondrial membrane potential and increased level of cytosolic cytochrome C. |
2(0,0,0,2) | Details |
| 12464623 | Muscarella DE, Bloom SE: Cross-linking of surface IgM in the Burkitt's lymphoma cell line ST486 provides protection against arsenite- and stress-induced apoptosis that is mediated by ERK and phosphoinositide 3-kinase signaling pathways. J Biol Chem. 2003 Feb 7;278(6):4358-67. Epub 2002 Dec 2. Our study also provides evidence for p90 (S6) ribosomal kinase as a point of convergence between the two signaling pathways resulting in the phosphorylation of the pro-apoptotic Bcl-2 family member Bad at serine 112. Moreover, this cell line is highly sensitive to the induction of apoptosis by many chemicals, including sodium arsenite, a significant environmental contaminant with immunotoxic activity. |
1(0,0,0,1) | Details |
| 19672740 | Roy A, Manna P, Sil PC: Prophylactic role of on arsenic mediated oxidative renal dysfunction via MAPKs/ NF-kappaB and mitochondria dependent pathways. Free Radic Res. 2009 Oct;43(10):995-1007. Epub 2009 Aug 11. Investigating the responsible signalling cascades, it was found that NaAsO (2) administration activates mitogen-activated protein kinases (MAPKs) and NF-kappaB in oxidative stress mediated renal dysfunction and induced apoptotic cell death by the reciprocal regulation of Bcl-2/Bad in association with reducing mitochondrial membrane potential and increased cytosolic cytochrome C as well. |
1(0,0,0,1) | Details |
| 12075113 | Muscarella DE, Bloom SE: Differential activation of the c-Jun N-terminal kinase pathway in arsenite-induced apoptosis and sensitization of chemically resistant compared to susceptible B-lymphoma cell lines. Toxicol Sci. 2002 Jul;68(1):82-92. Therefore, we investigated the involvement of key mitogen-activated protein kinase pathways and apoptosis induction by sodium arsenite in a model system of chemically resistant and susceptible B-lymphoma cell lines. Importantly, we found that EW36 cells, which overexpress the Bcl-2 protein, can be substantially sensitized to arsenite-induced apoptosis by prior exposure to nonlethal hyperthermia. |
1(0,0,0,1) | Details |
| 11035063 | Hossain K, Akhand AA, Kato M, Du J, Takeda K, Wu J, Takeuchi K, Liu W, Suzuki H, Nakashima I: Arsenite induces apoptosis of murine T lymphocytes through membrane raft-linked signaling for activation of c-Jun amino-terminal kinase. J Immunol. 2000 Oct 15;165(8):4290-7. NaAsO (2) induced apoptosis through fragmentation of DNA, activation of caspase, and reciprocal regulation of Bcl-2/Bax with the concomitant reduction of membrane potential. |
1(0,0,0,1) | Details |
| 18715270 | Lin AM, Feng SF, Chao PL, Yang CH: inhibits arsenite-induced peripheral neurotoxicity. J Pineal Res. 2009 Jan;46(1):64-70. Epub 2008 Aug 18. In this study, the effect of on sodium arsenite (arsenite)-induced peripheral neurotoxicity was investigated using dorsal root ganglion (DRG) explants. In the mitochondrial pathway, arsenite-induced increases in Bcl-2 levels and cytosolic cytochrome c were reduced by |
1(0,0,0,1) | Details |