Protein Information

Name PEPCK
Synonyms Full length cDNA clone CS0DC022YA24 of Neuroblastoma of Homo sapiens; PEP carboxykinase; Phosphoenolpyruvate carboxylase; Mitochondrial phosphoenolpyruvate carboxykinase 2; PCK 2; PCK2; PCK2 protein; PEPCK…

Compound Information

Name sodium arsenite
CAS sodium arsenenite

Reference List

PubMed Abstract RScore(About this table)
18505831 Chanda D, Kim SJ, Lee IK, Shong M, Choi HS: Sodium arsenite induces orphan nuclear receptor SHP gene expression via AMP-activated protein kinase to inhibit gluconeogenic enzyme gene expression. Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E368-79. Epub 2008 May 27.

Sodium arsenite inhibited the promoter activity of PEPCK and G6Pase, and this repression was abolished by small interfering (si) RNA SHP treatments.
169(2,2,3,4) Details
9712902 Cheong J, Coligan JE, Shuman JD: Activating transcription factor-2 regulates phosphoenolpyruvate carboxykinase transcription through a stress-inducible mitogen-activated protein kinase pathway. J Biol Chem. 1998 Aug 28;273(35):22714-8.

In this regard, we show that treatment with sodium arsenite, a known activator of p38 MAP kinases, also stimulates expression from the PEPCK promoter.
81(1,1,1,1) Details
8971075 Sutherland C, Tebbey PW, Granner DK: Oxidative and chemical stress mimic insulin by selectively inhibiting the expression of phosphoenolpyruvate carboxykinase in hepatoma cells. Diabetes. 1997 Jan;46(1):17-22.


Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the rate-limiting step in hepatic gluconeogenesis.
4(0,0,0,4) Details